scholarly journals Time-dependent expression of cytochrome p450 epoxygenases during human prenatal development

Organogenesis ◽  
2014 ◽  
Vol 10 (1) ◽  
pp. 53-61 ◽  
Author(s):  
Katerina Cizkova ◽  
Anna Konieczna ◽  
Bela Erdosova ◽  
Jiri Ehrmann
Keyword(s):  
Cytochrome P450 ◽  
Prenatal Development ◽  
Time Dependent ◽  
Human Prenatal Development

A Pharmacodynamic Analysis of TCDD-Induced Cytochrome P450 Gene Expression in Multiple Tissues: Dose- and Time-Dependent Effects

1998 ◽  
Vol 151 (2) ◽  
pp. 294-310 ◽  
Author(s):  
Michael J. Santostefano ◽  
Xiaofeng Wang ◽  
Vicki M. Richardson ◽  
David G. Ross ◽  
Michael J. DeVito ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cytochrome P450 ◽  
Time Dependent ◽  
Cytochrome P450 Gene ◽  
P450 Gene ◽  
Pharmacodynamic Analysis

Time-dependent expression and activity of cytochrome P450 1s in early life-stages of the zebrafish (Danio rerio)

2015 ◽  
Vol 22 (21) ◽  
pp. 16319-16328 ◽  
Author(s):  
Jennifer Bräunig ◽  
Sabrina Schiwy ◽  
Oliver Broedel ◽  
Yvonne Müller ◽  
Marcus Frohme ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Danio Rerio ◽  
Early Life ◽  
Time Dependent ◽  
Life Stages ◽  
Early Life Stages ◽  
Expression And Activity

scholarly journals Graphic and movie illustrations of human prenatal development and their application to embryological education based on the human embryo specimens in the Kyoto collection

2006 ◽  
Vol 235 (2) ◽  
pp. 468-477 ◽  
Author(s):  
Shigehito Yamada ◽  
Chigako Uwabe ◽  
Tomoko Nakatsu-Komatsu ◽  
Yutaka Minekura ◽  
Masaji Iwakura ◽  
...  
Keyword(s):  
Human Embryo ◽  
Prenatal Development ◽  
Human Prenatal Development

scholarly journals Epigenetic clocks reveal a rejuvenation event during embryogenesis followed by aging

2021 ◽  
Author(s):  
Csaba Kerepesi ◽  
Bohan Zhang ◽  
Sang-Goo Lee ◽  
Alexandre Trapp ◽  
Vadim N. Gladyshev
Keyword(s):  
Pluripotent Stem Cells ◽  
Prenatal Development ◽  
Biological Age ◽  
Epigenetic Clock ◽  
Ground Zero ◽  
August Weismann ◽  
Age Related ◽  
Epigenetic Age ◽  
Human Prenatal Development ◽  
Changes Over Time

The notion that germline cells do not age goes back to the 19th century ideas of August Weismann. However, being in a metabolically active state, they accumulate damage and other age-related changes over time, i.e., they age. For new life to begin in the same young state, they must be rejuvenated in the offspring. Here, we developed a new multi-tissue epigenetic clock and applied it, together with other aging clocks, to track changes in biological age during mouse and human prenatal development. This analysis revealed a significant decrease in biological age, i.e. rejuvenation, during early stages of embryogenesis, followed by an increase in later stages. We further found that pluripotent stem cells do not age even after extensive passaging and that the examined epigenetic age dynamics is conserved across species. Overall, this study uncovers a natural rejuvenation event during embryogenesis and suggests that the minimal biological age (the ground zero) marks the beginning of organismal aging.

Evaluation of Time-Dependent Cytochrome P450 Inhibition in a High-Throughput, Automated Assay: Introducing a Novel Area Under the Curve Shift Approach

2012 ◽  
Vol 6 (1) ◽  
pp. 43-53 ◽  
Author(s):  
Sophie Mukadam ◽  
Suzanne Tay ◽  
Daniel Tran ◽  
Leslie Wang ◽  
Erlie M. Delarosa ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
High Throughput ◽  
Area Under The Curve ◽  
Time Dependent ◽  
Automated Assay ◽  
Curve Shift
Sign in / Sign up

Export Citation Format

Share Document