scholarly journals Effects of Fill Volume and Humidification on Aerosol Delivery During Single-Limb Noninvasive Ventilation

2018 ◽  
Vol 63 (11) ◽  
pp. 1370-1378 ◽  
Author(s):  
Haitham Saeed ◽  
Marwa Mohsen ◽  
Abeer Salah Eldin ◽  
Ahmed A Elberry ◽  
Raghda RS Hussein ◽  
...  
Keyword(s):  
Noninvasive Ventilation ◽  
Aerosol Delivery ◽  
Fill Volume

Fill volume, humidification and heat effects on aerosol delivery and fugitive emissions during noninvasive ventilation

2017 ◽  
Vol 39 ◽  
pp. 372-378 ◽  
Author(s):  
Haitham Saeed ◽  
Marwa Mohsen ◽  
James B. Fink ◽  
Patricia Dailey ◽  
Abeer Salah Eldin ◽  
...  
Keyword(s):  
Noninvasive Ventilation ◽  
Aerosol Delivery ◽  
Fugitive Emissions ◽  
Heat Effects ◽  
Fill Volume

scholarly journals Aerosol delivery via noninvasive ventilation: role of models and bioanalysis

2021 ◽  
Vol 9 (7) ◽  
pp. 589-589
Author(s):  
Haitham Saeed ◽  
Hadeer S. Harb ◽  
Yasmin M. Madney ◽  
Mohamed E. A. Abdelrahim
Keyword(s):  
Noninvasive Ventilation ◽  
Aerosol Delivery

scholarly journals Impact of Gas Flow and Humidity on Trans-Nasal Aerosol Deposition via Nasal Cannula in Adults: A Randomized Cross-Over Study

Pharmaceutics ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 320 ◽  
Author(s):  
Luciana Alcoforado ◽  
Arzu Ari ◽  
Jacqueline Barcelar ◽  
Simone Brandão ◽  
James Fink ◽  
...  
Keyword(s):  
Gas Flow ◽  
Healthy Adults ◽  
Nasal Cannula ◽  
Lung Deposition ◽  
Gas Flows ◽  
Aerosol Delivery ◽  
Upper Airways ◽  
Fill Volume ◽  
Heated Humidification ◽  
The Impact

Background: Trans-nasal pulmonary aerosol delivery using high flow nasal cannula (HFNC) devices is described with the administration of high gas flows exceeding patient inspiratory flow (HF) and with lower flows (LF). The aim of this pilot clinical trial was to compare deposition and distribution of radiolabeled aerosol via nasal cannula in healthy adults across three rates of gas flow delivered with active heated humidification, and to further identify the impact of aerosol administration without heated humidity. Methods: Twenty-three (23) healthy adults (16F) were randomized to receive aerosol with active heated humidification or unheated oxygen at gas flows of 10 L/min (n = 8), 30 L/min (n = 7), or 50 L/min (n = 8). Diethylenetriaminepentaacetic acid labeled with 1 millicurie (37 MBq) of Technetium-99m (DTPA-Tc99m) was mixed with NaCl to a fill volume of 1 mL, and administered via mesh nebulizer placed at the inlet of the humidifier. Radioactivity counts were performed using a gamma camera and the regions of interest (ROIs) were delimited with counts from the lungs, upper airways, stomach, nebulizer, circuit, and expiratory filter. A mass balance was calculated and each compartment was expressed as a percentage of the total. Results: Lung deposition (mean ± SD) with heated humidified gas was greater at 10 L/min than 30 L/min or 50 L/min (17.2 ± 6.8%, 5.71 ± 2.04%, and 3.46 ± 1.24%, respectively; p = 0.0001). Using unheated carrier gas, a lung dose of aerosol was similar to the active heated humidification condition at 10 L/min, but greater at 30 and 50 L/min (p = 0.011). Administered gas flow and lung deposition were negatively correlated (r = −0.880, p < 0.001). Conclusions: Both flow and active heated humidity inversely impact aerosol delivery through HFNC. Nevertheless, aerosol administration across the range of commonly used flows can provide measurable levels of lung deposition in healthy adult subjects (NCT 02519465).

scholarly journals Face Mask Leak Determines Aerosol Delivery in Noninvasive Ventilation

2020 ◽  
Vol 66 (1) ◽  
pp. 95-103
Author(s):  
Alexandra Haw ◽  
Michael McPeck ◽  
Ann D Cuccia ◽  
Gerald C Smaldone
Keyword(s):  
Noninvasive Ventilation ◽  
Face Mask ◽  
Aerosol Delivery

Noninvasive Ventilation Overused Beyond COPD

2012 ◽  
Vol 5 (8) ◽  
pp. 18
Author(s):  
M. ALEXANDER OTTO
Keyword(s):  
Noninvasive Ventilation
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