scholarly journals Coordinating red cell differentiation with cell cycle arrest: GATA-1 activation of p21

Cell Cycle ◽  
2010 ◽  
Vol 9 (11) ◽  
pp. 2059-2062 ◽  
Author(s):  
Adam N. Goldfarb
Keyword(s):  
Cell Cycle ◽  
Cell Differentiation ◽  
Cell Cycle Arrest ◽  
Red Cell ◽  
Cycle Arrest

scholarly journals Silencing of miR-124 induces neuroblastoma SK-N-SH cell differentiation, cell cycle arrest and apoptosis through promoting AHR

FEBS Letters ◽  
2011 ◽  
Vol 585 (22) ◽  
pp. 3582-3586 ◽  
Author(s):  
Tsui-Chin Huang ◽  
Hsin-Yi Chang ◽  
Cheng-Yu Chen ◽  
Pei-Yi Wu ◽  
Hsinyu Lee ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Differentiation ◽  
Cell Cycle Arrest ◽  
Cycle Arrest

scholarly journals Icariin induces cell differentiation and cell cycle arrest in mouse melanoma B16 cells via Erk1/2-p38-JNK-dependent pathway

Oncotarget ◽  
2017 ◽  
Vol 8 (59) ◽  
pp. 99504-99513 ◽  
Author(s):  
Dan Wang ◽  
Wenjuan Xu ◽  
Xiaoyu Chen ◽  
Jichun Han ◽  
Lina Yu ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Differentiation ◽  
Cell Cycle Arrest ◽  
Mouse Melanoma ◽  
Melanoma B16 ◽  
Cycle Arrest ◽  
Dependent Pathway

The potential role of ribosomal protein S5 on cell cycle arrest and initiation of murine erythroleukemia cell differentiation

2008 ◽  
Vol 104 (4) ◽  
pp. 1477-1490 ◽  
Author(s):  
Christina N. Matragkou ◽  
Eleni T. Papachristou ◽  
Sotirios S. Tezias ◽  
Asterios S. Tsiftsoglou ◽  
Theodora Choli‐Papadopoulou ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Differentiation ◽  
Ribosomal Protein ◽  
Cell Cycle Arrest ◽  
Potential Role ◽  
Cycle Arrest ◽  
Erythroleukemia Cell ◽  
Murine Erythroleukemia ◽  
Murine Erythroleukemia Cell

scholarly journals Induction of p18INK4c and its predominant association with CDK4 and CDK6 during myogenic differentiation.

1996 ◽  
Vol 7 (10) ◽  
pp. 1587-1599 ◽  
Author(s):  
D S Franklin ◽  
Y Xiong
Keyword(s):  
Cell Cycle ◽  
Cell Differentiation ◽  
Cell Cycle Arrest ◽  
Kinase Activity ◽  
Myogenic Differentiation ◽  
Critical Role ◽  
C2c12 Cells ◽  
C2c12 Myoblast ◽  
Mouse Muscle ◽  
Cycle Arrest

Terminal cell differentiation involves permanent withdrawal from the cell division cycle. The inhibitors of cyclin-dependent kinases (CDKs) are potential molecules functioning to couple cell cycle arrest and cell differentiation. In murine C2C12 myoblast cells, G1 CDK enzymes (CDK2, CDK4, and CDK6) associate with four CDK inhibitors: p18INK4c, p19INK4d, p21, and p27Kip1. During induced myogenesis, p21 and its associated CDK proteins underwent an initial increase followed by a decrease as cells became terminally differentiated. The level of p27 protein gradually increased, but the amount of total associated CDK proteins remained unchanged. p19 protein decreased gradually during differentiation, as did its associated CDK4 protein. In contrast, p18 protein increased 50-fold, from negligible levels in proliferating myoblasts to clearly detectable levels within 8-12 h of myogenic induction. This initial rise was followed by a precipitous increase between 12 and 24 h postinduction, with p18 protein finally accumulating to its highest level in terminally differentiated cells. Induction of p18 correlated with increased and sequential complex formation--first increasing association with CDK6 and then with CDK4 over the course of myogenic differentiation. All of the CDK6 and half of the CDK4 were complexed with p18 in terminally differentiated C2C12 cells as well as in adult mouse muscle tissue. Finally, kinase activity of CDK2 and CDK4 decreases as C2C12 cells differentiate, whereas the CDK6 kinase activity is low in both proliferating myoblasts and differentiated myotubes. Our results indicate that p18 may play a critical role in causing and/or maintaining permanent cell cycle arrest associated with mature muscle formation.

Apoptosis during HL-60 cell differentiation is closely related to a G0/G1 cell cycle arrest

1995 ◽  
Vol 164 (1) ◽  
pp. 74-84 ◽  
Author(s):  
Yasuhito Terui ◽  
Yusuke Furukawa ◽  
Jiro Kikuchi ◽  
Masaki Saito
Keyword(s):  
Cell Cycle ◽  
Cell Differentiation ◽  
Cell Cycle Arrest ◽  
Cycle Arrest ◽  
G1 Cell Cycle Arrest
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