scholarly journals Endobronchial Metastasis of a Primary Transitional-Cell and Signet-Ring Cell Carcinoma of the Urinary Bladder

2011 ◽  
Vol 56 (7) ◽  
pp. 1033-1036 ◽  
Author(s):  
N. Cekmen ◽  
S. Aciksoz ◽  
H. Serdaroglu ◽  
O. Erdemli ◽  
T. Inan
1985 ◽  
Vol 11 (3) ◽  
pp. 212-214 ◽  
Author(s):  
M. Ponz ◽  
J. Luzuriaga ◽  
J.E. Robles ◽  
F. Guillén ◽  
J.M. Urmeneta ◽  
...  

2021 ◽  
Vol 156 (Supplement_1) ◽  
pp. S44-S44
Author(s):  
B W Taylor ◽  
K Hummel ◽  
Y Xu

Abstract Introduction/Objective Endobronchial metastasis (EBM) is uncommon, with a reported prevalence of 2% in cases of non-lung primary malignancies. The most frequently observed carcinomas in EBM are from breast, colon, and renal origins. We present a rare case of endobronchial metastasis from a primary tumor of the appendix without lung masses by computed tomography (CT). Methods/Case Report An 83-year-old woman with signet-ring cell carcinoma of the appendix underwent right hemicolectomy and chemotherapy. Two years later, she returned with intractable nausea and vomiting, and respiratory distress. CT of the chest demonstrated diffuse bilateral pulmonary opacities without lung masses. CT of the abdomen showed peritoneal carcinomatosis. Cytology of ascitic fluid displayed metastasis of the patient’s known appendiceal tumor. Bronchoscopy found significant friable debris appearing to be tumor tissue and occluding multiple bronchioles in the right lung. A bronchoalveolar lavage (BAL) specimen from the right lung was sent for liquid-based cytology, which revealed a few atypical cells with eccentric nuclei and intracytoplasmic vacuoles, abundant macrophages, degenerated mixed inflammatory cells, and scattered bronchial epithelial cells. Cell block demonstrated signet-ring cells mimicking macrophages and infiltrating into small fragments of bronchiolar wall. The signet-ring cells were morphologically similar to those found in the ascitic fluid and the patient’s primary tumor, and were highlighted by mucicarmine stain and immunohistochemical stains for CDX-2 and CK20, but not CK7. Results (if a Case Study enter NA) N/A Conclusion Collectively, the findings supported the diagnosis of endobronchial metastasis of signet-ring cell carcinoma from the lower gastrointestinal tract, i.e. the patient’s known appendiceal primary. Our case demonstrates a rare endobronchial metastasis of a primary neoplasm of the appendix, an important diagnostic consideration when evaluating respiratory distress in patients with such cancer histories. We have described the significant role of BAL cytology to uncover endobronchial metastases without lung masses by CT, and illustrated the finding of signet-ring cells mimicking macrophages in a BAL cytology specimen.


1981 ◽  
Vol 36 (6) ◽  
pp. 373-379 ◽  
Author(s):  
Atsuo Kondo ◽  
Bun-ichi Ogisu ◽  
Hideo Mitsuya

Urology ◽  
1981 ◽  
Vol 17 (5) ◽  
pp. 481-483 ◽  
Author(s):  
Hiroki Yoshida ◽  
Hidenobu Iwata ◽  
Kenji Ochi ◽  
Aichi Yoshida ◽  
Ryo Fukunishi

2017 ◽  
Vol 8 (3) ◽  
pp. 443-446
Author(s):  
B. Nerli Rajendra ◽  
Nitin D. Pingale ◽  
Shridhar C. Ghagane ◽  
Ameya T. Wagh ◽  
Prakah R. Malur

2011 ◽  
Vol 29 (7_suppl) ◽  
pp. 275-275
Author(s):  
J. Wang ◽  
F. Wang ◽  
C. A. Enke

275 Background: Signet-ring cell carcinoma (SRCC) of the urinary bladder is a rare entity. Recent case series of the condition showed inconsistent results. We used a population-based data set to compare the cancer specific survival of patients with signet-ring cell carcinoma vs. transitional cell carcinoma (TCC) of the urinary bladder. Methods: Signet-ring cell carcinoma of the urinary bladder and transitional carcinoma of the urinary bladder were identified in the Surveillance, Epidemiology and End Results program (2001 to 2004). Demographic and pathological characteristics at diagnosis were compared. Differences in cancer specific survival were compared with univariate and multivariate Cox regression analysis. Results: A total of 103 SRCC cases were present in the database from 2001 to 2004. In that time 14,648 cases TCC cases were diagnosed. SRCC was more common in younger than in older patients (p <0.001); more commonly presented with high grade histology (p <0.001) and advanced stage disease (p <0.001). The 3-year cancer specific survival rate was 67.0% and 33.2% for TCC and SRCC, respectively. On multivariate analysis there was an increased mortality risk in patients with SRCC vs TCC (HR 1.42, 95% CI 1.03–1.97, p <0.001). When only high grade cases of SRCC and TCC were compared, the risk was still worse in SRCC (HR 1.430, 95% CI 1.035–1.976, 0.03). When only local stage of SRCC and TCC were compared, the risk was worse in SRCC (HR 4.294, 95% CI 1.035–17.825, 0.045). Limited to patient who underwent cystectomy only, the difference in cancer specific survival disappeared (HR 1.289, 95% CI 0.771–2.155, 0.33). Conclusions: Even after adjusting for demographic, pathological and treatment factors, cancer specific survival is significantly worse in patients with SRCC than TCC. Further research into the biology of this rare tumor is required to explain these results. No significant financial relationships to disclose.


1985 ◽  
Vol 35 (3) ◽  
pp. 675-686 ◽  
Author(s):  
Hajime Kitamura ◽  
Takayuki Sumikawa ◽  
Hiroshi Fukuoka ◽  
Masayoshi Kanisawa

1998 ◽  
Vol 37 (3) ◽  
pp. 353-357
Author(s):  
Minatsu MIYASAKA ◽  
Nobuyoshi HIRAOKA ◽  
Hirotaka ISHIMORI ◽  
Ken MARUMO ◽  
Akinori HASHIGUCHI ◽  
...  

2021 ◽  
Vol 11 ◽  
pp. e2021264
Author(s):  
Nirmalya Benerjee ◽  
Kalpesh Parmar ◽  
Kim Vaiphei

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