scholarly journals Characterization and long-term persistence of immune response following two doses of an AS03A-adjuvanted H1N1 influenza vaccine in healthy Japanese adults

2012 ◽  
Vol 8 (2) ◽  
pp. 260-266 ◽  
Author(s):  
Hideyuki Ikematsu ◽  
Hideaki Nagai ◽  
Masahiro Kawashima ◽  
Yasunobu Kawakami ◽  
Kazuyoshi Tenjinbaru ◽  
...  
Keyword(s):  
Immune Response ◽  
Influenza Vaccine ◽  
H1n1 Influenza ◽  
Japanese Adults

scholarly journals Evaluation of immune response following one dose of an AS03A-adjuvanted H1N1 2009 pandemic influenza vaccine in Japanese adults 65 years of age or older

2012 ◽  
Vol 8 (8) ◽  
pp. 1119-1125 ◽  
Author(s):  
Hideyuki Ikematsu ◽  
Kazuyoshi Tenjinbaru ◽  
Ping Li ◽  
Anuradha Madan ◽  
David Vaughn
Keyword(s):  
Immune Response ◽  
Influenza Vaccine ◽  
Pandemic Influenza ◽  
Japanese Adults

scholarly journals Immune Response to Seasonal Influenza Vaccine in Patients with Relapsing-Remitting Multiple Sclerosis Receiving Long-term Daclizumab Beta

2017 ◽  
Vol 19 (3) ◽  
pp. 141-147 ◽  
Author(s):  
Lahar Mehta ◽  
Kimberly Umans ◽  
Gulden Ozen ◽  
Randy R. Robinson ◽  
Jacob Elkins
Keyword(s):  
Immune Response ◽  
Influenza Vaccine ◽  
Seasonal Influenza ◽  
Geometric Mean ◽  
Geometric Mean Titer ◽  
Seasonal Influenza Vaccine ◽  
Relapsing Remitting ◽  
Relapsing Remitting Multiple Sclerosis

Background: For patients with relapsing-remitting multiple sclerosis (RRMS) undergoing continuous immunomodulatory therapy, understanding whether vaccinations can be performed safely and effectively is important. We tested the immune response to inactivated seasonal influenza vaccine during long-term daclizumab beta treatment. Methods: In this prospective, open-label, single-arm extension SELECTED study, an optional vaccine substudy was performed on patients with RRMS who had already received daclizumab beta for 1 to 2 years in previous studies. Patients were administered the seasonal vaccine as a single intramuscular dose containing three inactivated influenza virus strains: A/California/7/2009 (A/H1N1), A/Texas/50/2012 (A/H3N2), and B/Massachusetts/2/2012 (B). Endpoints included proportion of patients achieving seroprotection, proportion of patients who seroconverted, geometric mean titer ratio before and after vaccination, and adverse events reported during 28-day follow-up. Results: Ninety patients received the influenza vaccine (mean previous daclizumab beta exposure, 49.6 doses). Seroprotection (anti–hemagglutination immunoglobulin G titer ≥40) was detected in 92% (95% confidence interval [CI], 85%–97%) of patients for A/H1N1, 91% (83%–96%) for A/H3N2, and 67% (56%–76%) for B. The proportion of patients who seroconverted was 69% (95% CI, 58%–78%) for A/H1N1, 69% (58%–78%) for A/H3N2, and 44% (34%–55%) for B. The anti–hemagglutination immunoglobulin geometric mean titer ratio was 7.7 for A/H1N1, 9.0 for A/H3N2, and 4.3 for B. There were no significant adverse events considered related to vaccination during 28-day follow-up. Conclusions: Patients with RRMS receiving long-term daclizumab beta treatment mounted an immune response to the seasonal influenza vaccine at levels considered to confer protection. No major or new safety issues were identified.

Long-term immunogenicity of influenza vaccine among the elderly: Risk factors for poor immune response and persistence

Vaccine ◽  
2010 ◽  
Vol 28 (23) ◽  
pp. 3929-3935 ◽  
Author(s):  
Joon Young Song ◽  
Hee Jin Cheong ◽  
In Sook Hwang ◽  
Won Suk Choi ◽  
Yu Mi Jo ◽  
...  
Keyword(s):  
Risk Factors ◽  
Immune Response ◽  
Influenza Vaccine ◽  
The Elderly

scholarly journals Higher Antigen Content Improves the Immune Response to 2009 H1N1 Influenza Vaccine in HIV-Infected Adults: A Randomized Clinical Trial

2012 ◽  
Vol 205 (5) ◽  
pp. 703-712 ◽  
Author(s):  
Hana M. El Sahly ◽  
Charles Davis ◽  
Karen Kotloff ◽  
Jeffery Meier ◽  
Patricia L. Winokur ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Immune Response ◽  
Influenza Vaccine ◽  
Randomized Clinical Trial ◽  
H1n1 Influenza ◽  
2009 H1n1

scholarly journals Socioeconomic Status and Long-Term Care Provision to Parents in Japan

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 725-725
Author(s):  
Yoko Ibuka ◽  
Yui Ohtsu
Keyword(s):  
Socioeconomic Status ◽  
Long Term Care ◽  
Living Condition ◽  
Care Provision ◽  
Burden Of Care ◽  
Care Needs ◽  
Term Care ◽  
Japanese Adults ◽  
The Relationship

Abstract Socioeconomic status (SES) is generating considerable interest in terms of health of individuals, but how it is associated with long-term care has not been established yet. We study the relationship between SES and long-term care provision to parents among the Japanese adults using JSTAR. We use the following six measures of SES for the analysis: income, asset, expenditure, living condition, housing condition and education. We find a greater probability of care provision to parents among those in higher SES categories for some SES measures, compared to the lowest category. However, after considering the survival probability of parents, the relationship is reversed and the probability of care provision is found to be greater among lower SES individuals. The association is more pronounced among males. The association is likely to be partly mediated by care needs of parents. These results suggest a higher burden of care disproportionately falls in low SES individuals.

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