Simulation for Particle Size Design and Scale-up of Grinding-Classification of Silica Sand in a Ball Mill Application

2012 ◽  
Vol 49 (3) ◽  
pp. 210-215
Author(s):  
Norihiko Yagi ◽  
Yoshihiro Satoh ◽  
Yasutake Mori
Keyword(s):  
Particle Size ◽  
Ball Mill ◽  
Scale Up ◽  
Silica Sand

Azithromycin nanosuspension preparation using evaporative precipitation into aqueous solution (EPAS) method and its comparative dissolution study

2020 ◽  
Vol 17 ◽  
Author(s):  
Mohammad Hossain Shariare ◽  
Tonmoy Kumar Mondal ◽  
Hani Alothaid ◽  
Md. Didaruzzaman Sohel ◽  
MD Wadud ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Particle Size ◽  
Dissolution Rate ◽  
Average Particle Size ◽  
Scale Up ◽  
Average Particle ◽  
Total Drug ◽  
Residual Solvent ◽  
Dissolution Study ◽  
Drug Content

Aim: EPAS (evaporative precipitation into aqueous solution) was used in the current studies to prepare azithromycin nanosuspensions and investigate the physicochemical characteristics for the nanosuspension batches with the aim of enhancing the dissolution rate of the nanopreparation to improve bioavailability. Methods: EPAS method used in this study for preparing azithromycin nanosuspension was achieved through developing an in-house instrumentation method. Particle size distribution was measured using Zetasizer Nano S without sample dilution. Dissolved azithromycin nanosuspensions were also compared with raw azithromycin powder and commercially available products. Total drug content of nanosuspension batches were measured using an Ultra-Performance Liquid Chromatography (UPLC) system with Photodiode Array (PDA) detector while residual solvent was measured using gas chromatography (GC). Results: The average particle size of azithromycin nanosuspension was 447.2 nm and total drug content was measured to be 97.81% upon recovery. Dissolution study data showed significant increase in dissolution rate for nanosuspension batch when compared to raw azithromycin and commercial version (microsuspension). The residual solvent found for azithromycin nanosuspension is 0.000098023 mg/ mL or 98.023 ppb. Conclusion: EPAS was successfully used to prepare azithromycin nanoparticles that exhibited significantly enhanced dissolution rate. Further studies are required to scale up the process and determine long term stability of the nanoparticles.

Application of Microfluidics in Process Intensification

2018 ◽  
Vol 16 (12) ◽  
Author(s):  
Harrson S. Santana ◽  
Mariana G. M. Lopes ◽  
João L. Silva ◽  
Osvaldir P. Taranto
Keyword(s):  
Scale Up ◽  
Production Capacity ◽  
Process Intensification ◽  
Plant Size ◽  
Chemical Plant ◽  
Sustainable Operations ◽  
Production Techniques ◽  
Equipment Size ◽  
System Miniaturization

Abstract Is it possible to miniaturize a chemical plant? Some strategies, such as the process intensification, sustain that the advancements in equipment and production techniques could substantially decrease the equipment size/production capacity ratio, energy consumption and waste generation, resulting in more economic and sustainable operations and consequently reducing the chemical plant size. However, large reductions of equipment volume represent a major challenge for the conventional technologies. In this context, Microfluidics represents a promising technology in the field of system miniaturization. Accordingly, the present research evaluated the concept of process intensification and its relationship with Microfluidics. Initially, the definition and the classification of process intensification were described, following by the explanation of the Microfluidics, highlighting scale-up strategies and examples using miniaturized systems. Afterward, a methodology for miniaturized devices development for process intensification using numerical simulations was shown. Finally, the conclusions are exposed.

Performance Evaluation of Al2O3 Powder Dispersion by Bead and Ball Mills

2014 ◽  
Vol 682 ◽  
pp. 32-34 ◽  
Author(s):  
N.S. Belousova ◽  
O.A. Goryaynova ◽  
E.V. Melnikova
Keyword(s):  
Particle Size ◽  
Performance Evaluation ◽  
Ball Mill ◽  
Aqueous Suspension ◽  
Ball Mills ◽  
Powder Dispersion ◽  
Maximum Particle Size ◽  
Bead Mill ◽  
Maximum Particle

In this paper the results of alumina aqueous suspension disaggregation with the help of bead and ball mills are shown. The changing of maximum particle size for50 wt. % and 90 wt. % of powder (from lowest to highest size) in suspension dispersed by a bead mill for one hour and ball mill for 48 hours was fixed. In order to achieve powder parameters given by the manufacturer disaggregating process sets was defined.

Effects of Particle Size and Method of Milling on Determination of Morphine in Papaver somniferum L. Straw

1982 ◽  
Vol 65 (3) ◽  
pp. 651-654
Author(s):  
Beatriz Ferreira Engelke ◽  
Phillip G Vincent
Keyword(s):  
Particle Size ◽  
High Pressure ◽  
Liquid Chromatography ◽  
High Pressure Liquid Chromatography ◽  
Reproducibility Of Results ◽  
Ball Mill ◽  
Papaver Somniferum ◽  
Particle Sizes ◽  
Morphine Content

Abstract Different particle sizes of blade- and ball-milled poppy straw were separated and analyzed for morphine by high pressure liquid chromatography. Morphine content varied up to 70% among the different size particles. This may account for discrepancies observed in percentages of morphine found among random aliquots. Homogenizing a carefully quartered sample of blade-milled straw by further pulverization in a percussion ball mill 2 min and taking a quartered aliquot for morphine analysis improved the reproducibility of results.

scholarly journals Opening Material as the Possibility of Elimination Veining in Foundries

2016 ◽  
Vol 16 (3) ◽  
pp. 157-161 ◽  
Author(s):  
M. Hrubovčáková ◽  
I. Vasková ◽  
M. Benková ◽  
M. Conev
Keyword(s):  
Thermal Conductivity ◽  
Particle Size ◽  
Thermal Expansion ◽  
Cast Iron ◽  
Granular Material ◽  
Surface Defects ◽  
Silica Sand ◽  
Iron Castings ◽  
Thermal Dilatation

Abstract The main bulk density representation in the molding material is opening material, refractory granular material with a particle size of 0.02 mm. It forms a shell molds and cores, and therefore in addition to activating the surface of the grain is one of the most important features angularity and particle size of grains. These last two features specify the porosity and therefore the permeability of the mixture, and thermal dilatation of tension from braking dilation, the thermal conductivity of the mixture and even largely affect the strength of molds and cores, and thus the surface quality of castings. [1] Today foundries, which use the cast iron for produce of casts, are struggling with surface defects on the casts. One of these defects are veining. They can be eliminated in several ways. Veining are foundry defects, which arise as a result of tensions generated at the interface of the mold and metal. This tension also arises due to abrupt thermal expansion of silica sand and is therefore in the development of veining on the surface of casts deal primarily influences and characteristics of the filler material – opening material in the production of iron castings.

Petrophysical Rocks: Electrofacies and Lithofacies

2014 ◽  
Author(s):  
John H. Doveton
Keyword(s):  
Particle Size ◽  
Physical Properties ◽  
Sedimentary Rocks ◽  
Well Control ◽  
The Core ◽  
Lateral Extent ◽  
Petrophysical Logs ◽  
Definition Of

Many years ago, the classification of sedimentary rocks was largely descriptive and relied primarily on petrographic methods for composition and granulometry for particle size. The compositional aspect broadly matches the goals of the previous chapter in estimating mineral content from petrophysical logs. With the development of sedimentology, sedimentary rocks were now considered in terms of the depositional environment in which they originated. Uniformitarianism, the doctrine that the present is the key to the past, linked the formation of sediments in the modern day to their ancient lithified equivalents. Classification was now structured in terms of genesis and formalized in the concept of “facies.” A widely quoted definition of facies was given by Reading (1978) who stated, “A facies should ideally be a distinctive rock that forms under certain conditions of sedimentation reflecting a particular process or environment.” This concept identifies facies as process products which, when lithified in the subsurface, form genetic units that can be correlated with well control to establish the geological architecture of a field. The matching of facies with modern depositional analogs means that dimensional measures, such as shape and lateral extent, can be used to condition reasonable geomodels, particularly when well control is sparse or nonuniform. Most wells are logged rather than cored, so that the identification of facies in cores usually provides only a modicum of information to characterize the architecture of an entire field. Consequently, many studies have been made to predict lithofacies from log measurements in order to augment core observations in the development of a satisfactory geomodel that describes the structure of genetic layers across a field. The term “electrofacies” was introduced by Serra and Abbott (1980) as a way to characterize collective associations of log responses that are linked with geological attributes. They defined electrofacies to be “the set of log responses which characterizes a bed and permits it to be distinguished from the others.” Electrofacies are clearly determined by geology, because physical properties of rocks. The intent of electrofacies identification is generally to match them with lithofacies identified in the core or an outcrop.

Characterization of Electrophoretic Lipoprotein Fractions: Immunochemical and Electron Microscopic Studies

1972 ◽  
Vol 18 (6) ◽  
pp. 534-538
Author(s):  
Mario Werner ◽  
Albert L Jones
Keyword(s):  
Electron Microscopy ◽  
Particle Size ◽  
Electrophoretic Pattern ◽  
Electron Microscopic ◽  
Lipoprotein Subfractions ◽  
New Techniques ◽  
Microscopic Studies ◽  
Insight Into

Abstract To improve the characterization of electrophoretic lipoprotein subfractions, we developed two new techniques for analyzing lipoproteins after electrophoresis on thin agarose layers. Overlay with antisera exactly localizes specific apoproteins without any distortion caused by antigen diffusion; electron microscopy of eluted fractions determines the varying particle-size distribution. Applied together, these methods can detect individual differences between hyperlipemic samples that are not immediately apparent in the electrophoretic pattern, and should provide valuable new insight into the classification of hyperlipoproteinemias.

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