Identification of a Pathway-Based 5-Gene Expression Signature for Predicting Outcomes in Gastric Cancer

2018 ◽  
Vol 11 (09) ◽  
Author(s):  
Nikolay Alabi ◽  
Dropen Sheka ◽  
Mehul Gupta ◽  
Sunand Kannappan
Keyword(s):  
Gene Expression ◽  
Gastric Cancer ◽  
Gene Expression Signature ◽  
Expression Signature

scholarly journals Combining gene expression signature with clinical features for survival stratification of gastric cancer

Genomics ◽  
2021 ◽  
Author(s):  
Qiang Sun ◽  
Dongyang Guo ◽  
Shuang Li ◽  
Yanjun Xu ◽  
Mingchun Jiang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gastric Cancer ◽  
Clinical Features ◽  
Gene Expression Signature ◽  
Expression Signature

Molecular gene expression signature patterns for gastric cancer diagnosis

2007 ◽  
Vol 31 (4) ◽  
pp. 275-287 ◽  
Author(s):  
Yee Leng Yap ◽  
Xue Wu Zhang ◽  
David Smith ◽  
Richie Soong ◽  
Jeffrey Hill
Keyword(s):  
Gene Expression ◽  
Gastric Cancer ◽  
Cancer Diagnosis ◽  
Gene Expression Signature ◽  
Expression Signature

scholarly journals Gene Expression Signature–Based Prognostic Risk Score in Gastric Cancer

2011 ◽  
Vol 17 (7) ◽  
pp. 1850-1857 ◽  
Author(s):  
Jae Yong Cho ◽  
Jae Yun Lim ◽  
Jae Ho Cheong ◽  
Yun-Yong Park ◽  
Se-Lyun Yoon ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gastric Cancer ◽  
Risk Score ◽  
Gene Expression Signature ◽  
Expression Signature

scholarly journals Gene Expression Signature Analysis Identifies Vorinostat as a Candidate Therapy for Gastric Cancer

PLoS ONE ◽  
2011 ◽  
Vol 6 (9) ◽  
pp. e24662 ◽  
Author(s):  
Sofie Claerhout ◽  
Jae Yun Lim ◽  
Woonyoung Choi ◽  
Yun-Yong Park ◽  
KyoungHyun Kim ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gastric Cancer ◽  
Gene Expression Signature ◽  
Signature Analysis ◽  
Expression Signature

Association of YAP1 activation with poor patient prognosis and effect on chemoresistance in gastric cancer.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. 4113-4113
Author(s):  
Sung Sook Lee ◽  
Sang Cheul Oh ◽  
Woojin Jeong ◽  
Sang Ho Lee ◽  
Sang-Bae Kim ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gastric Cancer ◽  
Adjuvant Chemotherapy ◽  
Therapeutic Target ◽  
Notch Pathway ◽  
Gene Expression Signature ◽  
Expression Signature ◽  
Tumor Subtypes ◽  
Attractive Therapeutic Target ◽  
Patient Prognosis

4113 Background: Clinical heterogeneity in gastric cancer is likely due to biological differences among patients. Molecular subtypes and their associated biomarkers need to be established to improve treatment of this disease. We aimed to uncover subgroups of gastric cancer that have distinct biological characteristics associated with clinical outcome and to identify potential best treatments or therapeutic targets for each subgroup. Methods: We analyzed gene expression profiling data from gastric cancer cell lines and 267 patients with gastric cancer to uncover tumor subtypes and identify a gene expression signature associated with prognosis and response to adjuvant chemotherapy. The association of the signature with prognosis was validated in an independent cohort of 200 patients, and its association with response to adjuvant therapy was validated by cell culture experiments. Results: We identified an expression signature of 88 genes that specifically reflected activation of the oncogene YAP1. Compared with patients without this signature, patients with the YAP1 signature had significantly poorer prognosis. In multivariate analysis, the signature was the strongest indicator of overall survival among all demographic and clinical variables examined together (hazard ratio, 2.1; 95% confidence interval, 1.3-3.3;P = .002). Activation of YAP1 was significantly associated with resistance to adjuvant chemotherapy. We also demonstrated that the Notch pathway is a potential therapeutic target for overcoming chemoresistance mediated by YAP1. Conclusions: Activation of the oncogene YAP1 is significantly associated with poorer survival of patients with gastric cancer and induces chemoresistance to this disease. Therefore, YAP1 may be highly attractive therapeutic target for patients with gastric cancer resistant to standard chemotherapy.

Systematic analysis of multigene predictors in gastric cancer exploiting gene expression signature

2018 ◽  
Vol 120 (5) ◽  
pp. 8069-8077 ◽  
Author(s):  
Kuankuan Ai ◽  
Yanli Jia ◽  
Jin Li ◽  
Chong Wang ◽  
Yan Wang
Keyword(s):  
Gene Expression ◽  
Gastric Cancer ◽  
Gene Expression Signature ◽  
Systematic Analysis ◽  
Expression Signature

Integrated immune gene expression signature and molecular classification in gastric cancer: New insights

2020 ◽  
Vol 108 (2) ◽  
pp. 633-646 ◽  
Author(s):  
Maria Grazia Refolo ◽  
Claudio Lotesoriere ◽  
Caterina Messa ◽  
Maria Gabriella Caruso ◽  
Rosalba D'Alessandro
Keyword(s):  
Gene Expression ◽  
Gastric Cancer ◽  
Gene Expression Signature ◽  
Molecular Classification ◽  
Immune Gene ◽  
Expression Signature ◽  
Immune Gene Expression
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