scholarly journals MicroRNA-145 in vascular smooth muscle cell biology: A new therapeutic target for vascular disease

Cell Cycle ◽  
2009 ◽  
Vol 8 (21) ◽  
pp. 3469-3473 ◽  
Author(s):  
Chunxiang Zhang
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Vascular Disease ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Therapeutic Target ◽  
Cell Biology

Vascular smooth muscle cell proliferation as a therapeutic target. Part 1: molecular targets and pathways

2018 ◽  
Vol 36 (6) ◽  
pp. 1586-1607 ◽  
Author(s):  
Dongdong Wang ◽  
Pavel Uhrin ◽  
Andrei Mocan ◽  
Birgit Waltenberger ◽  
Johannes M. Breuss ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Therapeutic Target ◽  
Molecular Targets ◽  
Smooth Muscle Cell Proliferation

scholarly journals Protective role of vascular smooth muscle cell PPARγ in angiotensin II-induced vascular disease

2012 ◽  
Vol 97 (3) ◽  
pp. 562-570 ◽  
Author(s):  
Chiara Marchesi ◽  
Asia Rehman ◽  
Yohann Rautureau ◽  
Daniel A. Kasal ◽  
Marie Briet ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Angiotensin Ii ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Vascular Disease ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Protective Role

Abstract 95: MiRNA-210 Enhances Fibrous Cap Stability in Advanced Atherosclerotic Lesions

2017 ◽  
Vol 37 (suppl_1) ◽  
Author(s):  
Suzanne M Eken ◽  
Hong Jin ◽  
Ekaterina Chernogubova ◽  
Yuhuang Li ◽  
Nancy Simon ◽  
...  
Keyword(s):  
At Risk ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Cell Survival ◽  
Vascular Disease ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Fibrous Cap ◽  
Atherosclerotic Lesions

In the search for markers and modulators of vascular disease, miRNAs have emerged as potent therapeutic targets. We investigated miRNAs of clinical interest in patients with unstable carotid stenosis at risk of stroke. Utilizing patient material from the Biobank of Karolinska Endarterectomies (BiKE), we profiled miRNA expression in symptomatic versus asymptomatic patients with high-grade carotid artery stenosis. A PCR-based miRNA of plasma, sampled at the carotid lesion site, identified eight deregulated miRNAs (miR-15b, -29c, -30c/d, -150, -191, -210 and -500). miR-210 was the most significantly downregulated miRNA in local plasma material. Laser-capture microdissection as well as in situ hybridization revealed a distinct localization of miR-210 in the fibrous caps of atherosclerotic lesions and showed reduced miR-210 expression in the unstable fibrous cap. We confirmed that miR-210 directly targets the tumor suppressor gene adenomatous polyposis coli (APC), thereby affecting Wnt signaling and regulating vascular smooth muscle cell survival, as well as differentiation, in advanced atherosclerotic lesions. Substantial changes in arterial miR-210 were detectable in two rodent models of vascular remodeling and plaque rupture. Modulating miR-210 in vitro and in vivo improved fibrous cap stability with implications for vascular disease. We discovered that an unstable carotid plaque at risk of stroke is characterized by low expression of miR-210. miR-210 contributes to stabilizing carotid plaques through inhibition of APC, ensuring vascular smooth muscle cell survival. We present local delivery of miR-210 as a therapeutic approach for prevention of atherothrombotic disease.

scholarly journals DNA glycosylase Neil3 regulates vascular smooth muscle cell biology during atherosclerosis development

2021 ◽  
Author(s):  
Ana Quiles-Jiménez ◽  
Ida Gregersen ◽  
Filip M. Segers ◽  
Tonje Skarpengland ◽  
Penelope Kroustallaki ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Cell Biology ◽  
Dna Glycosylase ◽  
Atherosclerosis Development
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