scholarly journals Antiproliferative and Apoptosis-inducing Effects of Abrus precatorius Against Human Monocytic Leukaemia (THP-1) Cell Line

2018 ◽  
Vol 80 (2) ◽  
Author(s):  
M Z Gul ◽  
S Chandrasekaran ◽  
K Manjulatha ◽  
M Y Bhat ◽  
R Maurya ◽  
...  
Keyword(s):  
Cell Line ◽  
Abrus Precatorius ◽  
Monocytic Leukaemia

scholarly journals Cytotoxic and pro-apoptotic effects of Abrus precatorius L. on human metastatic breast cancer cell line, MDA-MB-231

2012 ◽  
Vol 65 (3) ◽  
pp. 407-417 ◽  
Author(s):  
Mohammed Shafi Sofi ◽  
M. K. Sateesh ◽  
Mohsin Bashir ◽  
G. Harish ◽  
T. R. Lakshmeesha ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Breast Cancer Cell Line ◽  
Metastatic Breast ◽  
Cancer Cell Line ◽  
Abrus Precatorius ◽  
Apoptotic Effects

scholarly journals Study of the action mechanisms of Arnica montana effects on macrophages

2021 ◽  
Vol 15 (4) ◽  
pp. 32-35
Author(s):  
Marta Marzotto ◽  
Clara Bonafini ◽  
Debora Olioso ◽  
Paolo Bellavite
Keyword(s):  
Extracellular Matrix ◽  
Cell Line ◽  
Quantitative Evaluation ◽  
Leukaemia Cell ◽  
Leukaemia Cell Line ◽  
Human Macrophages ◽  
Arnica Montana ◽  
Action Mechanisms ◽  
Differentiating Agents ◽  
Monocytic Leukaemia

Objective: To test the effect of Arnica montana (Arnica m.) on human macrophages. Method: The human monocytic leukaemia cell line THP-1 was cultured and differentiated in mature macrophages with PMA and other differentiating agents. Macrophages were exposed to Arnica m. homeopathic dilutions (2c, 3c, 5c, 9c and 15c) or Control solvent. Total RNA was isolated and sequenced to perform quantitative evaluation. Results: Screening sorted out with a list of 20 genes that were significantly changed by Arnica m. 2c treatment: 7 up-regulated and 13 down-regulated. Most notably, a clearly up-regulated function concerned the proteinaceous extracellular matrix (ECM), including genes HSPG2, FBN2, FN1 (p

scholarly journals Protein kinase C-ζ overexpression induces erythroid phenotype in the monocytic leukaemia cell line U937

2002 ◽  
Vol 118 (2) ◽  
pp. 646-653 ◽  
Author(s):  
Véronique Mansat-De Mas ◽  
Aurélie De Thonel ◽  
Vanessa Gaulin ◽  
Cécile Demur ◽  
Guy Laurent ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Cell Line ◽  
Leukaemia Cell ◽  
Leukaemia Cell Line ◽  
Kinase C ◽  
Monocytic Leukaemia

scholarly journals Cytotoxic Effect of Ethanol Extract of Abrus precatorius Leaves on Raw 264.7 and SK-N-SH Cell lines

2021 ◽  
pp. 195-206
Author(s):  
Krishnaprabha Naduchamy ◽  
Varadarajan Parthasarathy
Keyword(s):  
Cell Line ◽  
Cell Lines ◽  
Cytotoxic Effect ◽  
Picolinic Acid ◽  
Ethanol Extract ◽  
Human Neuroblastoma Cell ◽  
Raw 264.7 ◽  
Human Neuroblastoma ◽  
Abrus Precatorius ◽  
Raw 264.7 Cell

Aim: This study was aimed to investigate the cytotoxic effect of ethanol extract of Abrus precatorius. leaves on Raw 264.7 and SK-N-SH cell lines. Methodology: Soxhlet extraction was carried out using absolute alcohol and subsequently, the profiling of phytoconstituents of ethanol extract was performed by LC-MS analysis. Results: The results showed that the presence of anthocyanin, phenolic acid, carboxylic acid, amino acid and monoester in ethanol extract of Abrus precatorius. The phytoconstituents such as picolinic acid, N-Acetyl-DL-tryptophan, 3-Hydroxybenzoic acid, kuromanin, aflatoxin G2, monobutyl Phthalate, laurolactam, 4-Dodecylbenzenesulfonic acid, 4-Methoxycinnamic acid, caffeic acid and octyl decyl phthalate were found  in ethanol extract. In addition to this, the cytotoxic effect of the ethanol extract was tested on Raw 264.7 and SK-N-SH cell lines using MTT assay. The cytotoxic study revealed that the ethanol extract of Abrus precatorius was non-toxic to Raw 264.7 cell, but it showed a toxic effect on human neuroblastoma cell line, SK-N-SH. Conclusion: In this study, it was observed that the ethanol extract of Abrus precatorius was non-toxic to Raw 264.7 cell line, but it exhibited strong inhibition on the viability of SK-N-SH cell line.

Expression of surface markers on the human monocytic leukaemia cell line, THP-1, as indicators for the sensitizing potential of chemicals

2009 ◽  
Vol 60 (4) ◽  
pp. 185-192 ◽  
Author(s):  
Susun An ◽  
Seoyoung Kim ◽  
Yong Huh ◽  
Tae Ryong Lee ◽  
Han-Kon Kim ◽  
...  
Keyword(s):  
Cell Line ◽  
Surface Markers ◽  
Leukaemia Cell ◽  
Leukaemia Cell Line ◽  
Monocytic Leukaemia

Interactions between the human monocytic leukaemia THP-1 cell line and Old and New World species of Leishmania

Acta Tropica ◽  
1990 ◽  
Vol 47 (3) ◽  
pp. 171-176 ◽  
Author(s):  
B.W. Ogunkolade ◽  
Isabelle Colomb-Valet ◽  
L. Monjour ◽  
Alice Rhodes-Feuillette ◽  
J.P. Abita ◽  
...  
Keyword(s):  
Cell Line ◽  
New World ◽  
World Species ◽  
Monocytic Leukaemia

Ultrastructure of NPC/HK1 cells heterotransplanted in athymic nude mice

1982 ◽  
Vol 40 ◽  
pp. 236-237
Author(s):  
E.C. Chew ◽  
C.L. Li ◽  
D.P. Huang ◽  
H.C. Ho ◽  
L.S. Mak ◽  
...  
Keyword(s):  
Cell Line ◽  
Nude Mice ◽  
Biopsy Specimen ◽  
Epithelial Cell Line ◽  
Present Communication ◽  
Recurrent Tumour ◽  
Athymic Nude Mice ◽  
Cell Line Establishment ◽  
Fine Structures ◽  
Well Differentiated

An epithelial cell line, NPC/HK1, has recently been established from a biopsy specimen of a recurrent tumour of the nasopharynx which was histologically diagnosed as a moderately to well differentiated squamous cell carcinoma. A definite decrease in the amount of tonofilaments and desmosomes in the NPC/HK1 cells during the cell line establishment was observed. The present communication reports on the fine structures of the NPC/HK1 cells heterotraneplanted in athymic nude mice.

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