scholarly journals EGFR-dependent downregulation of Capicua and the establishment of Drosophila dorsoventral polarity

Fly ◽  
2012 ◽  
Vol 6 (4) ◽  
pp. 234-239 ◽  
Author(s):  
María José Andreu ◽  
Leiore Ajuria ◽  
Núria Samper ◽  
Esther González-Pérez ◽  
Sonsoles Campuzano ◽  
...  
Keyword(s):  
Dorsoventral Polarity

Genes that control dorsoventral polarity affect gene expression along the anteroposterior axis of the Drosophila embryo

Development ◽  
1987 ◽  
Vol 99 (3) ◽  
pp. 327-332 ◽  
Author(s):  
S.B. Carroll ◽  
G.M. Winslow ◽  
V.J. Twombly ◽  
M.P. Scott
Keyword(s):  
Gene Expression ◽  
Cell Fate ◽  
Maternal Effect ◽  
Positional Information ◽  
Drosophila Embryo ◽  
Dorsoventral Polarity ◽  
Anteroposterior Axis ◽  
Positional Marker ◽  
Control Pattern ◽  
The Relationship

At least 13 genes control the establishment of dorsoventral polarity in the Drosophila embryo and more than 30 genes control the anteroposterior pattern of body segments. Each group of genes is thought to control pattern formation along one body axis, independently of the other group. We have used the expression of the fushi tarazu (ftz) segmentation gene as a positional marker to investigate the relationship between the dorsoventral and anteroposterior axes. The ftz gene is normally expressed in seven transverse stripes. Changes in the striped pattern in embryos mutant for other genes (or progeny of females homozygous for maternal-effect mutations) can reveal alterations of cell fate resulting from such mutations. We show that in the absence of any of ten maternal-effect dorsoventral polarity gene functions, the characteristic stripes of ftz protein are altered. Normally there is a difference between ftz stripe spacing on the dorsal and ventral sides of the embryo; in dorsalized mutant embryos the ftz stripes appear to be altered so that dorsal-type spacing occurs on all sides of the embryo. These results indicate that cells respond to dorsoventral positional information in establishing early patterns of gene expression along the anteroposterior axis and that there may be more significant interactions between the different axes of positional information than previously determined.

scholarly journals Specification of dorsoventral polarity in the embryonic chick mesencephalon and its presumptive role in midbrain morphogenesis

2005 ◽  
Vol 233 (3) ◽  
pp. 907-920 ◽  
Author(s):  
Naixin Li ◽  
Amata Hornbruch ◽  
Ruth Klafke ◽  
Barbara Katzenberger ◽  
Andrea Wizenmann
Keyword(s):  
Embryonic Chick ◽  
Dorsoventral Polarity

scholarly journals Evolution of limb development in cephalopod mollusks

2018 ◽  
Author(s):  
Oscar A. Tarazona ◽  
Davys H. Lopez ◽  
Leslie A. Slota ◽  
Martin J. Cohn
Keyword(s):  
Ventral Sucker ◽  
Limb Development ◽  
Common Ancestor ◽  
Ectopic Expression ◽  
Mirror Image ◽  
Signaling Networks ◽  
Limb Buds ◽  
Dorsoventral Polarity ◽  
Developmental Mechanisms ◽  
Parallel Activation

AbstractCephalopod mollusks evolved numerous anatomical novelties, including arms and tentacles, but little is known about the developmental mechanisms underlying cephalopod limb evolution. Here we show that all three axes of cuttlefish limbs are patterned by the same signaling networks that act in vertebrates and arthropods, although they evolved limbs independently. In cuttlefish limb buds, Hedgehog is expressed anteriorly. Posterior transplantation of Hedgehog-expressing cells induced mirror-image limb duplications. Bmp and Wnt signals, which establish dorsoventral polarity in vertebrate and arthropod limbs, are similarly polarized in cuttlefish. Inhibition of Bmp2/4 dorsally caused ectopic expression of Notum, which marks the ventral sucker field, and ectopic sucker development. Cuttlefish also show proximodistal regionalization of Hth, Exd, Dll, Dac, Sp8/9, and Wnt expression, which delineates arm and tentacle sucker fields. These results suggest that cephalopod limbs evolved by parallel activation of a genetic program for appendage development that was present in the bilaterian common ancestor.

Interaction of the pelle kinase with the membrane-associated protein tube is required for transduction of the dorsoventral signal in Drosophila embryos

Development ◽  
1995 ◽  
Vol 121 (7) ◽  
pp. 2209-2218 ◽  
Author(s):  
R.L. Galindo ◽  
D.N. Edwards ◽  
S.K. Gillespie ◽  
S.A. Wasserman
Keyword(s):  
Plasma Membrane ◽  
Protein Kinase ◽  
Catalytic Domain ◽  
Drosophila Embryo ◽  
Related Protein ◽  
Yeast Two Hybrid ◽  
Dorsoventral Polarity ◽  
Intracellular Signal ◽  
Two Hybrid ◽  
Drosophila Embryos

Within the Drosophila embryo, tube and the protein kinase pelle transduce an intracellular signal generated by the transmembrane receptor Toll. This signal directs import of the rel-related protein dorsal into ventral and ventrolateral nuclei, thereby establishing dorsoventral polarity. We show by immunolocalization that tube protein associates with the plasma membrane during interphase. We also find that tube sequences required for signaling interact with pelle in a yeast two-hybrid assay. We demonstrate that fusion of the pelle catalytic domain to the transmembrane receptor torso is sufficient to induce ventral fates; this activity is independent of Toll or tube. Lastly, we find that fusion of the tube protein to torso also induces ventral fates, but only in the presence of functional pelle. We propose a model wherein tube activates pelle by recruiting it to the plasma membrane, thereby propagating the axis-determining signal.

pelle encodes a protein kinase required to establish dorsoventral polarity in the Drosophila embryo

Cell ◽  
1993 ◽  
Vol 72 (4) ◽  
pp. 515-525 ◽  
Author(s):  
Christopher A. Shelton ◽  
Steven A. Wasserman
Keyword(s):  
Protein Kinase ◽  
Drosophila Embryo ◽  
Dorsoventral Polarity
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