scholarly journals Humidity and Inspired Oxygen Concentration During High-Flow Nasal Cannula Therapy in Neonatal and Infant Lung Models

2017 ◽  
Vol 62 (5) ◽  
pp. 532-537 ◽  
Author(s):  
Yusuke Chikata ◽  
Saki Ohnishi ◽  
Masaji Nishimura
Complexity ◽  
2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Jingen Xia ◽  
Jiaqi Chang ◽  
Jixiang Liang ◽  
Yixuan Wang ◽  
Na Wang

The mechanical ventilation of human body is a complex human-computer interaction process. High flow nasal cannula oxygen therapy (HFNC) is a new type of ventilation, which is often measured by lung pressure, respiratory work, and other parameters. The purpose of this paper is to analyse the pressure, flow, and strain rate of upper respiratory tract with different flow and oxygen concentration by using finite element simulation, to guide professionals to adjust the appropriate flow and oxygen concentration parameters of HFNC machine. This paper studies the complex human-computer interaction environment of human respiratory tract and ventilation airflow. The 3D model of respiratory tract established by the conversion of image scanning data was taken as the research object. The flow state of the gases in the respiratory tract was judged by Reynolds equation. After that, RNG K-ε model was applied to the research object, and the simulation diagram of airway pressure, flow rate, strain rate, and trace diagram of flowing particles were obtained under the finite element method. The results explain some clinical phenomena in HFNC and guide people to make better use of mathematical tools to study human-computer complex environment.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ga Eun Kim ◽  
Sun Ha Choi ◽  
Mireu Park ◽  
Jae Hwa Jung ◽  
Myeongjee Lee ◽  
...  

AbstractThe high-flow nasal cannula (HFNC) is a useful treatment modality for acute hypoxemic respiratory failure (AHRF) in children. We compared the ability of the oxygen saturation to fraction of inspired oxygen ratio (S/F) and arterial oxygen partial pressure to fraction of inspired oxygen ratio (P/F) to predict HFNC outcomes in children with AHRF. This study included children treated with HFNC due to AHRF from April 2013 to March 2019 at the Severance Children’s Hospital. HFNC failure was defined as the need for mechanical ventilation. Trends of S/F and P/F during HFNC were analyzed. To predict HFNC outcomes, a nomogram was constructed based on predictive factors. A total of 139 patients with arterial blood gas data were included in the S/F and P/F analyses. S/F < 230 at initiation showed high prediction accuracy for HFNC failure (area under the receiver operating characteristic curve: 0.751). Univariate analyses identified S/F < 230 at HFNC initiation and < 200 at 2 h (odds ratio [OR] 12.83, 95% CI 5.06–35.84), and hemato-oncologic disease (OR 3.79, 95% CI 1.12–12.78) as significant predictive factors of HFNC failure. The constructed nomogram had a highly predictive performance, with a concordance index of 0.765 and 0.831 for the exploratory and validation groups, respectively. S/F may be used as a predictor of HFNC outcomes. Our nomogram with S/F for HFNC failure within 2 h may prevent delayed intubation in children with AHRF.


2016 ◽  
Vol 44 (6) ◽  
pp. 1200-1211 ◽  
Author(s):  
Jian Zhang ◽  
Ling Lin ◽  
Konghan Pan ◽  
Jiancang Zhou ◽  
Xiaoyin Huang

High-flow nasal cannula (HFNC) oxygen therapy has several physiological advantages over traditional oxygen therapy devices, including decreased nasopharyngeal resistance, washing out of the nasopharyngeal dead space, generation of positive pressure in the pharynx, increasing alveolar recruitment in the lungs, humidification of the airways, increased fraction of inspired oxygen and improved mucociliary clearance. Recently, the use of HFNC in treating adult critical illness patients has significantly increased, and it is now being used in many patients with a range of different disease conditions. However, there are no established guidelines to direct the safe and effective use of HFNC for these patients. This review article summarizes the available published literature on the positive physiological effects, mechanisms of action, and the clinical applications of HFNC, compared with traditional oxygen therapy devices. The available literature suggests that HFNC oxygen therapy is an effective modality for the early treatment of critically adult patients.


2021 ◽  
Vol 16 (4) ◽  
pp. 338-343
Author(s):  
Joonhee Gook ◽  
Ji-Hye Kwon ◽  
Keoungah Kim ◽  
Jung Won Choi ◽  
Ik Soo Chung ◽  
...  

Background: Awake craniotomy is a well-tolerated procedure for the resection of brain tumors residing within or close to the eloquent cortical areas. Monitored anesthesia care (MAC) is a dominant anesthetic approach for awake craniotomy; however, it is associated with inherent challenges such as desaturation and hypercapnia, which may lead to various complications. The prevention of respiratory insufficiency is important for successful awake craniotomy. As measures to avoid respiratory depression, the use of high-flow nasal cannula (HFNC) can improve patient oxygenation and monitor the oxygen reserve index (ORi) to detect hypoxia earlier. Case: We report two cases of awake craniotomy with MAC using HFNC and ORi. We adjusted the fraction of inspired oxygen of the HFNC according to the ORi level. The patient underwent successful awake craniotomy without a desaturation event or additional airway intervention. Conclusions: Combined HFNC and ORi monitoring may provide adequate oxygen reserves in patients undergoing awake craniotomy.


PEDIATRICS ◽  
2016 ◽  
Vol 137 (Supplement 3) ◽  
pp. 642A-642A
Author(s):  
Vivien Carrion ◽  
Matthew Parrish ◽  
Praveen Chandrasekharan

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