scholarly journals Importance of Dehydroepiandrosterone Sulfate Assessment with Special Attention for Adrenal Tumours and Arterial Hypertension

2021 ◽  
Vol 17 (1) ◽  
pp. 68-76
Author(s):  
V Matulevicius
Keyword(s):  
Arterial Hypertension ◽  
Dehydroepiandrosterone Sulfate ◽  
Adrenal Tumours

scholarly journals Higher Estradiol and Lower Dehydroepiandrosterone-Sulfate Levels Are Associated with Pulmonary Arterial Hypertension in Men

2016 ◽  
Vol 193 (10) ◽  
pp. 1168-1175 ◽  
Author(s):  
Corey E. Ventetuolo ◽  
Grayson L. Baird ◽  
R. Graham Barr ◽  
David A. Bluemke ◽  
Jason S. Fritz ◽  
...  
Keyword(s):  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Dehydroepiandrosterone Sulfate ◽  
Pulmonary Arterial

scholarly journals Lower DHEA-S levels predict disease and worse outcomes in post-menopausal women with idiopathic, connective tissue disease- and congenital heart disease-associated pulmonary arterial hypertension

2018 ◽  
Vol 51 (6) ◽  
pp. 1800467 ◽  
Author(s):  
Grayson L. Baird ◽  
Christine Archer-Chicko ◽  
R. Graham Barr ◽  
David A. Bluemke ◽  
Andrew E. Foderaro ◽  
...  
Keyword(s):  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Dehydroepiandrosterone Sulfate ◽  
Functional Class ◽  
Walking Distance ◽  
Risk Of Death ◽  
Menopausal Women ◽  
Hormonal Modulation ◽  
Pulmonary Arterial ◽  
Post Menopausal

High oestradiol (E2) and low dehydroepiandrosterone-sulfate (DHEA-S) levels are risk factors for pulmonary arterial hypertension (PAH) in men, but whether sex hormones are related to PAH in women is unknown.Post-menopausal women aged ≥55 years with PAH were matched by age and body mass index to women without cardiovascular disease. Plasma sex hormone levels were measured by immunoassay.Lower levels of DHEA-S (p<0.001) and higher levels of E2 (p=0.02) were associated with PAH. In PAH cases (n=112), lower DHEA-S levels were associated with worse haemodynamics (all p<0.01) and more right ventricular dilatation and dysfunction (both p=0.001). Lower DHEA-S levels were associated with shorter 6-min walking distance (6MWD) (p=0.01) and worse functional class (p=0.004). Each Ln(1 µg·dL−1) decrease in DHEA-S was associated with a doubling in the risk of death (hazard ratio 2.0, 95% CI 1.5–2.7; p<0.001). Higher levels of E2 were associated with shorter 6MWD (p=0.03) and worse functional class (p=0.01).High E2 and low DHEA-S levels are associated with the risk and severity of PAH in post-menopausal women. Hormonal modulation should be studied as a treatment strategy in PAH.

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