Statistical Analysis of Protein Microarray Data: A Case Study in Type 1 Diabetes Research

2015 ◽  
Vol 08 (02) ◽  
Author(s):  
Le TT An Anna Pursiheimo
Keyword(s):  
Type 1 Diabetes ◽  
Statistical Analysis ◽  
Microarray Data ◽  
Protein Microarray ◽  
Diabetes Research

209-OR: ADA Presidents' Select Abstract: Type 1 Diabetes and the Developing Brain—A Longitudinal Study of Brain Growth by the Diabetes Research in Children Network (DirecNet)

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 209-OR ◽  
Author(s):  
ANA MARIA ARBELAEZ ◽  
STEFANI O’DONOGHUE ◽  
NELLY MAURAS ◽  
BRUCE A. BUCKINGHAM ◽  
NEIL H. WHITE ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Longitudinal Study ◽  
Developing Brain ◽  
Diabetes Research ◽  
Brain Growth ◽  
Select Abstract

scholarly journals Luminex and Other Multiplex High Throughput Technologies for the Identification of, and Host Response to, Environmental Triggers of Type 1 Diabetes

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Sharad Purohit ◽  
Ashok Sharma ◽  
Jin-Xiong She
Keyword(s):  
Type 1 Diabetes ◽  
High Throughput ◽  
Host Response ◽  
Environmental Pollutants ◽  
Silent Period ◽  
Dietary Factors ◽  
Systematic Evaluation ◽  
Complex Nature ◽  
Diabetes Research

Complex interactions between a series of environmental factors and genes result in progression to clinical type 1 diabetes in genetically susceptible individuals. Despite several decades of research in the area, these interactions remain poorly understood. Several studies have yielded associations of certain foods, infections, and immunizations with the onset and progression of diabetes autoimmunity, but most findings are still inconclusive. Environmental triggers are difficult to identify mainly due to (i) large number and complex nature of environmental exposures, including bacteria, viruses, dietary factors, and environmental pollutants, (ii) reliance on low throughput technology, (iii) less efforts in quantifying host response, (iv) long silent period between the exposure and clinical onset of T1D which may lead to loss of the exposure fingerprints, and (v) limited sample sets. Recent development in multiplex technologies has enabled systematic evaluation of different classes of molecules or macroparticles in a high throughput manner. However, the use of multiplex assays in type 1 diabetes research is limited to cytokine assays. In this review, we will discuss the potential use of multiplex high throughput technologies in identification of environmental triggers and host response in type 1 diabetes.

scholarly journals Approaches in type 1 diabetes research: A status report

2009 ◽  
Vol 29 (2) ◽  
pp. 85 ◽  
Author(s):  
VR Rao ◽  
Oindrila Raha ◽  
Subhankar Chowdhury ◽  
Samir Dasgupta ◽  
P Raychaudhuri ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Status Report ◽  
Diabetes Research
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