scholarly journals Fbxw7 in cell cycle exit and stem cell maintenance: Insight from gene-targeted mice

Cell Cycle ◽  
2008 ◽  
Vol 7 (21) ◽  
pp. 3307-3313 ◽  
Author(s):  
Ichiro Onoyama ◽  
Keiichi I. Nakayama
Keyword(s):  
Cell Cycle ◽  
Stem Cell ◽  
Cell Cycle Exit ◽  
Stem Cell Maintenance ◽  
Cell Maintenance

scholarly journals Regulation of KAT6 Acetyltransferases and Their Roles in Cell Cycle Progression, Stem Cell Maintenance, and Human Disease

2016 ◽  
Vol 36 (14) ◽  
pp. 1900-1907 ◽  
Author(s):  
Fu Huang ◽  
Susan M. Abmayr ◽  
Jerry L. Workman
Keyword(s):  
Cell Cycle ◽  
Stem Cell ◽  
Cell Cycle Progression ◽  
Histone Acetyltransferase ◽  
Regulatory Mechanisms ◽  
Cycle Progression ◽  
Stem Cell Maintenance ◽  
Lysine Acetyltransferase ◽  
Cycle Regulation ◽  
Cell Maintenance

The lysine acetyltransferase 6 (KAT6) histone acetyltransferase (HAT) complexes are highly conserved from yeast to higher organisms. They acetylate histone H3 and other nonhistone substrates and are involved in cell cycle regulation and stem cell maintenance. In addition, the human KAT6 HATs are recurrently mutated in leukemia and solid tumors. Therefore, it is important to understand the mechanisms underlying the regulation of KAT6 HATs and their roles in cell cycle progression. In this minireview, we summarize the identification and analysis of the KAT6 complexes and discuss the regulatory mechanisms governing their enzymatic activities and substrate specificities. We further focus on the roles of KAT6 HATs in regulating cell proliferation and stem cell maintenance and review recent insights that aid in understanding their involvement in human diseases.

Abstract 2621: OLIG2 regulates stem cell maintenance and cell cycle in glioma stem cells

2019 ◽  
Author(s):  
Norihiko Saito ◽  
Nozomi Hirai ◽  
Kazuya Aoki ◽  
Satoshi Fujita ◽  
Haruo Nakayama ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Stem Cells ◽  
Stem Cell ◽  
Glioma Stem Cells ◽  
Stem Cell Maintenance ◽  
Cell Maintenance

Abstract 2621: OLIG2 regulates stem cell maintenance and cell cycle in glioma stem cells

2019 ◽  
Author(s):  
Norihiko Saito ◽  
Nozomi Hirai ◽  
Kazuya Aoki ◽  
Satoshi Fujita ◽  
Haruo Nakayama ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Stem Cells ◽  
Stem Cell ◽  
Glioma Stem Cells ◽  
Stem Cell Maintenance ◽  
Cell Maintenance

miR-146a regulates hematopoietic stem cell maintenance and cell cycle entry

2013 ◽  
Vol 41 (8) ◽  
pp. S17
Author(s):  
Joanna Wegrzyn Woltosz ◽  
David Knapp ◽  
Michael Copley ◽  
Rawa Ibrahim ◽  
Patricia Umlandt ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Hematopoietic Stem ◽  
Stem Cell Maintenance ◽  
Cell Cycle Entry ◽  
Cell Maintenance

scholarly journals ETMR-19. SINGLE CELL ANALYSES OF ETMRs REVEAL THAT C19MC+ POPULATION DRIVES CELL CYCLE PROGRESSION AND STEM CELL MAINTENANCE

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii326-iii327
Author(s):  
Iqra Mumal ◽  
Liming Xu ◽  
Fupan Yao ◽  
Tannu Suwal ◽  
Xiaolian Fan ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Stem Cell ◽  
Single Cell ◽  
Stem Cell Population ◽  
Significant Heterogeneity ◽  
Mirna Cluster ◽  
Direct Role ◽  
Stem Cell Maintenance ◽  
Molecular Features ◽  
Cell Maintenance

Abstract Embryonal tumors with multilayered rosettes (ETMRs) are highly fatal diseases characterized by recurrent amplification of C19MC, an oncogenic miRNA cluster. While C19MC was discovered as a major driver of ETMRs, its direct role in ETMRs remains unknown. As ETMRs exhibit significant heterogeneity in C19MC expression, we employed single cell transcriptomics to investigate features of C19MC+ population. We conducted single-nuclei RNAseq of 23,269 cells from 6 primary and 2 matched recurrent ETMRs. We also conducted single-cell RNAseq of human neural stem cells (hNSC-5miR) and ETMR cell line (A664-5miR) with stable expression of 5 C19MC miRNAs. Bulk RNAseq (n=27), H3K27Ac ChiP-seq (n=5) and ATAC-seq (n=5) corroborated scRNAseq data and identified core transcription factors (TFs) of C19MC+ population. C19MC+ population (24%) mapped to neuro-epithelial cells and exhibited signatures of cell cycle and stem cell maintenance, consistent with bulk-RNAseq data. The C19MC+ population overlaps with MKI67+ cycling (57%) and PROM1+ stem cell population (56%). Interestingly, interrogation of hNSC-5mir and A664-5miR showed a larger MKI67+/PROM1+ population compared to controls. Likewise, hNSC-5miR/A664-5miR in vitro and in vivo experiments showed increased proliferation/stemness. C19MC+ population is characterized by SHH, WNT, mTOR, Hippo and IGF-signalling and driven by MEIS1, SOX11, ZNF521, RFX4 and NR2F2 TFs. Recurrent ETMRs exhibit a persistent but smaller C19MC+ population. Intriguingly, recurrent tumors were more quiescent with a smaller proliferative population. C19MC is directly involved in driving cell cycle and stemness in ETMRs. Cellular and molecular features of primary and recurrent ETMRs were remarkably different, suggesting that C19MC plays a different role upon recurrence.

scholarly journals Ezh1 Is Required for Hematopoietic Stem Cell Maintenance and Prevents Senescence-like Cell Cycle Arrest

2012 ◽  
Vol 11 (5) ◽  
pp. 649-662 ◽  
Author(s):  
Isabel Hidalgo ◽  
Antonio Herrera-Merchan ◽  
Jose Manuel Ligos ◽  
Laura Carramolino ◽  
Javier Nuñez ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Stem Cell ◽  
Cell Cycle Arrest ◽  
Hematopoietic Stem Cell ◽  
Hematopoietic Stem ◽  
Stem Cell Maintenance ◽  
Cycle Arrest ◽  
Cell Maintenance

scholarly journals Cell-cycle quiescence maintains Caenorhabditis elegans germline stem cells independent of GLP-1/Notch

eLife ◽  
2015 ◽  
Vol 4 ◽  
Author(s):  
Hannah S Seidel ◽  
Judith Kimble
Keyword(s):  
Cell Cycle ◽  
Stem Cells ◽  
Stem Cell ◽  
Caenorhabditis Elegans ◽  
Signaling Pathway ◽  
Adult Stem Cells ◽  
Germline Stem Cells ◽  
Stem Cell Maintenance ◽  
M Phase ◽  
Cell Maintenance

Many types of adult stem cells exist in a state of cell-cycle quiescence, yet it has remained unclear whether quiescence plays a role in maintaining the stem cell fate. Here we establish the adult germline of Caenorhabditis elegans as a model for facultative stem cell quiescence. We find that mitotically dividing germ cells—including germline stem cells—become quiescent in the absence of food. This quiescence is characterized by a slowing of S phase, a block to M-phase entry, and the ability to re-enter M phase rapidly in response to re-feeding. Further, we demonstrate that cell-cycle quiescence alters the genetic requirements for stem cell maintenance: The signaling pathway required for stem cell maintenance under fed conditions—GLP-1/Notch signaling—becomes dispensable under conditions of quiescence. Thus, cell-cycle quiescence can itself maintain stem cells, independent of the signaling pathway otherwise essential for such maintenance.

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