scholarly journals The role of follicular helper T cells and the germinal center in HIV-1 gp120 DNA prime and gp120 protein boost vaccination

2014 ◽  
Vol 10 (7) ◽  
pp. 1985-1992 ◽  
Author(s):  
Kristin Hollister ◽  
Yuxin Chen ◽  
Shixia Wang ◽  
Hao Wu ◽  
Arpita Mondal ◽  
...  
Keyword(s):  
T Cells ◽  
Germinal Center ◽  
Helper T Cells ◽  
Follicular Helper T Cells ◽  
Boost Vaccination ◽  
Follicular Helper ◽  
Gp120 Protein ◽  
Protein Boost ◽  
Hiv 1

scholarly journals PPARγ Negatively Regulates T Cell Activation to Prevent Follicular Helper T Cells and Germinal Center Formation

PLoS ONE ◽  
2014 ◽  
Vol 9 (6) ◽  
pp. e99127 ◽  
Author(s):  
Hong-Jai Park ◽  
Do-Hyun Kim ◽  
Jin-Young Choi ◽  
Won-Ju Kim ◽  
Ji Yun Kim ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
T Cell Activation ◽  
Germinal Center ◽  
Cell Activation ◽  
Helper T Cells ◽  
Follicular Helper T Cells ◽  
Follicular Helper ◽  
Germinal Center Formation

scholarly journals CD10 delineates a subset of human IL-4 producing follicular helper T cells involved in the survival of follicular lymphoma B cells

Blood ◽  
2015 ◽  
Vol 125 (15) ◽  
pp. 2381-2385 ◽  
Author(s):  
Patricia Amé-Thomas ◽  
Sylvia Hoeller ◽  
Catherine Artchounin ◽  
Jan Misiak ◽  
Mounia Sabrina Braza ◽  
...  
Keyword(s):  
T Cells ◽  
B Cells ◽  
Follicular Lymphoma ◽  
B Cell ◽  
Germinal Center ◽  
Helper T Cells ◽  
Follicular Helper T Cells ◽  
Follicular Helper ◽  
Key Points ◽  
Cell Niche

Key Points CD10 identifies a unique subset of fully functional germinal center TFH that are activated and amplified within the FL cell niche. FL CD10pos TFH specifically display an IL-4hiIFN-γlo cytokine profile and encompass the malignant B-cell-supportive TFH subset.

The potential role of follicular helper T cells and helper T cells type 1 in Warthin tumour

2021 ◽  
Vol 220 ◽  
pp. 153386
Author(s):  
Yoshiaki Kobayashi ◽  
Nozomu Kurose ◽  
Xin Guo ◽  
Akihiro Shioya ◽  
Morimasa Kitamura ◽  
...  
Keyword(s):  
T Cells ◽  
Potential Role ◽  
Helper T Cells ◽  
Follicular Helper T Cells ◽  
Warthin Tumour ◽  
Follicular Helper

scholarly journals Repression of miR-31 by BCL6 stabilizes the helper function of human follicular helper T cells

2017 ◽  
Vol 114 (48) ◽  
pp. 12797-12802 ◽  
Author(s):  
A. Ripamonti ◽  
E. Provasi ◽  
M. Lorenzo ◽  
M. De Simone ◽  
V. Ranzani ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Helper T Cells ◽  
Follicular Helper T Cells ◽  
Follicular Helper ◽  
Human T Cell ◽  
Helper Function ◽  
Follicular Helper T Cell ◽  
And Function

Follicular helper T cells (TFHs) are a key component of adaptive immune responses as they help antibody production by B cells. Differentiation and function of TFH cells are controlled by the master gene BCL6, but it is largely unclear how this transcription repressor specifies the TFH program. Here we asked whether BCL6 controlled helper function through down-regulation of specific microRNAs (miRNAs). We first assessed miRNA expression in TFH cells and defined a TFH-specific miRNA signature. We report that hsa–miR-31–5p (miR-31) is down-regulated in TFH; we showed that BCL6 suppresses miR-31 expression by binding to its promoter; and we demonstrated that miR-31 inhibits the expression of molecules that control T-helper function, such as CD40L and SAP. These findings identify a BCL6-initiated inhibitory circuit that stabilizes the follicular helper T cell program at least in part through the control of miRNA transcription. Although BCL6 controls TFH activity in human and mouse, the role of miR-31 is restricted to human TFH cell differentiation, reflecting a species specificity of the miR-31 action. Our findings highlight miR-31 as a possible target to modulate human T cell dependent antibody responses in the settings of infection, vaccination, or immune dysregulation.

scholarly journals The role of follicular helper T cells in mycobacterial infection

2013 ◽  
Vol 4 ◽  
Author(s):  
Shimohakamada Yoko ◽  
Tamura Toshiki ◽  
Makino Masahiko ◽  
Nutt Stephen
Keyword(s):  
T Cells ◽  
Mycobacterial Infection ◽  
Helper T Cells ◽  
Follicular Helper T Cells ◽  
Follicular Helper
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