scholarly journals Inhibition of class I histone deacetylases in non-small cell lung cancer by honokiol leads to suppression of cancer cell growth and induction of cell death in vitro and in vivo

Epigenetics ◽  
2013 ◽  
Vol 8 (1) ◽  
pp. 54-65 ◽  
Author(s):  
Tripti Singh ◽  
Ram Prasad ◽  
Santosh K. Katiyar
Keyword(s):  
Lung Cancer ◽  
Cell Death ◽  
Cell Growth ◽  
Small Cell Lung Cancer ◽  
Histone Deacetylases ◽  
Small Cell ◽  
Small Cell Lung ◽  
Cancer Cell Growth

microRNA miR-10b inhibition reduces cell proliferation and promotes apoptosis in non-small cell lung cancer (NSCLC) cells

2015 ◽  
Vol 11 (7) ◽  
pp. 2051-2059 ◽  
Author(s):  
Junchao Huang ◽  
Chengchao Sun ◽  
Suqing Wang ◽  
Qiqiang He ◽  
Dejia Li
Keyword(s):  
Lung Cancer ◽  
Cell Proliferation ◽  
Cell Growth ◽  
Small Cell Lung Cancer ◽  
Small Cell ◽  
Lung Cancer Cell ◽  
Small Cell Lung ◽  
Cancer Cell Growth

Anti-miR-10b inhibits lung cancer cell growth and induces apoptosis in vitro and in vivo.

scholarly journals MicroRNA-205 targets SMAD4 in non-small cell lung cancer and promotes lung cancer cell growth in vitro and in vivo

Oncotarget ◽  
2016 ◽  
Vol 8 (19) ◽  
pp. 30817-30829 ◽  
Author(s):  
Yuanyuan Zeng ◽  
Jianjie Zhu ◽  
Dan Shen ◽  
Hualong Qin ◽  
Zhe Lei ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Growth ◽  
Small Cell Lung Cancer ◽  
Cancer Cell ◽  
Small Cell ◽  
Lung Cancer Cell ◽  
Small Cell Lung ◽  
Cancer Cell Growth

scholarly journals Epigenetic control of INSL4 promotes cell growth and invasiveness in Non-Small-Cell Lung Cancer

2020 ◽  
Author(s):  
Damiano Scopetti ◽  
Danilo Piobbico ◽  
Cinzia Brunacci ◽  
Stefania Pieroni ◽  
Guido Bellezza ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Growth ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Relaxin Family ◽  
Nsclc Patients

Abstract Background Non-Small Cell Lung Cancer accounts for 80–85% of all forms of Lung Cancer as leading cause of cancer-related death in human. Despite remarkable advances in the diagnosis and therapy of Lung Cancer, no significant improvements have thus far been achieved in terms of patients’ prognosis. Here, we investigated the role of INSL4 – a member of the relaxin family –in NSCLC.Methods We permanently overexpressed INSL4 in NSCLC cells in vitro to analyse the growth rate and the tumourigenic features. We further investigated the signalling pathways engaged in INSL4 overexpressing cells and the tumour growth ability by studying the tumour development in a patient derived tumour xenograft mouse model. Results We found a cell growth promoting effect by INSL4 overexpression in vitro in H1299 cells and in vivo in NOD/SCID mice. Surprisingly, in NSCLC-A549 cells, stable INSL4 overexpression has not showed similar effect, despite has an INSL4-mRNA expressed up to 22.000 fold more respect H1299. The INSL4-mRNA analysis of eight different NSCLC-derived cell lines, has revealed a great discrepancy between the amount of INSL4-mRNA and specific protein. Notably, similar result has been observed in studied NSCLC patients analysing and comparing INSL4 mRNA and protein expression. However, in a cohort of NSCLC patients, we found a significant inverse correlation between INSL4 expression and Overall Survival.Conclusions By combining the results from the in vitro and in vivo models and in silico analysis in patients whose NSCLCs adenocarcinoma spontaneously expressed high levels of INSL4 our results suggest that epigenetic modifications that affect INSL4 does not allow to assess precision therapy in selected patients without consider protein INSL4 amount.

scholarly journals MicroRNA-1304 suppresses human non-small cell lung cancer cell growth in vitro by targeting heme oxygenase-1

2016 ◽  
Vol 38 (1) ◽  
pp. 110-119 ◽  
Author(s):  
Cheng-gang Li ◽  
Meng-fan Pu ◽  
Chun-zhu Li ◽  
Man Gao ◽  
Ming-xia Liu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Growth ◽  
Small Cell Lung Cancer ◽  
Heme Oxygenase ◽  
Small Cell ◽  
Heme Oxygenase 1 ◽  
Lung Cancer Cell ◽  
Small Cell Lung ◽  
Cancer Cell Growth

scholarly journals The requirement of mitochondrial RNA polymerase for non-small cell lung cancer cell growth

2021 ◽  
Vol 12 (8) ◽  
Author(s):  
Tong Zhou ◽  
Yong-Hua Sang ◽  
Shang Cai ◽  
Chun Xu ◽  
Min-hua Shi
Keyword(s):  
Lung Cancer ◽  
Cell Growth ◽  
Rna Polymerase ◽  
Small Cell Lung Cancer ◽  
Small Cell ◽  
Mrna Levels ◽  
Small Cell Lung ◽  
Cancer Cell Growth ◽  
Cancer Tissues

AbstractPOLRMT (RNA polymerase mitochondrial) is responsible for the transcription of mitochondrial genome encoding key components of oxidative phosphorylation. This process is important for cancer cell growth. The current study tested expression and potential functions of POLRMT in non-small cell lung cancer (NSCLC). TCGA cohorts and the results from the local lung cancer tissues showed that POLRMT is overexpressed in human lung cancer tissues. In both primary human NSCLC cells and A549 cells, POLRMT silencing (by targeted lentiviral shRNAs) or knockout (through CRSIPR/Cas9 gene editing method) potently inhibited cell viability, proliferation, migration, and invasion, and induced apoptosis activation. On the contrast, ectopic overexpression of POLRMT using a lentiviral construct accelerated cell proliferation and migration in NSCLC cells. The mtDNA contents, mRNA levels of mitochondrial transcripts, and subunits of respiratory chain complexes, as well as S6 phosphorylation, were decreased in POLRMT-silenced or -knockout NSCLC cells, but increased after ectopic POLRMT overexpression. In vivo, intratumoral injection of POLRMT shRNA adeno-associated virus (AAV) potently inhibited NSCLC xenograft growth in severe combined immune deficiency mice. The mtDNA contents, mRNA levels of mitochondria respiratory chain complex subunits, and S6 phosphorylation were decreased in POLRMT shRNA AAV-injected NSCLC xenograft tissues. These results show that POLRMT is a novel and important oncogene required for NSCLC cell growth in vitro and in vivo.

scholarly journals Genistein enhances the effect of cisplatin on the inhibition of non-small cell lung cancer A549 cell growth in vitro and in vivo

2014 ◽  
Vol 8 (6) ◽  
pp. 2806-2810 ◽  
Author(s):  
DEZHI LIU ◽  
LING YAN ◽  
LAN WANG ◽  
WEICHENG TAI ◽  
WEILI WANG ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Growth ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
A549 Cell ◽  
Small Cell ◽  
Small Cell Lung ◽  
Lung Cancer A549 Cell
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