Bioequivalence of Alprazolam Sublingual Tablet Formulation and Alprazolam Immediate Release Tablet in Healthy Volunteers

2013 ◽  
Vol 05 (04) ◽  
Author(s):  
Bharat Damle
Keyword(s):  
Healthy Volunteers ◽  
Immediate Release ◽  
Tablet Formulation ◽  
Sublingual Tablet ◽  
Release Tablet

scholarly journals Influence of immediate release tablet formulation on dissolution profile of paracetamol

2018 ◽  
Vol 5 (3) ◽  
pp. 705-714
Author(s):  
Nemanja Todorović ◽  
Svetlana Goločorbin-Kon ◽  
Kristina Kermeci ◽  
Jelena Jovičić-Bata ◽  
Nebojša Pavlović ◽  
...  
Keyword(s):  
Immediate Release ◽  
Tablet Formulation ◽  
Dissolution Profile ◽  
Release Tablet

scholarly journals Immediate release tablet formulation of varenicline salicylate and comparative pharmacokinetic study in human volunteers

2018 ◽  
Vol Volume 12 ◽  
pp. 3377-3392
Author(s):  
Seong Shin Kwak ◽  
Eun Seok Lee ◽  
Ho Yub Yoon ◽  
Chang Hyun Kim ◽  
Yoon Tae Goo ◽  
...  
Keyword(s):  
Pharmacokinetic Study ◽  
Immediate Release ◽  
Tablet Formulation ◽  
Comparative Pharmacokinetic ◽  
Human Volunteers ◽  
Release Tablet

Relative bioavailability of diclofenac potassium from softgel capsule versus powder for oral solution and immediate-release tablet formulation

2015 ◽  
Vol 5 (1) ◽  
pp. 76-82 ◽  
Author(s):  
Girish Bende ◽  
Shibadas Biswal ◽  
Prafulla Bhad ◽  
Yuming Chen ◽  
Atish Salunke ◽  
...  
Keyword(s):  
Immediate Release ◽  
Relative Bioavailability ◽  
Oral Solution ◽  
Tablet Formulation ◽  
Release Tablet

scholarly journals Development and In Vitro-In Vivo Evaluation of a Novel Sustained-Release Loxoprofen Pellet with Double Coating Layer

Pharmaceutics ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 260 ◽  
Author(s):  
Dongwei Wan ◽  
Min Zhao ◽  
Jingjing Zhang ◽  
Libiao Luan
Keyword(s):  
Citric Acid ◽  
Drug Release ◽  
Sustained Release ◽  
Release Rate ◽  
Diffusion Rate ◽  
Immediate Release ◽  
Pharmacokinetic Studies ◽  
Release Tablet

This study aimed to develop a novel sustained release pellet of loxoprofen sodium (LXP) by coating a dissolution-rate controlling sub-layer containing hydroxypropyl methyl cellulose (HPMC) and citric acid, and a second diffusion-rate controlling layer containing aqueous dispersion of ethyl cellulose (ADEC) on the surface of a LXP conventional pellet, and to compare its performance in vivo with an immediate release tablet (Loxinon®). A three-level, three-factor Box-Behnken design and the response surface model (RSM) were used to investigate and optimize the effects of the citric acid content in the sub-layer, the sub-layer coating level, and the outer ADEC coating level on the in vitro release profiles of LXP sustained release pellets. The pharmacokinetic studies of the optimal sustained release pellets were performed in fasted beagle dogs using an immediate release tablet as a reference. The results illustrated that both the citric acid (CA) and ADEC as the dissolution- and diffusion-rate controlling materials significantly decreased the drug release rate. The optimal formulation showed a pH-independent drug release in media at pH above 4.5 and a slightly slow release in acid medium. The pharmacokinetic studies revealed that a more stable and prolonged plasma drug concentration profile of the optimal pellets was achieved, with a relative bioavaibility of 87.16% compared with the conventional tablets. This article provided a novel concept of two-step control of the release rate of LXP, which showed a sustained release both in vitro and in vivo.

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