scholarly journals Utility of Red Blood Cell Acetylcholinesterase Measurement in Mechanically Ventilated Subjects After Organophosphate Poisoning

2014 ◽  
Vol 59 (9) ◽  
pp. 1360-1368 ◽  
Author(s):  
J. Moon ◽  
B. Chun
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Organophosphate Poisoning ◽  
Mechanically Ventilated

scholarly journals Intestinal and sublingual microcirculation are more severely compromised in hemodilution than in hemorrhage

2016 ◽  
Vol 120 (10) ◽  
pp. 1132-1140 ◽  
Author(s):  
Gonzalo Ferrara ◽  
Vanina Siham Kanoore Edul ◽  
Enrique Martins ◽  
Héctor Saúl Canales ◽  
Carlos Canullán ◽  
...  
Keyword(s):  
Cardiac Output ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Alternative Explanation ◽  
Vascular Density ◽  
Mechanically Ventilated ◽  
Sublingual Microcirculation ◽  
Intestinal Microcirculation ◽  
Fast Red ◽  
Last Stage

The alterations in O2 extraction in hemodilution have been linked to fast red blood cell (RBC) velocity, which might affect the complete release of O2 from Hb. Fast RBC velocity might also explain the normal mucosal-arterial Pco2 (ΔPco2). Yet sublingual and intestinal microcirculation have not been completely characterized in extreme hemodilution. Our hypothesis was that the unchanged ΔPco2 in hemodilution depends on the preservation of villi microcirculation. For this purpose, pentobarbital-anesthetized and mechanically ventilated sheep were submitted to stepwise hemodilution ( n = 8), hemorrhage ( n = 8), or no intervention (sham, n = 8). In both hypoxic groups, equivalent reductions in O2 consumption (V̇o2) were targeted. Microcirculation was assessed by videomicroscopy, intestinal ΔPco2 by air tonometry, and V̇o2 by expired gases analysis. Although cardiac output and superior mesenteric flow increased in hemodilution, from the very first step (Hb = 5.0 g/dl), villi functional vascular density and RBC velocity decreased (21.7 ± 0.9 vs. 15.9 ± 1.0 mm/mm2 and 1,033 ± 75 vs. 850 ± 79 μm/s, P < 0.01). In the last stage (Hb = 1.2 g/dl), these variables were lower in hemodiution than in hemorrhage (11.1 ± 0.5 vs. 15.4 ± 0.9 mm/mm2 and 544 ± 26 vs. 686 ± 70 μm/s, P < 0.01), and were associated with lower intestinal fractional O2 extraction (0.61 ± 0.04 vs. 0.79 ± 0.02, P < 0.01) but preserved ΔPco2 (5 ± 2 vs. 25 ± 4 mmHg, P < 0.01). Therefore, alterations in O2 extraction in hemodilution seemed related to microvascular shunting, not to fast RBC velocity. The severe microvascular abnormalities suggest that normal ΔPco2 was not dependent on CO2 washout by the villi microcirculation. Increased perfusion in deeper intestinal layers might be an alternative explanation.

The Acute Effect of Packed Red Blood Cell Transfusion in Mechanically Ventilated Children after the Norwood Operation

2021 ◽  
Author(s):  
Riddhi D. Patel ◽  
Julia Weld ◽  
Saul Flores ◽  
Enrique G. Villarreal ◽  
Juan S. Farias ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Acute Effect ◽  
Red Blood Cell Transfusion ◽  
Norwood Operation ◽  
Mechanically Ventilated

scholarly journals Organophosphate poisoning from inappropriate topical use of malathion pesticide: A case report

2022 ◽  
pp. 201010582110685
Author(s):  
Joe Jia-Liang Chua ◽  
Kaibin K. Kuan
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Reference Range ◽  
General Ward ◽  
Serum Cholinesterase ◽  
Organophosphate Poisoning ◽  
Past Medical History ◽  
The Past ◽  
Neurologic Sequelae

A 43-year-old male with no past medical history presented to our emergency department with vomiting, diarrhea, and abdominal pain of 3 h’ duration. Upon further questioning, he revealed that he had been applying malathion pesticide over his body for the past 3 days for self-diagnosed scabies. He was otherwise afebrile and hemodynamically stable, and the physical examination was unremarkable. The patient was diagnosed with organophosphate poisoning and treated symptomatically due to the lack of worrying cardiorespiratory or neurologic sequelae. He was subsequently admitted to the general ward, where his symptoms abated within 4 h. Serum and red blood cell cholinesterase tests sent on admission returned on day three and were significantly decreased (serum cholinesterase 2131 U/L, reference range 4700–12000 U/L; red blood cell cholinesterase 3365 U/L, reference range 7700–14600 U/L). He was discharged home well and stable on day 5 of admission, with outpatient psychiatric follow-up for likely delusional parasitosis.

Oxygen content and prediction of packed red blood cell transfusion in mechanically ventilated neonate

2017 ◽  
Vol 6 (4) ◽  
pp. 236
Author(s):  
MohammadKamrul Hassan Shabuj ◽  
SadekaChoudhury Moni ◽  
Ismat Jahan ◽  
SanjoyKumer Dey ◽  
Md.Abdul Mannan ◽  
...  
Keyword(s):  
Blood Cell ◽  
Oxygen Content ◽  
Red Blood Cell ◽  
Red Blood Cell Transfusion ◽  
Mechanically Ventilated
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