scholarly journals Improved immunogenicity of fusions between ethanol-treated cancer cells and dendritic cells exposed to dual TLR stimulation

2013 ◽  
Vol 2 (8) ◽  
pp. e25375 ◽  
Author(s):  
Shigeo Koido ◽  
Sadamu Homma ◽  
Masato Okamoto ◽  
Yoshihisa Namiki ◽  
Shin Kan ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Cancer Cells

scholarly journals Tumor cytotoxicity and immunogenicity of a novel V-jet neon plasma source compared to the kINPen

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Lea Miebach ◽  
Eric Freund ◽  
Stefan Horn ◽  
Felix Niessner ◽  
Sanjeev Kumar Sagwal ◽  
...  
Keyword(s):  
Cell Death ◽  
Dendritic Cells ◽  
Cancer Cells ◽  
Treatment Time ◽  
Plasma Source ◽  
In Vivo Model ◽  
Antitumor Effects ◽  
Plasma Device

AbstractRecent research indicated the potential of cold physical plasma in cancer therapy. The plethora of plasma-derived reactive oxygen and nitrogen species (ROS/RNS) mediate diverse antitumor effects after eliciting oxidative stress in cancer cells. We aimed at exploiting this principle using a newly designed dual-jet neon plasma source (Vjet) to treat colorectal cancer cells. A treatment time-dependent ROS/RNS generation induced oxidation, growth retardation, and cell death within 3D tumor spheroids were found. In TUM-CAM, a semi in vivo model, the Vjet markedly reduced vascularized tumors' growth, but an increase of tumor cell immunogenicity or uptake by dendritic cells was not observed. By comparison, the argon-driven single jet kINPen, known to mediate anticancer effects in vitro, in vivo, and in patients, generated less ROS/RNS and terminal cell death in spheroids. In the TUM-CAM model, however, the kINPen was equivalently effective and induced a stronger expression of immunogenic cancer cell death (ICD) markers, leading to increased phagocytosis of kINPen but not Vjet plasma-treated tumor cells by dendritic cells. Moreover, the Vjet was characterized according to the requirements of the DIN-SPEC 91315. Our results highlight the plasma device-specific action on cancer cells for evaluating optimal discharges for plasma cancer treatment.

Capsaicin-mediated apoptosis of human bladder cancer cells activates dendritic cells via CD91

Nutrition ◽  
2015 ◽  
Vol 31 (4) ◽  
pp. 578-581 ◽  
Author(s):  
Maria Saveria Gilardini Montani ◽  
Donatella D’Eliseo ◽  
Mara Cirone ◽  
Livia Di Renzo ◽  
Alberto Faggioni ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Dendritic Cells ◽  
Cancer Cells ◽  
Human Bladder Cancer ◽  
Human Bladder ◽  
Bladder Cancer Cells ◽  
Human Bladder Cancer Cells

DC-CLM, a cadherin-like molecule cloned from human dendritic cells, inhibits growth of breast cancer cells

2003 ◽  
Vol 129 (1) ◽  
pp. 57-64 ◽  
Author(s):  
Yingming Jiang ◽  
Tao Wan ◽  
Guoyou Chen ◽  
Fangming Xiu ◽  
Dajing Xia ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dendritic Cells ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Human Dendritic Cells

scholarly journals Cross-priming of cyclin B1, MUC-1 and survivin-specific CD8+T cells by dendritic cells loaded with killed allogeneic breast cancer cells

2006 ◽  
Vol 8 (6) ◽  
Author(s):  
Hiroaki Saito ◽  
Peter Dubsky ◽  
Carole Dantin ◽  
Olivera J Finn ◽  
Jacques Banchereau ◽  
...  
Keyword(s):  
Breast Cancer ◽  
T Cells ◽  
Dendritic Cells ◽  
Cancer Cells ◽  
Cd8 T Cells ◽  
Breast Cancer Cells ◽  
Cyclin B1

scholarly journals CD47 as a Potential Target to Therapy for Infectious Diseases

Antibodies ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 44
Author(s):  
Lamin B. Cham ◽  
Tom Adomati ◽  
Fanghui Li ◽  
Murtaza Ali ◽  
Karl S. Lang
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Infectious Diseases ◽  
Cancer Cells ◽  
Therapeutic Potential ◽  
Antiviral Effect ◽  
Surface Expression ◽  
Inhibitory Effect ◽  
Emerging Infections

The integrin associated protein (CD47) is a widely and moderately expressed glycoprotein in all healthy cells. Cancer cells are known to induce increased CD47 expression. Similar to cancer cells, all immune cells can upregulate their CD47 surface expression during infection. The CD47-SIRPa interaction induces an inhibitory effect on macrophages and dendritic cells (dendritic cells) while CD47-thrombospondin-signaling inhibits T cells. Therefore, the disruption of the CD47 interaction can mediate several biologic functions. Upon the blockade and knockout of CD47 reveals an immunosuppressive effect of CD47 during LCMV, influenza virus, HIV-1, mycobacterium tuberculosis, plasmodium and other bacterial pneumonia infections. In our recent study we shows that the blockade of CD47 using the anti-CD47 antibody increases the activation and effector function of macrophages, dendritic cells and T cells during viral infection. By enhancing both innate and adaptive immunity, CD47 blocking antibody promotes antiviral effect. Due to its broad mode of action, the immune-stimulatory effect derived from this antibody could be applicable in nonresolving and (re)emerging infections. The anti-CD47 antibody is currently under clinical trial for the treatment of cancer and could also have amenable therapeutic potential against infectious diseases. This review highlights the immunotherapeutic targeted role of CD47 in the infectious disease realm.

Irradiated Pancreatic Cancer Cells Undergo both Apoptosis and Necrosis, and Could Be Phagocytized by Dendritic Cells

2005 ◽  
Vol 37 (4) ◽  
pp. 228-234 ◽  
Author(s):  
H. Shimamura ◽  
M. Sunamura ◽  
K. Tsuchihara ◽  
S. Egawa ◽  
K. Takeda ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Dendritic Cells ◽  
Cancer Cells ◽  
Pancreatic Cancer Cells ◽  
Apoptosis And Necrosis

21am2-E4 Microfluidic device for one-to-one electrofusion and selective transfer of cytoplasmic contents from cancer cells to dendritic cells

2014 ◽  
Vol 2014.6 (0) ◽  
pp. _21am2-E4--_21am2-E4-
Author(s):  
Yutaro Itagaki ◽  
Kennedy Omondi Okeyo ◽  
Osamu Kurosawa ◽  
Miwako Narita ◽  
Hidehiro Oana ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Cancer Cells ◽  
Microfluidic Device ◽  
Selective Transfer ◽  
One To One

Dendritic cells-based vaccine to inhibit triple-negative breast cancer cells proliferation.

2016 ◽  
Vol 34 (15_suppl) ◽  
pp. e12566-e12566 ◽  
Author(s):  
Yong Huang ◽  
Meijun Long ◽  
Jun An ◽  
Mi Tang ◽  
Renbin Liu
Keyword(s):  
Breast Cancer ◽  
Dendritic Cells ◽  
Cancer Cells ◽  
Triple Negative Breast Cancer ◽  
Breast Cancer Cells ◽  
Triple Negative
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