scholarly journals A new bound for smooth spline spaces

2020 ◽  
Vol 4 (4) ◽  
pp. 359-367
Author(s):  
Hal Schenck ◽  
Mike Stillman ◽  
Beihui Yuan
Keyword(s):  
2005 ◽  
Vol 38 (1) ◽  
pp. 193-198 ◽  
Author(s):  
Kevin Cowtan

A method for the weighting of structure factors from an incomplete and inaccurate model is described which relies on the fitting of smooth spline functions of resolution. The use of smooth spline functions avoids the problems of discontinuities introduced when performing calculations in resolution shells. The complexity of the functions to be fit may be varied by changing the number of spline parameters. This approach is used to investigate the stability of the problem when data are limited.


2018 ◽  
Vol 38 (8) ◽  
pp. 0815020
Author(s):  
赵琪涵 Zhao Qihan ◽  
王永红 Wang Yonghong ◽  
高新亚 Gao Xinya ◽  
孙方圆 Sun Fangyuan ◽  
闫佩正 Yan Peizheng ◽  
...  

2021 ◽  
Author(s):  
Lifeng Chen ◽  
Jun Chen ◽  
Yi Ren ◽  
Ronghui Du ◽  
Na Li ◽  
...  

Abstract BackgroundSerological tests for anti-2019-nCoV antibodies have been developed, however, validation with clinical samples was insufficient and mixed. MethodsA total of 197 patients with COVID-19 hospitalized in the Wuhan Pulmonary Hospital and 114 healthy people were enrolled in this study. The IgM/IgG was measured by chemiluminescence detection kit and the performance of IgM/IgG was assessed through diagnostic test. A smooth spline function was used to fit a possible dynamic changes of antibody content.ResultsThe sensitivity and specificity to diagnose COVID-19 were 96.95% and 92.98% for IgG, and 65.99% and 98.25% for IgM, respectively. The period with the highest IgM positive rate (93.75%) was 11 to 13 days after the onset, while the IgG positive rate was almost 100% in the patients whose serum was collected 7 days after onset. Small differences were found in IgM content among mild/regular, severe and critical patients. IgG content in critical patients were highest in the 2-week post-symptom onset group, while the IgG in the severe patients were highest in the 15-28 days and more than 28 days post-symptom onset.ConclusionsSerological testing performed well in the diagnosis for COVID-19, and the positive rate and variance of IgG are higher than those of IgM.


2021 ◽  
Author(s):  
Qian Song ◽  
Jinghui Qiu ◽  
Pengcheng Wang ◽  
Nannan Wang
Keyword(s):  

2010 ◽  
Vol 27 (1) ◽  
pp. 96-105 ◽  
Author(s):  
Jörg Peters ◽  
Jianhua Fan

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