Effects of Electromagnetic Field Exposure During the Prenatal Period on Biomarkers of Oxidative Stress and Pathology of Testis and Testosterone Level of Adult Rats in F1 Generation

2014 ◽  
Vol 10 (4) ◽  
pp. 577-587 ◽  
Author(s):  
H Gharamaleki
Keyword(s):  
Oxidative Stress ◽  
Electromagnetic Field ◽  
Testosterone Level ◽  
Prenatal Period ◽  
Field Exposure ◽  
Adult Rats ◽  
F1 Generation ◽  
Biomarkers Of Oxidative Stress

scholarly journals Effects of prenatal exposure to electromagnetic fields on biomarkers of oxidative stress and fertility of F1 generation In-vitro

2014 ◽  
Vol 15 (3) ◽  
pp. 165-169
Author(s):  
Jafar Soleimani Rad ◽  
Leila Roshangar ◽  
Hamideh Gharamaleki ◽  
Akram Valipoor ◽  
Kaveh Kazemi Kia
Keyword(s):  
Oxidative Stress ◽  
Electromagnetic Field ◽  
Treatment Group ◽  
Prenatal Period ◽  
Cleavage Pattern ◽  
Pregnant Rats ◽  
And Control ◽  
F1 Generation ◽  
Biomarkers Of Oxidative Stress

The aim of the present study was to evaluate the effects of Electromagnetic Field (EMF) in the prenatal period on biomarkers of oxidative stress and fertility of F1 generation. Material and Methods: The pregnant rats divided to 3 group’s treatment (EMF exposure), Sham (off -EMF) and control. After delivery the blood sample of mothers provided and pups were kept until maturity age, and then their fertility was investigated. Results: CAT in treatment group was significantly decreased but no differences in GPX were observed. In treatment group decrease in multicellular embryos and abnormality in cleavage pattern was found. Conclusion: Exposure in EMF cause oxidative stress and reduce fertility.

scholarly journals Neuronal Cellular Responses to Extremely Low Frequency Electromagnetic Field Exposure: Implications Regarding Oxidative Stress and Neurodegeneration

PLoS ONE ◽  
2014 ◽  
Vol 9 (8) ◽  
pp. e104973 ◽  
Author(s):  
Marcella Reale ◽  
Mohammad A. Kamal ◽  
Antonia Patruno ◽  
Erica Costantini ◽  
Chiara D'Angelo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Electromagnetic Field ◽  
Low Frequency ◽  
Cellular Responses ◽  
Field Exposure ◽  
Extremely Low Frequency

Physical exercise protects dynamic balance and motor coordination of rats treated with vincristine

2020 ◽  
Vol 19 (5) ◽  
pp. 336
Author(s):  
Luiza Minato Sagrillo ◽  
Viviane Nogueira De Zorzi ◽  
Luiz Fernando Freire Royes ◽  
Michele Rechia Fighera ◽  
Beatriz Da Silva Rosa Bonadiman ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Locomotor Activity ◽  
Physical Exercise ◽  
Motor Coordination ◽  
Dynamic Balance ◽  
Exercise Group ◽  
Adult Rats ◽  
The Central Nervous System ◽  
Stress Damage ◽  
Training Protocol

Physical exercise has been shown to be an important modulator of the antioxidant system and neuroprotective in several diseases and treatments that affect the central nervous system. In this sense, the present study aimed to evaluate the effect of physical exercise in dynamic balance, motor coordination, exploratory locomotor activity and in the oxidative and immunological balance of rats treated with vincristine (VCR). For that, 40 adult rats were divided into two groups: exercise group (6 weeks of swimming, 1h/day, 5 days/week, with overload of 5% of body weight) and sedentary group. After training, rats were treated with 0.5 mg/kg of vincristine sulfate for two weeks or with the same dose of 0.9% NaCl. The behavioral tests were conducted 1 and 7 days after each dose of VCR. On day 15 we carried out the biochemical analyzes of the cerebellum. The physical exercise was able to protect against the loss of dynamic balance and motor coordination and, had effect per se in the exploratory locomotor activity, and neutralize oxidative stress, damage DNA and immune damage caused by VCR up to 15 days after the end of the training protocol. In conclusion, we observed that previous physical training protects of the damage motor induced by vincristine.Key-words: exercise, oxidative stress, neuroprotection, cerebellum.

The Impact of L-Carnitine and Coenzyme Q10 as Protection Against Busulfan-Oxidative Stress in the Liver of Adult Rats

2020 ◽  
Vol 10 (5) ◽  
pp. 578-586
Author(s):  
Areeg M. Abdelrazek ◽  
Shimaa A. Haredy
Keyword(s):  
Oxidative Stress ◽  
Coenzyme Q10 ◽  
Protective Role ◽  
Albino Rats ◽  
Distilled Water ◽  
Negative Effects ◽  
Adult Rats ◽  
Stress Damage ◽  
The Impact ◽  
Liver Tissues

Background: Busulfan (Bu) is an anticancer drug with a variety of adverse effects for cancer patients. Oxidative stress has been considered as a common pathological mechanism and it has a key role in the initiation and progression of liver injury by Bu. Aim: The study aimed to evaluate the antioxidant impact of L-Carnitine and Coenzyme Q10 and their protective role against oxidative stress damage in liver tissues. Methods and Material: Thirty-six albino rats were divided equally into six groups. G1 (con), received I.P. injection of DMSO plus 1 ml of distilled water daily by oral gavages; G2 (Bu), received I.P. injection of Bu plus 1 ml of the distilled water daily; G3 (L-Car), received 1 ml of L-Car orally; G4 (Bu + L-Car) received I.P. injection of Bu plus 1 ml of L-Car, G5 (CoQ10) 1 ml of CoQ10 daily; and G6 (Bu + CoQ10) received I.P. injection of Bu plus 1 ml of CoQ10 daily. Results: The recent data showed that Bu induced significant (P<0.05) elevation in serum ALT, AST, liver GSSG, NO, MDA and 8-OHDG, while showing significant (P<0.05) decrease in liver GSH and ATP. On the other hand, L-Carnitine and Coenzyme Q10 ameliorated the negative effects prompted by Bu. Immunohistochemical expression of caspase-3 in liver tissues reported pathological alterations in Bu group while also showed significant recovery in L-Car more than CoQ10. Conclusion: L-Car, as well as CoQ10, can enhance the hepatotoxic effects of Bu by promoting energy production in oxidative phosphorylation process and by scavenging the free radicals.

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