Rapid-onset of severe tigecycline-induced coagulopathy in drug reaction with eosinophilia and systemic symptom syndrome

2016 ◽  
Vol 4 (1) ◽  
pp. 74 ◽  
Author(s):  
Yeong Jin Jeong ◽  
Byeongzu Ghanh ◽  
Ji Wan Lee ◽  
Jinoh Park ◽  
Tae-Bum Kim ◽  
...  
Keyword(s):  
Drug Reaction ◽  
Rapid Onset ◽  
Systemic Symptom

The association between HLA-B*15:02 and phenytoin-induced severe cutaneous adverse reactions: a meta-analysis

2021 ◽  
Author(s):  
Thanh Huong Phung ◽  
Khanh Ngoc Cong Duong ◽  
Mac Ardy Junio Gloria ◽  
Thien Khac Nguyen
Keyword(s):  
Drug Reaction ◽  
Adverse Reactions ◽  
Meta Analysis ◽  
Stevens Johnson Syndrome ◽  
Random Effects Model ◽  
Systemic Symptom ◽  
Anticonvulsant Agent ◽  
Johnson Syndrome ◽  
Severe Cutaneous Adverse Reactions ◽  
Cutaneous Adverse Reactions

Aim: Phenytoin (PHT) is a common anticonvulsant agent known for inducing severe cutaneous adverse reactions (SCARs). HLA-B*15:02 as a risk factor of PHT-induced SCARs was reported in numerous studies with inconsistent results. This meta-analysis aimed to establish pooling evidence of this association. Materials & methods: Pooled odds ratios (ORs) with 95% CIs were estimated using a random-effects model. Results: A total of 11 studies on 1389 patients, were included for the analyses. There was a significant association between HLA-B*15:02 and PHT-induced SCAR (pooled OR = 2.29, 95% CI: 1.25–4.19, p = 0.008). Furthermore, there was a significant association regarding Stevens–Johnson syndrome/toxic epidermal necrolysis (OR = 3.63, 95% CI: 2.15–6.13, p < 0.001) but no association regarding drug reaction with eosinophilia and systemic symptom. Conclusion: The results supported the recommendations of HLA-B*15:02 screening before treatment with PHT.

scholarly journals A Case of the Drug Reaction with Eosinophilia and Systemic Symptom (DRESS) Following Isoniazid Treatment

2015 ◽  
Vol 78 (1) ◽  
pp. 27 ◽  
Author(s):  
Jin-Yong Lee ◽  
Yun-Jae Seol ◽  
Dong-Woo Shin ◽  
Dae-Young Kim ◽  
Hong-Woo Chun ◽  
...  
Keyword(s):  
Drug Reaction ◽  
Systemic Symptom

scholarly journals Drug Reaction With Eosinophilia and Systemic Symptom (DRESS) pada Tuberkulosis Payudara dalam Pengobatan

2020 ◽  
Vol 8 (4) ◽  
Author(s):  
Rudi Erwin Kurniawan ◽  
Raveinal Raveinal
Keyword(s):  
Drug Reaction ◽  
Systemic Symptom

Drug Reaction With Eosinophilia and Systemic Symptom (DRESS) atau sindroma DRESS merupakan suatu reaksi idiosinkratik yang terjadi setelah pemberian obat dalam dosis terapi yang ditandai dengan manifestasi klinis berupa adanya erupsi eritematosa, demam, kelainan hematologi terutama adanya eosinofilia dan adanya keterlibatan organ dalam seperti hepatitis, nefritis, limfadenopati, pneumonitis dan miokarditis. Sindroma DRESS sering disebabkan oleh obat seperti trimetropim, allopurinol, metronidazol, dapson dan abacavir. Penyaki ini juga dapat terjadi akibat reaksi silang obat, seperti obat anti konvulsan (carbamazepin, fenitoin, fenobarbital) dan obat anti inflamasi non steroid (piroksikam). Dilaporkan pasien wanita 34 tahun dengan keluhan utama kuning pada mata yang disertai bercak kemerahan pada wajah, badan, lengan dan tungkai. Manifestasi klinis muncul setelah pasien mengkonsumsi obat anti tuberkulosis selama 1,5 bulan. Pada pemeriksaan penunjang yang khas tampak eosinophilia dengan limfositik atipik dan keterlibatan organ dalam berupa hepatitis setelah menyingkirkan penyebab lain dari hepatitis. Setelah dilakukan penghentian obat anti tuberkulosis selama 2 mingga tampak perbaikan yang signifikan pada manifestasi kulit dan hematologi. Pasien kemudian dilakukan tes provokasi untuk menentukan obat yang menjadi penyebab terjadinya sindroma DRESS.

scholarly journals Concomitant Drug Reaction with Eosinophilia and Systemic Symptom Syndrome from Ethambutol and Autoimmune Hepatitis from Isoniazid

2016 ◽  
Vol 67 (5) ◽  
pp. 267 ◽  
Author(s):  
Joon Hyuk Choi ◽  
Nae-Yun Heo ◽  
Seung Ha Park ◽  
Chan Sun Park ◽  
Kyeong Min Jo ◽  
...  
Keyword(s):  
Drug Reaction ◽  
Autoimmune Hepatitis ◽  
Systemic Symptom ◽  
Concomitant Drug

Checkpoint inhibitor-associated drug reaction with eosinophilia and systemic symptom syndrome

2017 ◽  
Vol 27 (3) ◽  
pp. 271-273 ◽  
Author(s):  
Sayeef Mirza ◽  
Ebone’ Hill ◽  
Steven P. Ludlow ◽  
Sowmya Nanjappa
Keyword(s):  
Drug Reaction ◽  
Checkpoint Inhibitor ◽  
Systemic Symptom

scholarly journals Drug reaction with eosinophilia and systemic symptom induced by carbamazepine: a case report

2019 ◽  
Vol 8 (5) ◽  
pp. 1115
Author(s):  
Rahul R. Damor ◽  
Amita R. Kubavat ◽  
Kiran G. Piparva
Keyword(s):  
Drug Reaction ◽  
Case Report ◽  
Antiepileptic Drugs ◽  
Drug Exposure ◽  
Latency Period ◽  
Systemic Symptom ◽  
Dress Syndrome ◽  
Period 2 ◽  
Life Threatening ◽  
Systemic Symptoms

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a severe, potentially life-threatening acute adverse drug reaction (ADR), typically characterized by a long latency period (2-6 weeks to 3 months) from drug exposure. DRESS syndrome is defined by the presence of fever, cutaneous eruption, lymphadenopathy, systemic or asymptomatic internal organ involvement (e.g. Hepatitis, carditis, interstitial nephritis, interstitial pneumonitis, etc.) and haematological abnormalities, mainly leucocytosis, eosinophilia and sometimes atypical lymphocytosis. There are around 50 culprit drugs which cause DRESS syndrome e.g. carbamazepine, phenytoin, allopurinol, sulfa derivatives, antidepressants, antiepileptics, non-steroidal anti-inflammatory drugs and antimicrobials. The incidence of DRESS syndrome has been estimated to be between 1 in 1,000 and 1 in 10,000 drug exposures. There are many reported cases of DRESS syndrome due to carbamazepine, phenytoin, vancomycin, levitiracitam, ceftriaxone etc. Author presented a case of DRESS syndrome by carbamazepin. RegiSCAR and Japanese consensus group have developed specific criteria for making the diagnosis of DRESS syndrome. The patient described here met the majority of criteria according to RegiSCAR scoring guidelines for a diagnosis of DRESS syndrome induced by carbamazepine. As per RegiSCAR diagnostic criteria author had concluded that this was a “Definite” case of DRESS (Drug Reaction with Eosinophilia and Systemic Symptom) syndrome induced by carbamazepine. Carbamazepine is most common broad-spectrum antiepileptic drugs so, this case report will raises awareness among physician to suspect DRESS syndrome in patients who present unusual complaints and skin findings after starting antiepileptic drugs.

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