scholarly journals HLA-DRB1* Allele Frequencies in Pediatric, Adolescent and Adult-Onset Multiple Sclerosis Patients, in a Hellenic Sample. Evidence for New and Established Associations

2013 ◽  
Vol 01 (01) ◽  
Author(s):  
Maria C Anagnostouli ◽  
Argyro Manouseli
Keyword(s):  
Multiple Sclerosis ◽  
Allele Frequencies ◽  
Adult Onset ◽  
Drb1 Allele ◽  
Multiple Sclerosis Patients

scholarly journals HLA allele frequencies in Iranian opticospinal multiple sclerosis patients<br>——HLA in Opticospinal MS

2011 ◽  
Vol 04 (07) ◽  
pp. 511-515
Author(s):  
Hossein Kalanie ◽  
Malihe Kamgooyan ◽  
Yadollah Kholghie ◽  
Ali Amini Harandi ◽  
Zahra Hosseinzadeh
Keyword(s):  
Multiple Sclerosis ◽  
Allele Frequencies ◽  
Multiple Sclerosis Patients

Pediatric Multiple Sclerosis

2012 ◽  
Vol 27 (11) ◽  
pp. 1378-1383 ◽  
Author(s):  
Sandra Bigi ◽  
Brenda Banwell
Keyword(s):  
Multiple Sclerosis ◽  
Transverse Myelitis ◽  
Acute Disseminated Encephalomyelitis ◽  
Neurological Deficits ◽  
Disease Course ◽  
Adult Onset ◽  
Permanent Disability ◽  
Pediatric Multiple Sclerosis ◽  
Multiple Sclerosis Patients ◽  
Patients Experience

Pediatric multiple sclerosis has been increasingly recognized in the past 10 to 15 years; 3% to 5% of all multiple sclerosis patients experience their first attack in childhood. Childhood multiple sclerosis has a relapsing-remitting disease course. The first attack, or “acquired demyelinating syndrome,” consists of optic neuritis, transverse myelitis, acute disseminated encephalomyelitis, and monofocal or polyfocal neurological deficits. The diagnosis of multiple sclerosis necessitates the clinical or magnetic resonance imaging confirmation of dissemination in space and time and exclusion of other disorders. The morbidity of childhood multiple sclerosis is significant; within the first 2 years from onset, 30% of children have significant cognitive impairment, 50% show signs of depression, and 75% are fatigued. The relapse rate in children with multiple sclerosis is higher than in adult-onset disease. Following acute treatment, recovery after the first attacks is usually excellent, but patients with childhood-onset multiple sclerosis reach permanent disability or enter the secondary progressive disease course 10 years younger than patients with adult-onset multiple sclerosis.

Comparative clinical characteristics of early- and adult-onset multiple sclerosis patients with seizures

2013 ◽  
Vol 113 (4) ◽  
pp. 421-426 ◽  
Author(s):  
Hacer Durmus ◽  
Murat Kurtuncu ◽  
Erdem Tuzun ◽  
Munevver Pehlivan ◽  
Gulsen Akman-Demir ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Clinical Characteristics ◽  
Adult Onset ◽  
Multiple Sclerosis Patients

scholarly journals Early Onset Multiple Sclerosis Has Worse Prognosis Than Adult Onset Multiple Sclerosis Based on Cognition and Magnetic Resonance Imaging

2012 ◽  
Vol 2012 ◽  
pp. 1-5
Author(s):  
Serkan Ozakbas ◽  
Derya Kaya ◽  
Egemen Idiman
Keyword(s):  
Magnetic Resonance Imaging ◽  
Multiple Sclerosis ◽  
Cognitive Impairment ◽  
Magnetic Resonance ◽  
Early Onset ◽  
Adult Onset ◽  
Resonance Imaging ◽  
Significant Difference ◽  
Multiple Sclerosis Patients ◽  
Worse Prognosis

Objectives. In the present study, we aimed to compare the childhood and adult onset multiple sclerosis patients prospectively in their adulthood on the basis of clinical and magnetic resonance imaging (MRI) findings and cognitive impairment, which have not been performed before.Patients and Methods. Forty-six patients in whom the disease onset occurred before 16 years of age were included in the present study. Study subjects were compared with 64 randomly included adult onset patients.Results. Mean disease duration, clinical course, and female to male ratio did not differ in the groups. Cerebellar/brainstem and spinal involvement at onset were significantly higher in EOMS than in AOMS. Difference in MSFC between baseline and at the end of the 5th year was significantly worse in EOMS population (). The most significant difference was found in Paced Auditory Serial Addition Test (PASAT) (). Differences between baseline and at the end of the 5th year on the basis of T1 hypointense lesions were significantly higher in early onset MS than in adult onset MS patients ().Conclusions. Early onset MS seems to have worse prognosis than that of adult onset MS on the basis of clinical manifestation, cognitive impairment, and MRI parameters.

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