scholarly journals Pregabalin Treatment of Peripheral Nerve Damage in a Murine Diabetic Peripheral Neuropathy Model

2018 ◽  
Vol 14 (3) ◽  
pp. 294-299
Author(s):  
J Li
Keyword(s):  
Peripheral Neuropathy ◽  
Peripheral Nerve ◽  
Diabetic Peripheral Neuropathy ◽  
Nerve Damage ◽  
Peripheral Nerve Damage

scholarly journals Role of Inflammation in the Pathogenesis of Diabetic Peripheral Neuropathy

2019 ◽  
Vol 7 (14) ◽  
pp. 2267-2270 ◽  
Author(s):  
Daniela Ristikj-Stomnaroska ◽  
Valentina Risteska-Nejashmikj ◽  
Marija Papazova
Keyword(s):  
Peripheral Neuropathy ◽  
Peripheral Nerve ◽  
Diabetic Peripheral Neuropathy ◽  
Test Group ◽  
Nerve Damage ◽  
Control Group ◽  
Average Value ◽  
Peripheral Nerve Damage ◽  
Tnf Α

BACKGROUND: Diabetic peripheral neuropathy (DPN) means the presence of symptoms and/or signs of peripheral nerve damage that occur to people with diabetes, excluding all other causes of neuropathy. Chronic hyperglycaemia leads to increased secretion of tumour necrotic factor-alpha (TNF-α), with the development of micro and macroangiopathy, damage to nerve fibres and local demyelination. AIM: To determine the role of inflammation in the peripheral nerve damage process concerning people suffering from type II diabetes mellitus. MATERIAL AND METHODS: The study included a total of 80 subjects, men and women, divided into two groups: an examined group (n = 50) consisting of subjects with DPN at the age from 30 to 80 years and a control group (n = 30) of healthy subjects aged from 18 to 45. In the investigated group, a neurological examination was performed using the Diabetic Neuropathy Symptoms (DNS) Score and Electroneurography. All the subjects had the blood plasma concentration of TNF-α by ELISA technique. RESULTS: The average value of TNF-α in the test group was 8.24 ± 2.899 pg/ml, while the control group was 4.36 ± 2.622 pg/ml (p < 0.0001). The average value of TNF-α was correlated with the achieved DNS score in the investigated group (p = 0.005). Concerning the linear association of the concentration of TNF-α with the peripheral nerve velocity in the investigated group, no statistical significance was detected. CONCLUSION: Inflammation can play a role in the pathogenesis of diabetic autonomic neuropathy and cranial neuritis.

scholarly journals Persistent Neuropathy in Lepromatous Leprosy Patients

2021 ◽  
Author(s):  
Patricia Penna ◽  
Robson Vital ◽  
IZABELA PITTA ◽  
Mariana Hacker ◽  
Ana Salles ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Peripheral Nerve ◽  
Nerve Biopsy ◽  
Lepromatous Leprosy ◽  
Nerve Damage ◽  
Sensory Nerves ◽  
High Dose ◽  
Peripheral Nerve Damage ◽  
End Of Treatment ◽  
Leprosy Patients

Abstract Lepromatous leprosy (LL) patients have evidence of extensive peripheral nerve damage as soon as a diagnosis is made, but most of them have few or no symptoms related to peripheral neuropathy. Usually, they do not have the cardinal signal of leprosy neuritis. However, disability caused by peripheral nerve injuries has consequences throughout the entire life of these patients and the pathophysiological mechanisms of nerve damage are still poorly understood. The objective of this study was to evaluate the outcome of peripheral neuropathy in a group of LL patients in an attempt to understand the mechanisms of nerve damage. We evaluated medical records of 14 LL patients that had undergone a neurological evaluation at the beginning of Leprosy treatment then worsened at least 4 years after the end of treatment and underwent nerve biopsy. The symptoms at the beginning of treatment were compared with those at the time of the biopsy. Pain was a symptom in only one patient at the beginning and was a complaint in 9 patients by the time of biopsy. Neurological examination showed that the majority of patients already had alterations in medium and large caliber fibers at the beginning of the treatment, and pain increased by the time of biopsy, while neurological symptoms and signs deteriorated independently of the use of prednisone or thalidomide. Nerve Conduction Studies demonstrated that sensory nerves were the most affected. LL patients can develop a silent progressive degenerative peripheral neuropathy, which continues to develop despite high dose long term corticoid therapy.

Focal peripheral neuropathy

2011 ◽  
Author(s):  
Michael Donaghy
Keyword(s):  
Peripheral Nerve ◽  
Immunosuppressive Treatment ◽  
Conduction Block ◽  
Multifocal Motor Neuropathy ◽  
Nerve Damage ◽  
High Dose ◽  
Motor Neuropathy ◽  
Peripheral Nerve Damage ◽  
Entrapment Neuropathies ◽  
Focal Neuropathy

Some causes of focal peripheral nerve damage are self-evident, such as involvement at sites of trauma, tissue necrosis, infiltration by tumour, or damage by radiotherapy. Focal compressive and entrapment neuropathies are particularly valuable to identify in civilian practice, since recovery may follow relief of the compression. Leprosy is a common global cause of focal neuropathy, which involves prominent loss of pain sensation with secondary acromutilation, and requires early antibiotic treatment. Mononeuritis multiplex due to vasculitis requires prompt diagnosis and immunosuppressive treatment to limit the severity and extent of peripheral nerve damage. Various other medical conditions, both inherited and acquired, can present with focal neuropathy rather than polyneuropathy, the most common of which are diabetes mellitus and hereditary liability to pressure palsies. A purely motor focal presentation should raise the question of multifocal motor neuropathy with conduction block, which usually responds well to high-dose intravenous immunoglobulin infusions.

scholarly journals Association of Serum Cholesterol Levels With Peripheral Nerve Damage in Patients With Type 2 Diabetes

2019 ◽  
Vol 2 (5) ◽  
pp. e194798 ◽  
Author(s):  
Johann M. E. Jende ◽  
Jan B. Groener ◽  
Christian Rother ◽  
Zoltan Kender ◽  
Artur Hahn ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Peripheral Nerve ◽  
Serum Cholesterol ◽  
Nerve Damage ◽  
Peripheral Nerve Damage ◽  
Cholesterol Levels

scholarly journals Ipsilateral cortical fMRI responses after peripheral nerve damage in rats reflect increased interneuron activity

2009 ◽  
Vol 106 (33) ◽  
pp. 14114-14119 ◽  
Author(s):  
G. Pelled ◽  
D. A. Bergstrom ◽  
P. L. Tierney ◽  
R. S. Conroy ◽  
K.-H. Chuang ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Nerve Damage ◽  
Peripheral Nerve Damage ◽  
Interneuron Activity

scholarly journals Photobiostimulation reverses allodynia and peripheral nerve damage in streptozotocin-induced type 1 diabetes

2017 ◽  
Vol 32 (3) ◽  
pp. 495-501 ◽  
Author(s):  
Igor Rafael Correia Rocha ◽  
Adriano Polican Ciena ◽  
Alyne Santana Rosa ◽  
Daniel Oliveira Martins ◽  
Marucia Chacur
Keyword(s):  
Type 1 Diabetes ◽  
Peripheral Nerve ◽  
Nerve Damage ◽  
Peripheral Nerve Damage
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