scholarly journals Antisense Knockdown of Cyclin E does not affect the Midblastula Transition in Xenopus laevis Embryos

Cell Cycle ◽  
2005 ◽  
Vol 4 (10) ◽  
pp. 1396-1402 ◽  
Author(s):  
Michael K. Slevin ◽  
Gillian Lyons-Levy ◽  
Daniel L. Weeks ◽  
Rebecca S. Hartley
Keyword(s):  
Xenopus Laevis ◽  
Cyclin E ◽  
Midblastula Transition ◽  
Antisense Knockdown ◽  
Xenopus Laevis Embryos

scholarly journals Quantum dot assisted tracking of the intracellular protein Cyclin E in Xenopus laevis embryos

2015 ◽  
Vol 13 (1) ◽  
Author(s):  
Yekaterina I Brandt ◽  
Therese Mitchell ◽  
Gennady A Smolyakov ◽  
Marek Osiński ◽  
Rebecca S Hartley
Keyword(s):  
Quantum Dot ◽  
Xenopus Laevis ◽  
Cyclin E ◽  
Intracellular Protein ◽  
Xenopus Laevis Embryos

Quantum dot assisted tracking of the intracellular protein Cyclin E in Xenopus laevis embryos

nano Online ◽  
2016 ◽  
Author(s):  
Yekaterina I Brandt ◽  
Therese Mitchell ◽  
Gennady A Smolyakov ◽  
Marek Osiński ◽  
Rebecca S Hartley
Keyword(s):  
Quantum Dot ◽  
Xenopus Laevis ◽  
Cyclin E ◽  
Intracellular Protein ◽  
Xenopus Laevis Embryos

scholarly journals Altering nuclear import in early Xenopus laevis embryos affects later development

2019 ◽  
Author(s):  
Predrag Jevtić ◽  
Daniel L. Levy
Keyword(s):  
Xenopus Laevis ◽  
Nuclear Import ◽  
Cell Number ◽  
Early Embryo ◽  
Cellular Functions ◽  
Midblastula Transition ◽  
Developmental Progression ◽  
Importin Α ◽  
Xenopus Laevis Embryos ◽  
Downstream Development

ABSTRACTMore than just a container for DNA, the nucleus carries out a wide variety of critical and highly regulated cellular functions. One of these functions is nuclear import, and in this study we investigate how altering nuclear import impacts developmental progression and organismal size. During early Xenopus laevis embryogenesis, the timing of a key developmental event, the midblastula transition (MBT), is sensitive to nuclear import factor levels. How might altering nuclear import and MBT timing in the early embryo affect downstream development of the organism? We microinjected X.laevis two-cell embryos to increase levels of importin α or NTF2, resulting in differential amounts of nuclear import factors in the two halves of the embryo. Compared to controls, these embryos exhibited delayed gastrulation, curved neural plates, and bent tadpoles with different sized eyes. Furthermore, embryos microinjected with NTF2 developed into smaller froglets compared to control microinjected embryos. We propose that altering nuclear import and size affects MBT timing, cell size, and cell number, subsequently disrupting later development. Thus, altering nuclear import early in development can affect function and size at the organismal level.

A kinetic model of the cyclin E/Cdk2 developmental timer in Xenopus laevis embryos

2003 ◽  
Vol 104 (3) ◽  
pp. 573-589 ◽  
Author(s):  
Andrea Ciliberto ◽  
Matthew J Petrus ◽  
John J Tyson ◽  
Jill C Sible
Keyword(s):  
Kinetic Model ◽  
Xenopus Laevis ◽  
Cyclin E ◽  
Xenopus Laevis Embryos

scholarly journals Iron nanoparticle bio-interactions evaluated in Xenopus laevis embryos, a model for studying the safety of ingested nanoparticles

2019 ◽  
Vol 14 (2) ◽  
pp. 196-213
Author(s):  
Patrizia Bonfanti ◽  
Anita Colombo ◽  
Melissa Saibene ◽  
Luisa Fiandra ◽  
Ilaria Armenia ◽  
...  
Keyword(s):  
Xenopus Laevis ◽  
Iron Nanoparticle ◽  
Xenopus Laevis Embryos ◽  
Ingested Nanoparticles
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