scholarly journals Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses

Epigenetics ◽  
2008 ◽  
Vol 3 (2) ◽  
pp. 97-106 ◽  
Author(s):  
Tim F. Oberlander ◽  
Joanne Weinberg ◽  
Michael Papsdorf ◽  
Ruth Grunau ◽  
Shaila Misri ◽  
...  
Keyword(s):  
Glucocorticoid Receptor ◽  
Maternal Depression ◽  
Prenatal Exposure ◽  
Stress Responses ◽  
Receptor Gene ◽  
Glucocorticoid Receptor Gene

scholarly journals Environmental programming of stress responses through DNA methylation: life at the interface between a dynamic environment and a fixed genome

2005 ◽  
Vol 7 (2) ◽  
pp. 103-123 ◽  
Keyword(s):  
Dna Methylation ◽  
Glucocorticoid Receptor ◽  
Stress Responses ◽  
Chromatin Structure ◽  
Causal Relation ◽  
Epigenetic Modification ◽  
Receptor Gene ◽  
Receptor Expression ◽  
Critical Question ◽  
Glucocorticoid Receptor Gene

Early experience permanently alters behavior and physiology. These effects are, in part, mediated by sustained alterations in gene expression in selected brain regions. The critical question concerns the mechanism of these environmental "programming" effects. We examine this issue with an animal model that studies the consequences of variations in mother-infant interactions on the development of individual differences in behavioral and endocrine responses to stress in adulthood. Increased levels of pup licking/grooming by rat mothers in the first week of life alter DNA structure at a glucocorticoid receptor gene promoter in the hippocampus of the offspring. Differences in the DNA methylation pattern between the offspring of high- and low-licking/grooming mothers emerge over the first week of life; they are reversed with cross-fostering; they persist into adulthood; and they are associated with altered histone acetylation and transcription factor (nerve growth factor-induced clone A [NGFIA]) binding to the glucocorticoid receptor promoter. DNA methylation alters glucocorticoid receptor expression through modifications of chromatin structure. Pharmacological reversal of the effects on chromatin structure completely eliminates the effects of maternal care on glucocorticoid receptor expression and hypothalamic-pituitary-adrenal (HPA) responses to stress, thus suggesting a causal relation between the maternally induced, epigenetic modification of the glucocorticoid receptor gene and the effects on stress responses in the offspring. These findings demonstrate that the structural modifications of the DNA can be established through environmental programming and that, in spite of the inherent stability of this epigenomic marker, it is dynamic and potentially reversible.

Associations of Chinese social face with cortisol level and glucocorticoid receptor gene

2021 ◽  
Author(s):  
Pingyuan Gong ◽  
Wenxuan Guo ◽  
Xia Zhang ◽  
Keqing Cao ◽  
Quanhe Wang ◽  
...  
Keyword(s):  
Glucocorticoid Receptor ◽  
Cortisol Level ◽  
Receptor Gene ◽  
Glucocorticoid Receptor Gene

scholarly journals Meta-analysis on the effect of the N363S polymorphism of the glucocorticoid receptor gene (GRL) on human obesity

2006 ◽  
Vol 7 (1) ◽  
Author(s):  
Amelia Marti ◽  
M Carmen Ochoa ◽  
Almudena Sánchez-Villegas ◽  
J Alfredo Martínez ◽  
Miguel Angel Martínez-González ◽  
...  
Keyword(s):  
Glucocorticoid Receptor ◽  
Meta Analysis ◽  
Receptor Gene ◽  
Human Obesity ◽  
Glucocorticoid Receptor Gene

The glucocorticoid receptor gene as a candidate for gene therapy in asthma

Gene Therapy ◽  
1999 ◽  
Vol 6 (2) ◽  
pp. 245-252 ◽  
Author(s):  
M Mathieu ◽  
C Gougat ◽  
D Jaffuel ◽  
M Danielsen ◽  
P Godard ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Glucocorticoid Receptor ◽  
Receptor Gene ◽  
Glucocorticoid Receptor Gene

Lower glucocorticoid receptor gene expression and glucocorticoid receptor variants are associated with cocaine use and addiction

2017 ◽  
Vol 83 ◽  
pp. 81 ◽  
Author(s):  
Andrea B. Schote ◽  
Kristina Jäger ◽  
Sara L. Kroll ◽  
Matthias Vonmoos ◽  
Lea M. Hulka ◽  
...  
Keyword(s):  
Gene Expression ◽  
Glucocorticoid Receptor ◽  
Receptor Gene ◽  
Cocaine Use ◽  
Glucocorticoid Receptor Gene ◽  
Receptor Gene Expression
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