scholarly journals The role of vitamin D deficiency on the Covid-19: A systematic review and meta-analysis of observational studies

2021 ◽  
pp. e2021074
Author(s):  
Mehmet Onur Kaya ◽  
Esra Pamukçu ◽  
Burkay Yakar
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Observational Studies ◽  
Meta Analysis

scholarly journals Prognostic and therapeutic role of vitamin D in COVID-19: systematic review and meta-analysis

2021 ◽  
Author(s):  
Harsha Anuruddhika Dissanayake ◽  
Nipun Lakshitha de Silva ◽  
Manilka Sumanatilleke ◽  
Sawanawadu Dilantha Neomal de Silva ◽  
Kavinga Kalhari Kobawaka Gamage ◽  
...  
Keyword(s):  
Vitamin D ◽  
High Risk ◽  
Vitamin D Deficiency ◽  
Observational Studies ◽  
Meta Analysis ◽  
Severe Disease ◽  
Risk Of Bias ◽  
Sensitivity Analyses ◽  
Cochrane Library

Abstract Purpose Vitamin D deficiency/insufficiency may increase the susceptibility to COVID-19. We aimed to determine the association between vitamin D deficiency/insufficiency and susceptibility to COVID-19, its severity, mortality and role of vitamin D in its treatment. Methods We searched CINHAL, Cochrane library, EMBASE, PubMED, Scopus, and Web of Science up to 30.05.2021 for observational studies on association between vitamin D deficiency/insufficiency and susceptibility to COVID-19, severe disease and death among adults, and, randomized controlled trials (RCTs) comparing vitamin D treatment against standard care or placebo, in improving severity or mortality among adults with COVID-19. Risk of bias was assessed using Newcastle-Ottawa scale for observational studies and AUB-KQ1 Cochrane tool for RCTs. Study-level data were analyzed using RevMan 5.3 and R (v4∙1∙0). Heterogeneity was determined by I  2 and sources were explored through pre-specified sensitivity analyses, subgroup analyses and meta-regressions. Results Of 1877 search results, 76 studies satisfying eligibility criteria were included. Seventy-two observational studies were included in the meta-analysis (n=1976099). Vitamin D deficiency/insufficiency increased the odds of developing COVID-19 (OR 1∙46, 95% CI 1∙28–1∙65, p<0∙0001, I  2=92%), severe disease (OR 1∙90, 95% CI 1∙52–2∙38, p<0.0001, I  2=81%) and death (OR 2∙07, 95% CI 1∙28–3∙35, p=0.003, I  2=73%). 25-hydroxy vitamin D (25(OH)D) concentration were lower in individuals with COVID-19 compared to controls (mean difference [MD] -3∙85 ng/mL, 95% CI -5∙44,-2∙26, p=<0.0001), in patients with severe COVID-19 compared to controls with non-severe COVID19 (MD -4∙84 ng/mL, 95% CI -7∙32,-2∙35, p=0∙0001) and in non-survivors compared to survivors (MD -4∙80 ng/mL, 95%-CI -7∙89,-1∙71, p=0∙002). The association between vitamin D deficiency/insufficiency and death was insignificant when studies with high risk of bias or studies reporting unadjusted effect estimates were excluded. Risk of bias and heterogeneity were high across all analyses. Discrepancies in timing of vitamin D testing, definitions of severe COVID-19 and vitamin D deficiency/insufficiency partly explained the heterogeneity. Four RCTs were widely heterogeneous precluding meta-analysis. Conclusion Multiple observational studies involving nearly two million adults suggest vitamin D deficiency/insufficiency increases susceptibility to COVID-19 and severe COVID-19, although with a high risk of bias and heterogeneity. Association with mortality was less robust. Heterogeneity in RCTs precluded their meta-analysis.

scholarly journals The Role of Vitamin D in The Age of COVID-19: A Systematic Review and Meta-Analysis

2020 ◽  
Author(s):  
Roya Ghasemian ◽  
Amir Shamshirian ◽  
Keyvan Heydari ◽  
Mohammad Malekan ◽  
Reza Alizadeh-Navaei ◽  
...  
Keyword(s):  
Systematic Review ◽  
Chronic Kidney Disease ◽  
Vitamin D ◽  
Cardiovascular Diseases ◽  
Vitamin D Deficiency ◽  
Respiratory Diseases ◽  
Meta Analysis ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

AbstractBackgroundEvidence recommends that vitamin D might be a crucial supportive agent for the immune system, mainly in cytokine response regulation against COVID-19. Hence, we carried out a systematic review and meta-analysis in order to maximize the use of everything that exists about the role of vitamin D in the COVID-19.MethodsA systematic search was performed in PubMed, Scopus, Embase, Cochrane Library, Web of Science, and Google Scholar (intitle) as well as preprint database of medRxiv, bioRxiv, Research Square, preprints.org, and search engine of ScienceDirect up to October 10, 2020. Studies focused on the role of vitamin D in confirmed COVID-19 patients were entered into the systematic review.ResultsSixteen studies containing 4922 participants entered into the meta-analysis. The meta-analysis indicated that 48% of COVID-19 patients were suffering from vitamin D deficiency (95% CI, 29%-67%), and in 41% of patients, levels of vitamin D were insufficient (95% CI, 10%-82%). The serum 25-hydroxyvitamin D concentration was 18 ng/mL among all COVID-19 patients (95% CI, 13-24). Co-morbidities frequency in COVID-19 patients were as follows: 7.4% cancer, 27.1% chronic kidney disease, 30.4% cardiovascular diseases, 5.1% dementia, 14.5% depression/anxiety, 32.1% diabetes, 47.4% hypertension, 22.0% obesity and 17.5% respiratory diseases. Reported ethnic groups in studies were 1.0% Afro-Caribbean, 10.3% Asian, and 92.1% Caucasian.ConclusionThis study found that the mean serum 25-hydroxyvitamin D level was low in all COVID-19 patients, and most of them were suffering from vitamin D deficiency/insufficiency. The Caucasian was the dominant ethnic group, and the most frequent co-morbidities in COVID-19 patients were hypertension, cardiovascular diseases, chronic kidney disease, diabetes, obesity, and respiratory diseases, which might be affected by vitamin D deficiency directly or indirectly.

Vitamin D deficiency and Schizophrenia in Adults: A Systematic Review and Meta-analysis of Observational Studies

2020 ◽  
Vol 288 ◽  
pp. 112959 ◽  
Author(s):  
Jia-lian Zhu ◽  
Wen-wen Luo ◽  
Xuan Cheng ◽  
Yun Li ◽  
Qi-zhi Zhang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Observational Studies ◽  
Meta Analysis

scholarly journals Therapeutic and prognostic role of vitamin D for COVID-19 infection: A systematic review and meta-analysis of 43 observational studies

2021 ◽  
Vol 211 ◽  
pp. 105883
Author(s):  
Fausto Petrelli ◽  
Andrea Luciani ◽  
Gianluca Perego ◽  
Giuseppina Dognini ◽  
Paolo Luigi Colombelli ◽  
...  
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Observational Studies ◽  
Meta Analysis ◽  
Prognostic Role

scholarly journals Pooled estimate of vitamin D deficiency among pregnant women in India: a systematic review and meta-analysis

2021 ◽  
Vol 40 (1) ◽  
Author(s):  
Angeline Jeyakumar ◽  
Vidhya Shinde ◽  
Reshma Ravindran
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Pregnant Women ◽  
Vitamin D Deficiency ◽  
Meta Analysis ◽  
Health Concern ◽  
Study Quality ◽  
Care Services ◽  
Pooled Prevalence ◽  
Women In India

Abstract Background Vitamin D deficiency among pregnant women is a public health concern globally. In India, individual studies report high prevalence. However, lack of national data masks the true burden. This work determined the pooled prevalence of vitamin D deficiency among pregnant women in India through a systematic review of literature and meta-analysis. Methods Three different search engines yielded 15 eligible articles. Study quality was assessed by 10 different criteria and summary of study quality was categorized as per Cochrane standards. Meta-analysis was performed to estimate pooled prevalence of vitamin D deficiency among healthy pregnant women and heterogeneity among selected studies. A sample of n = 4088 was used to study the pooled prevalence among pregnant women. Results The random effects combined estimate was 32.35% (95% CI, (12.58–117.48). High heterogeneity (tau2 = 0.39, I2 = 100%) and high risk of bias was observed among the selected studies. The test for overall effect was observed to be z = 2.54(P = 0.01). Conclusion Pooled estimate > 30% emphasizes the need for screening through antenatal care services and initiate preventive measures to address the deficiency.

Risk Factors for Vitamin D Deficiency in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 32 (6) ◽  
pp. 508-518
Author(s):  
Shanzhen Shi ◽  
◽  
Jiaxing Feng ◽  
Lixiang Zhou ◽  
Yu Li ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Inflammatory Bowel Disease ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Bowel Disease ◽  
Meta Analysis ◽  
Inflammatory Bowel
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