Phenolic Composition, Antioxidant and Cytotoxic Activities of Prospero autumnale

R Mammadov; A Kaska; C Ozay

doi:10.4172/pharmaceutical-sciences.1000266

Contribution of Major Polyphenols to the Antioxidant Profile and Cytotoxic Activity of Olive Leaves

Anti-Cancer Agents in Medicinal Chemistry ◽

10.2174/1871520619666190416101622 ◽

2019 ◽

Vol 19 (13) ◽

pp. 1651-1657

Author(s):

Zouhaier Bouallagui ◽

Asma Mahmoudi ◽

Amina Maalej ◽

Fatma Hadrich ◽

Hiroko Isoda ◽

...

Keyword(s):

Antioxidant Activity ◽

Hepg2 Cells ◽

Cytotoxic Activities ◽

Phenolic Composition ◽

Olive Leaves ◽

Total Polyphenols ◽

Cytotoxic Effects ◽

Antioxidant Profile ◽

Phytochemical Profile ◽

Mcf 7

Aim: This study was designed to investigate the phytochemical profile and the cytotoxic activities of the eco-friendly extracts of olive leaves from Chemlali cultivar. Materials and Methods: The Phenolic composition of olive leaves extracts, the antioxidant activity and the cytotoxic effects against MCF-7 and HepG2 cells were determined. Results: Olive leaves extracts showed relevant total polyphenols contents. Oleuropein was the major detected phenolic compound reaching a concentration of 16.9 mg/ml. The antioxidant potential of the studied extracts varied from 23.7 to 46.5mM Trolox equivalents as revealed by DPPH and ABTS assays. Cytotoxicity experiments showed similar trends for both HepG2 and MCF-7 cells with the infusion extract being the most active. Conclusion: This study denotes that olive leaves may have great potential as endless bioresource of valuable bioactive compounds which may have a wide application.

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Evaluation of bioactivities and phenolic composition of extracts of Salvia officinalis L. (Lamiaceae) collected in Montenegro

Botanica Serbica ◽

10.2298/botserb1901047d ◽

2019 ◽

Vol 43 (1) ◽

pp. 47-58 ◽

Cited By ~ 1

Author(s):

Sonja Duletic-Lausevic ◽

Ana Alimpic-Aradski ◽

Jelena Zivkovic ◽

Nevenka Gligorijevic ◽

Katarina Savikin ◽

...

Keyword(s):

Coastal Region ◽

Salvia Officinalis ◽

Total Phenolic ◽

Cytotoxic Activities ◽

Strongly Correlated ◽

Phenolic Composition ◽

Continental Part ◽

Ethanol Extracts ◽

Salvia Officinalis L ◽

Phenolic And Flavonoid

Sage (Salvia officinalis) is the best-known species of the genus Salvia, due to its medicinal and flavouring properties. This research was conducted on samples of S. officinalis collected from Potoci (SOP) in the continental part of Montenegro and from Valdanos (SOV) and Lustica (SOL) in the country?s coastal region. Extracts prepared using 96% ethanol, 50% ethanol and hot distilled water were examined for phenolic composition, as well as for their antioxidant, enzyme-inhibiting and cytotoxic activities. The HPLC-DAD method was employed for quantitative-qualitative analysis of phenolic compounds in extracts, which confirmed the presence of rosmarinic and caffeic acids and luteolin-7-O-glucoside. Total phenolic and flavonoid contents, antioxidant activity, and inhibition of acetylcholinesterase and tyrosinase were measured spectrophotometrically. In the applied antioxidant tests (DPPH, FRAP and ?-carotene/linoleic acid tests) and tests of inhibition of the enzymes acetylcholinesterase and tyrosinase, the SOP extracts showed stronger antioxidant and enzyme-inhibiting activities compared to SOV and SOL, while the most efficient solvent was 50% ethanol. The highest cytotoxic activity in the MTT test was recorded for 96% ethanol extracts, especially in the case of the SOL sample, against the A375 cell line. All of the tested bioactivities were more strongly correlated with total phenolic content than with flavonoid content. Differences in the tested bioactivities of extracts obtained from plants collected at ecologically different localities and with different extraction solvents could be explained by variations in total phenolic and flavonoid contents.

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The correlation between the phenolic composition and biological activities of two varieties of Brazilian propolis (G6 and G12)

Brazilian Journal of Pharmaceutical Sciences ◽

10.1590/s1984-82502012000300023 ◽

2012 ◽

Vol 48 (3) ◽

pp. 557-564 ◽

Cited By ~ 19

Author(s):

Ingridy Simone Ribeiro Cabral ◽

Tatiane Luiza Cadorin Oldoni ◽

Severino Matias de Alencar ◽

Pedro Luiz Rosalen ◽

Masaharu Ikegaki

Keyword(s):

Biological Activity ◽

Biological Activities ◽

Cytotoxic Activities ◽

Phenolic Composition ◽

Flavonoid Content ◽

Biological Assays ◽

Different Types ◽

Brazilian Propolis ◽

Strong Antimicrobial Activity

Biological assays that have been performed on different types of Brazilian propolis have shown that type 6 propolis (G6) has a strong antimicrobial activity and a low flavonoid content. This study aimed to evaluate the correlation between the phenolic composition and the biological activities displayed by propolis G6 from the state of Bahia and green propolis, also known as type 12 (G12). The values of the flavonoids and the total phenolics in propolis G6 were different than those in propolis G12. Although the G12 variety presented greater antioxidant activity, propolis G6 proved to have greater antimicrobial and cytotoxic activities. The results showed that the phenolic compounds may not be the only compounds responsible for the biological activity. More detailed studies of the chemical composition and an assessment of the biological activity are required to establish the quality of propolis.

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Phenolic composition, antioxidant, antibacterial, larvacidal against Culex pipiens, and cytotoxic activities of Hyacinthella lineata steudel extracts

International Journal of Food Properties ◽

10.1080/10942912.2016.1236271 ◽

2017 ◽

Vol 20 (10) ◽

pp. 2276-2285 ◽

Cited By ~ 6

Author(s):

Cigdem Aydın ◽

Ramazan Mammadov

Keyword(s):

Culex Pipiens ◽

Cytotoxic Activities ◽

Phenolic Composition

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Phenolic Profile, Antioxidant and Anti-Proliferative Activities of Methanolic Extracts from Asclepias linaria Cav. Leaves

Molecules ◽

10.3390/molecules25010054 ◽

2019 ◽

Vol 25 (1) ◽

pp. 54

Author(s):

José Alejandro Sánchez-Gutiérrez ◽

Dafné Moreno-Lorenzana ◽

Dioselina Álvarez-Bernal ◽

Jacobo Rodríguez-Campos ◽

José Roberto Medina-Medrano

Keyword(s):

Antioxidant Capacity ◽

Total Antioxidant Capacity ◽

Ultra Performance Liquid Chromatography ◽

Total Phenolic ◽

Cytotoxic Activities ◽

Scavenging Activity ◽

Phenolic Composition ◽

Alternative Source ◽

Methanolic Extracts ◽

Total Antioxidant

Asclepias linaria Cav. (Apocynaceae) is a shrubby plant endemic of Mexico which has been used in traditional medicine. However, the bioactive potential of this plant remains unexplored. In this study, the phenolic composition, antioxidant, and cytotoxic activities of A. linaria leaves were determined. In order to estimate the phenolic composition of the leaves, the total phenolic, flavonoid, and condensed tannins contents were determined. Furthermore, the antioxidant activity was measured by the scavenging activity of the 2,2-diphenyl-1-picrylhydrazyl (DPPH•) and 2,2′-azino-bis[3-ethylbenzothiazoline-6-sulphonic acid] (ABTS•+) radicals and the total antioxidant capacity. The phenolic compounds identified in the A. linaria leaves by ultra-performance liquid chromatography coupled to mass spectrometry (UPLC-MS) include phenolic acids, such as p-coumaric and ferulic acid, as well as flavonoids, such as rutin and quercetin. The leaves’ extracts of A. linaria showed a high scavenging activity of DPPH• and ABTS•+ radicals (IC50 0.12 ± 0.001 and 0.51 ± 0.003 µg/mL, respectively), high total antioxidant capacity values (99.77 ± 4.32 mg of ascorbic acid equivalents/g of dry tissue), and had a cytotoxic effect against K562 and HL60 hematologic neoplasia cells lines, but no toxicity towards the normal mononuclear cell line was observed. These results highlight the potential of A. linaria and could be considered as a possible alternative source of anticancer compounds.

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Comparative Studies on Phenolic Composition, Antioxidant, Wound Healing and Cytotoxic Activities of Selected Achillea L. Species Growing in Turkey

Molecules ◽

10.3390/molecules201017976 ◽

2015 ◽

Vol 20 (10) ◽

pp. 17976-18000 ◽

Cited By ~ 35

Author(s):

Osman Agar ◽

Miris Dikmen ◽

Nilgun Ozturk ◽

Mustafa Yilmaz ◽

Hamdi Temel ◽

...

Keyword(s):

Wound Healing ◽

Comparative Studies ◽

Cytotoxic Activities ◽

Phenolic Composition

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Antioxidant, Antibacterial, Cytotoxic, and Anti-Inflammatory Potential of the Leaves ofSolanum lycocarpumA. St. Hil. (Solanaceae)

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2015/315987 ◽

2015 ◽

Vol 2015 ◽

pp. 1-8 ◽

Cited By ~ 3

Author(s):

Guilherme Augusto Ferreira da Costa ◽

Melissa Grazielle Morais ◽

Aline Aparecida Saldanha ◽

Izabela Caputo Assis Silva ◽

Álan Alex Aleixo ◽

...

Keyword(s):

Ethyl Acetate ◽

High Performance ◽

Ethanol Extract ◽

Ethyl Acetate Fraction ◽

Cytotoxic Activities ◽

Phenolic Composition ◽

Cytotoxic Potential ◽

Phenolic Constituents ◽

Anti Inflammatory ◽

Later Phase

Ethanol extract and fractions obtained from leaves ofSolanum lycocarpumwere examined in order to determine their phenolic composition, antioxidant, antibacterial, anti-inflammatory, and cytotoxic potential. High performance liquid chromatography coupled with DAD analysis indicated that the flavonoids apigenin and kaempferol were the main phenolic compounds present in dichloromethane and ethyl acetate fractions, respectively. The antioxidant activity was significantly more pronounced for dichloromethane, ethyl acetate, and hydroethanol fractions than that of the commercial antioxidant 2,6-di-tert-butyl-4-methylphenol. The hexane and dichloromethane fractions were more active against the tested bacteria. The hydroethanol fraction exhibited significant anti-inflammatory activity at the dose of 75 and 150 mg/kg in the later phase of inflammation. However, the antiedematogenic effect of the higher dose of the ethyl acetate fraction (150 mg/kg) was more pronounced. The ethyl acetate fraction also presented a less cytotoxic effect than the ethanol extract and other fractions. These activities found inS. lycocarpumleaves can be attributed, at least in part, to the presence of phenolic constituents such as flavonoids. This work provided the knowledge of phenolic composition in the extract and fractions and the antioxidant, antibacterial, anti-inflammatory, and cytotoxic activities of leaves ofS. lycocarpum.

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