scholarly journals Scintigraphic Assessment of Radio-Aerosol Pulmonary Deposition With the Acapella Positive Expiratory Pressure Device and Various Nebulizer Configurations

2013 ◽  
Vol 59 (3) ◽  
pp. 328-333 ◽  
Author(s):  
F. O. S. Mesquita ◽  
V. C. Galindo-Filho ◽  
J. L. F. Neto ◽  
A. M. Galvao ◽  
S. C. S. Brandao ◽  
...  
Keyword(s):  
Pulmonary Deposition ◽  
Scintigraphic Assessment ◽  
Positive Expiratory Pressure

scholarly journals A short-term evaluation of a prototype disposable Oscillating Positive Expiratory Pressure (OPEP) device in a cohort of children with cystic fibrosis

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Kevin J. O’Sullivan ◽  
Valerie Power ◽  
Barry Linnane ◽  
Deirdre McGrath ◽  
Magdalena Mulligan ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Lung Function ◽  
Clinical Investigation ◽  
Mean Difference ◽  
Short Term ◽  
Intervention Participant ◽  
Post Intervention ◽  
Convenience Sample ◽  
Disposable Device ◽  
Positive Expiratory Pressure

Abstract Background Oscillating Positive Expiratory Pressure (OPEP) devices are important adjuncts to airway clearance therapy in patients with cystic fibrosis (CF). Current devices are typically reusable and require daily, or often more frequent, cleaning to prevent risk of infection by acting as reservoirs of potentially pathogenic organisms. In response, a daily disposable OPEP device, the UL-OPEP, was developed to mitigate the risk of contamination and eliminate the burdensome need for cleaning devices. Methods A convenience sample of 36 participants, all current OPEP device users, was recruited from a paediatric CF service. For one month, participants replaced their current OPEP device with a novel daily disposable device. Assessment included pre- and post-intervention lung function by spirometry, as well as Lung Clearance Index. Quality of life was assessed using the Cystic Fibrosis Questionnaire – Revised, while user experience was evaluated with a post-study survey. Results 31 participants completed the study: 18 males; median age 10 years, range 4–16 years. Lung function (mean difference ± SD, %FEV1 = 1.69 ± 11.93; %FVC = 0.58 ± 10.04; FEV1: FVC = 0.01 ± 0.09), LCI (mean difference ± SD, 0.08 ± 1.13), six-minute walk test, and CFQ-R were unchanged post-intervention. Participant-reported experiences of the device were predominantly positive. Conclusions The disposable OPEP device maintained patients’ lung function during short term use (≤ 1 month), and was the subject of positive feedback regarding functionality while reducing the risk of airway contamination associated with ineffective cleaning. Registration The study was approved as a Clinical Investigation by the Irish Health Products Regulatory Authority (CRN-2209025-CI0085).

scholarly journals Comparison of pulmonary deposition of nebulized 99m technetium‐diethylenetriamine‐pentaacetic acid through 3 inhalation devices in healthy dogs

2021 ◽  
Vol 35 (2) ◽  
pp. 1080-1087
Author(s):  
Alejandra Carranza Valencia ◽  
Reinhard Hirt ◽  
Doris Kampner ◽  
Andreas Hiebl ◽  
Alexander Tichy ◽  
...  
Keyword(s):  
Pulmonary Deposition ◽  
Inhalation Devices ◽  
Healthy Dogs ◽  
Diethylenetriamine Pentaacetic Acid

Treatment of Bronchial Asthma with Terbutaline Inhaled by Conespacer Combined with Positive Expiratory Pressure Mask

CHEST Journal ◽  
1991 ◽  
Vol 100 (2) ◽  
pp. 317-321 ◽  
Author(s):  
Erika Frischknecht-Christensen ◽  
Ole Nørregaard ◽  
Ronald Dahl
Keyword(s):  
Bronchial Asthma ◽  
Positive Expiratory Pressure

Stress fractures after surgery for osteosarcoma: scintigraphic assessment.

Radiology ◽  
1987 ◽  
Vol 163 (1) ◽  
pp. 157-162 ◽  
Author(s):  
T Ben Ami ◽  
S T Treves ◽  
S Tumeh ◽  
J Cox-Bryan ◽  
C McCarthy
Keyword(s):  
Stress Fractures ◽  
Scintigraphic Assessment

Oral [111In]DTPA scintigraphic assessment of colonic transit in constipated subjects

1993 ◽  
Vol 38 (6) ◽  
pp. 1032-1039 ◽  
Author(s):  
J. P. Roberts ◽  
M. S. Newell ◽  
J. J. Deeks ◽  
D. W. Waldron ◽  
N. W. Garvie ◽  
...  
Keyword(s):  
Colonic Transit ◽  
Scintigraphic Assessment

Pulmonary deposition of aerosolised pentamidine using a new nebuliser: efficiency measurements in vitro and in vivo

1994 ◽  
Vol 21 (5) ◽  
Author(s):  
PierPaolo Ferretti ◽  
Annibale Versari ◽  
SergioIgnazio Gaf� ◽  
MarieHelene Becquemin ◽  
Enrico Barchi ◽  
...  
Keyword(s):  
Pulmonary Deposition ◽  
Aerosolised Pentamidine

Positive Expiratory Pressure: A Potential Therapy to Mitigate Acute Bronchoconstriction in the Asthma of Obesity

2021 ◽  
Author(s):  
Swati a. Bhatawadekar ◽  
Anne E. Dixon ◽  
Ubong Peters ◽  
Nirav Daphtary ◽  
Kevin Hodgdon ◽  
...  
Keyword(s):  
Airway Resistance ◽  
Late Onset ◽  
Rescue Therapy ◽  
Pharmacologic Therapy ◽  
Airway Closure ◽  
Airway Narrowing ◽  
Asthma Patients ◽  
Peripheral Airway ◽  
Central Airway ◽  
Positive Expiratory Pressure

Late-onset non-allergic (LONA) asthma in obesity is characterized by increased peripheral airway closure secondary to abnormally collapsible airways. We hypothesized that positive expiratory pressure (PEP) would mitigate the tendency to airway closure during bronchoconstriction, potentially serving as rescue therapy for LONA asthma of obesity. The PC20 dose of methacholine was determined in 18 obese participants with LONA asthma. At each of 4 subsequent visits, we used oscillometry to measure input respiratory impedance (Zrs) over 8 minutes; participants received their PC20 concentration of methacholine aerosol during the first 4.5 minutes. PEP combinations of either 0 or 10 cmH2O either during and/or after the methacholine delivery were applied, randomized between visits. Parameters characterizing respiratory system mechanics were extracted from the Zrs spectra. In 18 LONA asthma patients (14 females, BMI: 39.6±3.4 kg/m2), 10 cmH2O PEP during methacholine reduced elevations in the central airway resistance, peripheral airway resistance and elastance, and breathing frequency was also reduced. During the 3.5 min following methacholine delivery, PEP of 10 cmH2O reduced Ax and peripheral elastance compared to no PEP. PEP mitigates the onset of airway narrowing brought on by methacholine challenge, and airway closure once it is established. PEP thus might serve as a non-pharmacologic therapy to manage acute airway narrowing for obese LONA asthma.

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