HER2 monoclonal antibodies that do not interfere with receptor heterodimerization-mediated signaling induce effective internalization and represent valuable components for rational antibody-drug conjugate design

Bart ECG de Goeij; Matthias Peipp; Simone de Haij; Edward N van den Brink; Christian Kellner; Thilo Riedl; Rob de Jong; Tom Vink; Kristin Strumane; Wim K Bleeker; Paul WHI Parren

doi:10.4161/mabs.27705

HER2 monoclonal antibodies that do not interfere with receptor heterodimerization-mediated signaling induce effective internalization and represent valuable components for rational antibody-drug conjugate design

mAbs ◽

10.4161/mabs.27705 ◽

2014 ◽

Vol 6 (2) ◽

pp. 392-402 ◽

Cited By ~ 13

Author(s):

Bart ECG de Goeij ◽

Matthias Peipp ◽

Simone de Haij ◽

Edward N van den Brink ◽

Christian Kellner ◽

...

Keyword(s):

Monoclonal Antibodies ◽

Antibody Drug Conjugate ◽

Drug Conjugate ◽

Antibody Drug

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High-Temperature Reversed-Phase LC Separation of Heavy and Light Chain Fragments of Therapeutic Monoclonal Antibodies and Antibody-Drug Conjugate Produced by Chemical Reduction

Chromatography ◽

10.15583/jpchrom.2019.013 ◽

2019 ◽

Vol 40 (3) ◽

pp. 99-104 ◽

Cited By ~ 3

Author(s):

Sae SOTOMATSU ◽

Tomohiro YAMADA ◽

Hajime MIZUNO ◽

Hideki HAYASHI ◽

Toshimasa TOYO’OKA ◽

...

Keyword(s):

Monoclonal Antibodies ◽

High Temperature ◽

Light Chain ◽

Chemical Reduction ◽

Reversed Phase ◽

Antibody Drug Conjugate ◽

Drug Conjugate ◽

Therapeutic Monoclonal Antibodies ◽

Reversed Phase Lc ◽

Antibody Drug

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Stress Temperature Studies in Small Scale Hastelloy® Drug Substance Containers Lead to Increased Extent of and Increased Variability in Antibody-Drug Conjugate and Monoclonal Antibody Aggregation: Evidence for Novel Oxidation-Induced Crosslinking in Monoclonal Antibodies

Journal of Pharmaceutical Sciences ◽

10.1016/j.xphs.2020.09.052 ◽

2020 ◽

Author(s):

Nathaniel Klair ◽

Michael T. Kim ◽

Aron Lee ◽

Nina J. Xiao ◽

Ankit R. Patel

Keyword(s):

Monoclonal Antibody ◽

Monoclonal Antibodies ◽

Drug Substance ◽

Small Scale ◽

Antibody Drug Conjugate ◽

Drug Conjugate ◽

Antibody Drug

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The efficacy of lapatinib in patients with metastatic HER2 positive breast cancer who received prior therapy with monoclonal antibodies and antibody-drug conjugate: a single institutional experience

Journal of Chemotherapy ◽

10.1080/1120009x.2021.2009722 ◽

2021 ◽

pp. 1-8

Author(s):

Ivana Kolarov Bjelobrk ◽

Jelena Radic ◽

Jasna Trifunovic ◽

Jasna Pesic ◽

Vladimir Vidovic ◽

...

Keyword(s):

Breast Cancer ◽

Monoclonal Antibodies ◽

Antibody Drug Conjugate ◽

Her2 Positive ◽

Drug Conjugate ◽

Prior Therapy ◽

Her2 Positive Breast Cancer ◽

Institutional Experience ◽

Antibody Drug ◽

Positive Breast Cancer

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Abstract 3575: Novel targets and monoclonal antibodies for antibody-drug conjugate therapy

10.1158/1538-7445.am2015-3575 ◽

2015 ◽

Author(s):

Matteo Parri ◽

Susanna Campagnoli ◽

Alberto Grandi ◽

Elisa De Camilli ◽

Paolo Sarmientos ◽

...

Keyword(s):

Monoclonal Antibodies ◽

Antibody Drug Conjugate ◽

Drug Conjugate ◽

Novel Targets ◽

Antibody Drug

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Practical method development for the separation of monoclonal antibodies and antibody-drug-conjugate species in hydrophobic interaction chromatography, part 1: optimization of the mobile phase

Journal of Pharmaceutical and Biomedical Analysis ◽

10.1016/j.jpba.2015.11.011 ◽

2016 ◽

Vol 118 ◽

pp. 393-403 ◽

Cited By ~ 38

Author(s):

Marta Rodriguez-Aller ◽

Davy Guillarme ◽

Alain Beck ◽

Szabolcs Fekete

Keyword(s):

Monoclonal Antibodies ◽

Hydrophobic Interaction ◽

Mobile Phase ◽

Method Development ◽

Hydrophobic Interaction Chromatography ◽

Practical Method ◽

Antibody Drug Conjugate ◽

Drug Conjugate ◽

Antibody Drug

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Human Tumor Xenografts in Mouse as a Model for Evaluating Therapeutic Efficacy of Monoclonal Antibodies or Antibody-Drug Conjugate Targeting Receptor Tyrosine Kinases

Methods in Molecular Biology - Receptor Tyrosine Kinases ◽

10.1007/978-1-4939-1789-1_14 ◽

2014 ◽

pp. 151-159 ◽

Cited By ~ 3

Author(s):

Liang Feng ◽

Wei Wang ◽

Hang-Ping Yao ◽

Jianwei Zhou ◽

Ruiwen Zhang ◽

...

Keyword(s):

Monoclonal Antibodies ◽

Tyrosine Kinases ◽

Therapeutic Efficacy ◽

Receptor Tyrosine Kinases ◽

Human Tumor ◽

Antibody Drug Conjugate ◽

Human Tumor Xenografts ◽

Tumor Xenografts ◽

Drug Conjugate ◽

Antibody Drug

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Practical method development for the separation of monoclonal antibodies and antibody-drug-conjugate species in hydrophobic interaction chromatoraphy, part 2: Optimization of the phase system

Journal of Pharmaceutical and Biomedical Analysis ◽

10.1016/j.jpba.2016.01.037 ◽

2016 ◽

Vol 121 ◽

pp. 161-173 ◽

Cited By ~ 33

Author(s):

Alessandra Cusumano ◽

Davy Guillarme ◽

Alain Beck ◽

Szabolcs Fekete

Keyword(s):

Monoclonal Antibodies ◽

Hydrophobic Interaction ◽

Method Development ◽

Practical Method ◽

Phase System ◽

Antibody Drug Conjugate ◽

Drug Conjugate ◽

Antibody Drug

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Antibody-drug Conjugate ABBV-838

10.32388/bdge66 ◽

2020 ◽

Author(s):

Keyword(s):

Antibody Drug Conjugate ◽

Drug Conjugate ◽

Antibody Drug

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Anti-CD33 Antibody-drug Conjugate IMGN779

10.32388/c3jmqs ◽

2020 ◽

Author(s):

Keyword(s):

Antibody Drug Conjugate ◽

Drug Conjugate ◽

Antibody Drug

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A Study of CC-99712, a BCMA Antibody-Drug Conjugate, in Subjects With Relapsed and Refractory Multiple Myeloma

Case Medical Research ◽

10.31525/ct1-nct04036461 ◽

2019 ◽

Author(s):

Keyword(s):

Multiple Myeloma ◽

Antibody Drug Conjugate ◽

Refractory Multiple Myeloma ◽

Drug Conjugate ◽

Antibody Drug

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