scholarly journals Adjusting for reverse causation to estimate the effect of obesity on mortality after incident heart failure in the Atherosclerosis Risk in Communities (ARIC) study

2016 ◽  
Vol 38 ◽  
pp. e2016025 ◽  
Author(s):  
Maryam Shakiba ◽  
Hamid Soori ◽  
Mohammad Ali Mansournia ◽  
Seyed Saeed Hashemi Nazari ◽  
Yahya Salimi
Keyword(s):  
Heart Failure ◽  
Reverse Causation ◽  
Atherosclerosis Risk In Communities ◽  
Atherosclerosis Risk ◽  
Incident Heart Failure ◽  
Aric Study

scholarly journals Mitochondrial DNA copy number and incident heart failure: The Atherosclerosis Risk in Communities (ARIC) study

2019 ◽  
Author(s):  
Yun Soo Hong ◽  
Ryan J. Longchamps ◽  
Di Zhao ◽  
Christina A. Castellani ◽  
Laura R. Loehr ◽  
...  
Keyword(s):  
Heart Failure ◽  
Mitochondrial Dna ◽  
Ejection Fraction ◽  
Copy Number ◽  
Dna Copy Number ◽  
Atherosclerosis Risk In Communities ◽  
Mitochondrial Dna Copy Number ◽  
Atherosclerosis Risk ◽  
Incident Heart Failure ◽  
Aric Study

ABSTRACTBackgroundThe association between mitochondrial DNA-copy number (mtDNA-CN) and incident heart failure (HF) in the general population is unclear.MethodsWe examined the association between mtDNA-CN and the risk of incident HF among 10,802 participants free of HF at baseline from the Atherosclerosis Risk in Communities (ARIC) study, a large bi-racial population-based cohort. mtDNA-CN was estimated using probe intensities on the Affymetrix Genome-Wide Human single nucleotide polymorphisms Array 6.0. Incident HF events were identified through hospital discharge codes from 1987 until 2005 and through adjudication by the ARIC HF Classification Committee since 2005.ResultsDuring a median follow-up of 23.1 years, there were 2,227 incident HF events (incidence rate 10.3 per 1000 person-years). In fully adjusted models, the hazard ratios (95% confidence intervals) for HF comparing the 2nd through 5th quintiles of mtDNA-CN to the 1st quintile were 0.91 (0.80–1.04), 0.82 (0.72–0.93), 0.81 (0.71–0.92), and 0.74 (0.65–0.85), respectively (P for trend < 0.001). In stratified analyses, the associations between mtDNA-CN and HF were similar across examined subgroups. The inverse association between mtDNA-CN and incident HF was stronger in HF with reduced ejection fraction (HFrEF) than in HF with preserved ejection fraction (HFpEF).ConclusionsIn this prospective cohort, mtDNA-CN was inversely associated with the risk of incident HF suggesting that reduced levels of mtDNA-CN, a biomarker of mitochondrial dysfunction, could reflect early susceptibility to HF.

scholarly journals Airflow obstruction, lung function, and risk of incident heart failure: the Atherosclerosis Risk in Communities (ARIC) study

2012 ◽  
Vol 14 (4) ◽  
pp. 414-422 ◽  
Author(s):  
Sunil K. Agarwal ◽  
Gerardo Heiss ◽  
R. Graham Barr ◽  
Patricia P. Chang ◽  
Laura R. Loehr ◽  
...  
Keyword(s):  
Heart Failure ◽  
Lung Function ◽  
Airflow Obstruction ◽  
Atherosclerosis Risk In Communities ◽  
Atherosclerosis Risk ◽  
Incident Heart Failure ◽  
Aric Study

scholarly journals Reduced Kidney Function as a Risk Factor for Incident Heart Failure: The Atherosclerosis Risk in Communities (ARIC) Study

2007 ◽  
Vol 18 (4) ◽  
pp. 1307-1315 ◽  
Author(s):  
Anna Kottgen ◽  
Stuart D. Russell ◽  
Laura R. Loehr ◽  
Ciprian M. Crainiceanu ◽  
Wayne D. Rosamond ◽  
...  
Keyword(s):  
Heart Failure ◽  
Risk Factor ◽  
Kidney Function ◽  
Atherosclerosis Risk In Communities ◽  
Atherosclerosis Risk ◽  
Incident Heart Failure ◽  
Reduced Kidney Function ◽  
Aric Study

Abstract MP36: Anemia, Chronic Kidney Disease, and Incident Heart Failure: The Atherosclerosis Risk in Communities (ARIC) Study

Circulation ◽  
2016 ◽  
Vol 133 (suppl_1) ◽  
Author(s):  
Junichi Ishigami ◽  
Morgan E Grams ◽  
Rakhi P Naik ◽  
Melissa C Caughey ◽  
Laura R Loehr ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Cross Sectional ◽  
Atherosclerosis Risk In Communities ◽  
Increased Risk ◽  
Atherosclerosis Risk ◽  
Incident Heart Failure ◽  
Aric Study ◽  
Prevalence Of Anemia

Background: Both chronic kidney disease (CKD) measures, estimated glomerular filtration rate (eGFR) and albumin-to-creatinine ratio (ACR), are associated with incident heart failure (HF). Anemia is thought to play an important role in this association, particularly when eGFR is reduced, but this concept has not been rigorously evaluated. Methods: Using data from 5,539 participants in the Atherosclerosis Risk in Communities (ARIC) study at the fourth visit (1996-98), we first assessed the prevalence ratio (PrR) of anemia for eGFR and ACR using cross-sectional Poisson models, and then prospectively quantified the associations of eGFR, ACR, and anemia with incident HF using Cox proportional hazard models. Results: Based on the WHO definition, 477 (8.6%) participants had anemia at baseline. Both CKD measures were associated with increased prevalence of anemia independently of each other and other potential confounders (PrR, 1.22 [95% confidence interval, 1.11-1.34] with every 1SD decrease in eGFR; and 1.12 [1.03-1.23] with every 1SD increase in log 10 ACR). There were 724 (13.1%) cases of incident HF over median follow-up of 14.8 years. Lower eGFR and higher ACR were independently associated with increased risk of HF regardless of anemia status (Figure A for eGFR, and B for ACR). The association between anemia and HF risk was generally consistent in the range of eGFR below 90 ml/min/1.73m 2 and ACR between 5 and 300 mg/g, without significant interaction between both CKD measures and anemic status (e.g., hazard ratio for anemia vs. no anemia: 1.40 [0.81-2.41] at eGFR 60 ml/min/1.73m 2 and 1.37 [0.67-2.80] at ACR 30 mg/g). Conclusions: Reduced eGFR and elevated ACR were independently associated with higher prevalence of anemia and HF risk. The contribution of anemia to HF risk was overall consistent across CKD ranges of eGFR and ACR. Our results suggest the need of clinical attention on anemia and related HF risk in persons with low eGFR as well as those with high ACR.

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