scholarly journals Comparative Modeling of Viral Protein R (VpR) from Human Immunodeficiency Virus 1 (HIV 1)

2008 ◽  
Vol 01 (02) ◽  
pp. 073-076 ◽  
Author(s):  
Seenivasagan Renganathan ◽  
Kasimani Renganathan ◽  
Marimuthu Parthiban ◽  
Kalidoss Ramamoorthy ◽  
Shanmughavel Piramanayagam
Keyword(s):  
Human Immunodeficiency Virus ◽  
Viral Protein ◽  
Comparative Modeling ◽  
Viral Protein R ◽  
Immunodeficiency Virus ◽  
Hiv 1 ◽  
Human Immunodeficiency Virus 1

scholarly journals Multifunctional viral protein R of human immunodeficiency virus-1 as a potential drug target

2014 ◽  
Vol 3 (4) ◽  
pp. 104
Author(s):  
Vivek Darapaneni
Keyword(s):  
Human Immunodeficiency Virus ◽  
Binding Sites ◽  
Viral Protein ◽  
Drug Target ◽  
Amino Acid Sequences ◽  
The Novel ◽  
Conservation Analysis ◽  
Viral Protein R ◽  
Immunodeficiency Virus ◽  
Human Immunodeficiency Virus 1

<p>The viral protein R (Vpr) plays a pivotal role in the infectious lifecycle of human immunodeficiency virus-1. The objective of this study is to find the degree of conservation of Vpr and to detect conserved binding sites, which might be used as target sites for potential anti-Vpr drugs. The conservation analysis was based on 5301 amino acid sequences identified novel conserved and highly conserved sites.  The novel conserved sites which have been identified are: Leu42, Gly43 and Val57; Arg73 and Cys76; Glu24, His33, Cys76 and Ser79.<strong> </strong>The outcome of this study provide the foundation for developing anti-Vpr drugs which have abridged potential to induce drug resistance through mutations.</p>

scholarly journals APOBEC3H haplotypes and HIV-1 pro-viral vif DNA sequence diversity in early untreated human immunodeficiency virus–1 infection

2011 ◽  
Vol 72 (3) ◽  
pp. 207-212 ◽  
Author(s):  
P.A. Gourraud ◽  
A. Karaouni ◽  
J.M. Woo ◽  
T. Schmidt ◽  
J.R. Oksenberg ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Dna Sequence ◽  
Sequence Diversity ◽  
Immunodeficiency Virus ◽  
Hiv 1 ◽  
Human Immunodeficiency Virus 1

scholarly journals Human immunodeficiency virus 1. Predominance of a group-specific neutralizing epitope that persists despite genetic variation.

1989 ◽  
Vol 170 (5) ◽  
pp. 1681-1695 ◽  
Author(s):  
I Berkower ◽  
G E Smith ◽  
C Giri ◽  
D Murphy
Keyword(s):  
Genetic Diversity ◽  
Human Immunodeficiency Virus ◽  
Neutralizing Antibodies ◽  
Neutralizing Epitope ◽  
Vaccine Strategy ◽  
Disease Pathogenesis ◽  
Immunodeficiency Virus ◽  
High Degree ◽  
Hiv 1 ◽  
Human Immunodeficiency Virus 1

HIV-1 is known to show a high degree of genetic diversity, which may have major implications for disease pathogenesis and prevention. If every divergent isolate represented a distinct serotype, then effective vaccination might be impossible. However, using a sensitive new plaque-forming assay for HIV-1, we have found that most infected patients make neutralizing antibodies, predominantly to a group-specific epitope shared among three highly divergent isolates. This epitope persists among divergent isolates and rarely mutates, despite the rapid overall mutation rate of HIV-1, suggesting that it may participate in an essential viral function. These findings, plus the rarity of reinfections among these patients, suggest that HIV-1 may be more susceptible to a vaccine strategy based on a group-specific neutralizing epitope than was previously suspected.

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