scholarly journals The relevance of the vitamin D endocrine system (VDES) for tumorigenesis, prevention, and treatment of non-melanoma skin cancer (NMSC)

2013 ◽  
Vol 5 (1) ◽  
pp. 38-50 ◽  
Author(s):  
Jörg Reichrath ◽  
Sandra Reichrath
Keyword(s):  
Vitamin D ◽  
Skin Cancer ◽  
Endocrine System ◽  
Non Melanoma Skin Cancer ◽  
Prevention And Treatment ◽  
Melanoma Skin

scholarly journals Vitamin D status and its relation with insulin resistance and VDR-FokI polymorphism in Iranian non-melanoma skin cancer (NMSC) patients: a case-control study

2019 ◽  
Author(s):  
Fatemeh Rezaiian ◽  
Sayed Hossein Davoodi ◽  
Bahareh Nikooyeh ◽  
Amir Houshang Ehsani ◽  
Ali Kalayi ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Vitamin D ◽  
Skin Cancer ◽  
Case Control Study ◽  
Sunlight Exposure ◽  
Vitamin D Status ◽  
Fasting Serum ◽  
Non Melanoma Skin Cancer ◽  
Control Study ◽  
Melanoma Skin

Abstract Background: Sunlight exposure, the main source of endogenous vitamin D synthesis, may increase the risk of non-melanoma skin cancer (NMSC) development. Vitamin D receptor (VDR) polymorphisms are associated with 25(OH)D levels, cancer development and insulin resistance. This study was aimed to examine the associations among vitamin D status, VDR FokI polymorphism, insulin resistance and NMSC. Methods: This case-control study included 73 diagnosed cases of NMSC and 72 healthy controls from dermatology clinics at Razi Hospital, Tehran, Iran. A questionnaire was used to assess sunlight exposure. The extracted DNA from whole blood samples were genotyped. Fasting serum 25-hydroxyvitaminD (25(OH)D)), lipid profile, glucose, and insulin were measured. To evaluate insulin resistance, HOMA-IR formula was used. Results: We found a significant higher duration of cumulative sunlight exposure in cases compared with controls (p<0.001). However, 25(OH)D concentrations were not significantly different between cases and controls (30±15 vs. 29±15 ng/mL, p=0.78). Higher levels of insulin (p = 0.004) and HOMA-IR score (p= 0.019) were observed in Ff and ff genotype of FokI. We did not observe any significant increased risk of NMSC due to f allele, as compared with FF (OR =2.33, 95% CI 0.81-6.75, p=0.12). The components of lipid profile, fasting serum glucose, iPTH and anthropometric measures did not differ significantly across VDR genotypes. Conclusion: In conclusion, sunlight exposure was associated with NMSC risk. VDR FokI polymorphisms appears to influence insulin resistance in the NMSC patients. Keywords: sun exposure; non-melanoma skin cancer; polymorphisms; insulin resistance

scholarly journals Vitamin D Receptor Polymorphisms and Non-Melanoma Skin Cancer Risk: A Case-Control Study

2020 ◽  
Vol 9 (12) ◽  
pp. 3819
Author(s):  
Carolina Morgado-Águila ◽  
Purificación Rey-Sánchez ◽  
Guadalupe Gil-Fernández ◽  
María Carmen Costa-Fernández ◽  
Francisco José Rodríguez-Velasco
Keyword(s):  
Vitamin D ◽  
Skin Cancer ◽  
Basal Cell ◽  
Protective Factor ◽  
Case Control Study ◽  
Case Control ◽  
Non Melanoma Skin Cancer ◽  
Skin Cancers ◽  
Control Study ◽  
Melanoma Skin

Exposure to sunlight is the major source of vitamin D and the main environmental cause of non-melanocytic skin cancers. Vitamin D, partly mediated through the vitamin D receptor (VDR), has potential therapeutic applications in skin cancer. The aim of this study was to investigate the association of BsmI and ApaI VDR polymorphisms among patients with non-melanoma cancers and controls. An observational case-control study was conducted in a sample of 154 subjects. We observed no significant effects between these polymorphisms and skin cancer risk. When stratified for gender, GG and AG BsmI polymorphisms significantly increased the risk of basal cell carcinomas in males. In relation to ApaI, all three polymorphisms significantly increased the risk of basal cell carcinoma in males. When stratified for age, we found that being 70 years of age or younger was a protective factor against both skin cancers. Being a female and 70 years old or younger was a protective factor for basal cell carcinoma. A comparison of the frequencies of the VDR genotypes in patients older than 70 years vs. 70 years or younger also revealed age-dependent variations in patients with non-melanoma skin cancer. Our study suggests a role for VDR polymorphisms in non-melanoma skin cancer development.

scholarly journals Vitamin D enzymes (CYP27A1, CYP27B1, and CYP24A1) and receptor expression in non-melanoma skin cancer

2019 ◽  
Vol 51 (4) ◽  
pp. 444-447 ◽  
Author(s):  
Natalie Nemazannikova ◽  
Gregory L Blatch ◽  
Crispin R Dass ◽  
Rodney Sinclair ◽  
Vasso Apostolopoulos
Keyword(s):  
Vitamin D ◽  
Skin Cancer ◽  
Receptor Expression ◽  
Non Melanoma Skin Cancer ◽  
Melanoma Skin

scholarly journals Vitamin D and the Risk of Non-Melanoma Skin Cancer: A Systematic Literature Review and Meta-Analysis on Behalf of the Italian Melanoma Intergroup

Cancers ◽  
2021 ◽  
Vol 13 (19) ◽  
pp. 4815
Author(s):  
Saverio Caini ◽  
Patrizia Gnagnarella ◽  
Ignazio Stanganelli ◽  
Federica Bellerba ◽  
Emilia Cocorocchio ◽  
...  
Keyword(s):  
Vitamin D ◽  
Skin Cancer ◽  
Literature Review ◽  
Systematic Literature Review ◽  
Meta Analysis ◽  
Plasma Vitamin ◽  
Vitamin D Metabolism ◽  
Vitamin D Intake ◽  
Non Melanoma Skin Cancer ◽  
Melanoma Skin

We aimed to provide a comprehensive overview of the link between vitamin D and non-melanoma skin cancer (NMSC). For this purpose, we conducted a systematic literature review (updated to 3 February 2021) and meta-analysis of the studies reporting on the association between vitamin D intake (from diet and supplements) and blood concentration, polymorphisms of the vitamin D receptor (VDR) and vitamin D binding protein (VDBP) genes, and the risk of NMSC. Random effects meta-analysis models were fitted to merge study-specific risk estimates into summary relative risk (SRR) and corresponding 95% confidence intervals (CI). Twenty-four studies altogether were included. There was a suggestive association between increasing serum/plasma vitamin D concentration and NMSC risk (SRR for highest vs. lowest concentration 1.67, 95%CI 0.61–4.56), although with large heterogeneity across studies (I2 = 91%). NMSC risk was associated with highest vitamin D intake in observational studies but not in clinical trials. Finally, there was no significant association between any polymorphism of the VDR and VDBP genes and NMSC risk. In conclusion, no strong relationship between vitamin D metabolism and NMSC risk appears to exist according to our systematic review and meta-analysis, although some findings are worthy of further investigation.

scholarly journals Vitamin D serum levels and non-melanoma skin cancer risk

PeerJ ◽  
2021 ◽  
Vol 9 ◽  
pp. e12234
Author(s):  
Carolina Morgado-Águila ◽  
Guadalupe Gil-Fernández ◽  
Orlando Rafael Dávila-Villalobos ◽  
Jesús Pérez-Rey ◽  
Purificación Rey-Sánchez ◽  
...  
Keyword(s):  
Vitamin D ◽  
Skin Cancer ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Serum Vitamin D ◽  
Non Melanoma Skin Cancer ◽  
Skin Cancers ◽  
Vitamin D Levels ◽  
Age And Sex ◽  
Melanoma Skin

Background Skin cancer is one of the common malignancies. There is sufficient evidence that sunlight (ultraviolet radiation) contributes to the development of skin cancer, but there is also evidence that relates adequate serum levels of vitamin D produced on the skin by the action of ultraviolet radiation with the decreased risk of various types of cancers, including skin cancer. The aim of this study was to investigate the association of vitamin D serum levels among patients with non-melanoma skin cancers (basal cell carcinoma and squamous cell carcinoma) and controls. Methods A prospective observational case-control study was conducted in a sample of 84 subjects in Extremadura (Spain). Forty-one patients with histologically diagnosed basal cell carcinomas and squamous cell carcinomas and 43 healthy controls were randomly chosen to assess whether vitamin D (25(OH)D3) serum level, age and sex were related to non-melanoma skin cancer and to determine the possible risk of this type of skin cancer for these variables. Results When analysing serum vitamin D levels, we ensured that all our subjects, both cases and controls, had normal or low serum vitamin D levels, even though the samples were taken during months with the highest solar irradiance in our region. It is striking in our results that there was a higher percentage of subjects with deficits of vitamin D who did not have skin cancer (66%) than patients with deficits with these types of skin cancers (34%). When adjusting the model for age and sex, vitamin D values above 18 ng/ml increased the risk of suffering from non-melanoma skin cancer by nearly 7-fold (aOR: 6.94, 95% CI [1.55–31.11], p = 0.01). Conclusions Despite the controversial data obtained in the literature, our results suggest that lower levels of vitamin D may be related to a reduced incidence of non-melanoma skin cancer.

Vitamin D and melanoma and non-melanoma skin cancer risk and prognosis: A comprehensive review and meta-analysis

2014 ◽  
Vol 50 (15) ◽  
pp. 2649-2658 ◽  
Author(s):  
Saverio Caini ◽  
Mathieu Boniol ◽  
Giulio Tosti ◽  
Serena Magi ◽  
Matelda Medri ◽  
...  
Keyword(s):  
Vitamin D ◽  
Skin Cancer ◽  
Cancer Risk ◽  
Meta Analysis ◽  
Comprehensive Review ◽  
Skin Cancer Risk ◽  
Non Melanoma Skin Cancer ◽  
Melanoma Skin
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