scholarly journals The Role of Thyroid Fine-Needle Aspiration Cytology in the Treatment and Follow-Up Of Thyroid Nodules in the Pediatric Population

2019 ◽  
Vol 15 (3) ◽  
pp. 333-341
Author(s):  
A Kardelen Al
2014 ◽  
Vol 122 (5) ◽  
pp. 359-367 ◽  
Author(s):  
Esther Diana Rossi ◽  
Patrizia Straccia ◽  
Maurizio Martini ◽  
Luca Revelli ◽  
Celestino Pio Lombardi ◽  
...  

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Hui-qin Guo ◽  
Huan Zhao ◽  
Zhi-hui Zhang ◽  
Yan-li Zhu ◽  
Ting Xiao ◽  
...  

Background. The molecular work-up of thyroid nodules from fine needle aspiration samples has given clinicians a new level of diagnostic information. The aim of the present study was to evaluate the utility of molecular analysis in thyroid fine needle aspiration samples from a Chinese population.Methods. Specimens were collected from thyroid nodules by fine needle aspiration. Cytology diagnosis and genes analysis were performed and correlated with histology outcome.Results. A total of 83 patients with thyroid nodules were enrolled, including 20 benign lesions and 63 papillary carcinomas. BRAF and RAS mutations and RET/PTC gene rearrangements were found in 65.1%, 0%, and 1.6% of papillary carcinomas, respectively. No gene alterations were found in benign lesions. The combination of BRAF testing and cytology improved the accuracy of cytology from 69.9% to 89.2%(P<0.05). Moreover, BRAF testing confirmed 82.4% of papillary carcinomas with suspicious cytology and identified 33.3% of papillary carcinomas with atypia cytology.Conclusions. Of the three candidate markers, BRAF testing showed diagnostic utility in fine needle aspiration. Combining BRAF testing with cytology improves the accuracy of fine needle biopsy. Those who have positive BRAF and malignant or suspicious malignant cytology can undergo thyroidectomy without a frozen section.


PLoS ONE ◽  
2015 ◽  
Vol 10 (7) ◽  
pp. e0132939 ◽  
Author(s):  
Tommaso Bizzarro ◽  
Maurizio Martini ◽  
Carla Marrocco ◽  
Donato D’Amato ◽  
Emanuela Traini ◽  
...  

2014 ◽  
Vol 80 (5) ◽  
pp. 422-427 ◽  
Author(s):  
Agnaldo José Graciano ◽  
Carlos Takahiro Chone ◽  
Carlos Augusto Fischer ◽  
Giuliano Stefanello Bublitz ◽  
Ana Jacinta de Aquino Peixoto

2010 ◽  
Vol 54 (1) ◽  
pp. 52-55 ◽  
Author(s):  
Pedro Weslley Rosário ◽  
Saulo Purisch

OBJECTIVE: To report the results of repeat fine-needle aspiration cytology (FNAC) in thyroid nodules with an initial benign cytological diagnosis that grow during follow-up and/or present suspicious ultrasonographic characteristics. SUBJECTS AND METHODS: The sample consisted of 456 patients with 895 nodules. FNAC was repeated after 12 to 18 months in the case of nodules with suspicious ultrasonographic characteristics, irrespective of growth, and when the nodules showed significant growth. RESULTS: Among the 895 nodules examined, 102 (11.4%) presented suspicious ultrasonographic characteristics. The second FNAC revealed malignancy in 18 (17.6%) nodules, including 20% (2/10) of those showing growth and 17.4% (16/92) that did not. Seventy-six (9.6%) of 793 nodules without suspicious characteristics presented growth. Only one case (1.3%) of malignancy was diagnosed by repeat FNAC. CONCLUSIONS: The study suggests ultrasonographic characteristics rather than growth as a criterion for repeat FNAC in the case of nodules with an initial benign cytological diagnosis.


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