scholarly journals Npl3, a new link between RNA-binding proteins and the maintenance of genome integrity

Cell Cycle ◽  
2014 ◽  
Vol 13 (10) ◽  
pp. 1524-1529 ◽  
Author(s):  
José M Santos-Pereira ◽  
Ana B Herrero ◽  
Sergio Moreno ◽  
Andrés Aguilera
Keyword(s):  
Binding Proteins ◽  
Rna Binding ◽  
Rna Binding Proteins ◽  
Genome Integrity

scholarly journals RNA Binding Proteins and Genome Integrity

2017 ◽  
Vol 18 (7) ◽  
pp. 1341 ◽  
Author(s):  
Kensei Nishida ◽  
Yuki Kuwano ◽  
Tatsuya Nishikawa ◽  
Kiyoshi Masuda ◽  
Kazuhito Rokutan
Keyword(s):  
Binding Proteins ◽  
Rna Binding ◽  
Rna Binding Proteins ◽  
Genome Integrity

scholarly journals AU-Rich Element RNA Binding Proteins: At the Crossroads of Post-Transcriptional Regulation and Genome Integrity

2021 ◽  
Vol 23 (1) ◽  
pp. 96
Author(s):  
Ahmed Sidali ◽  
Varsha Teotia ◽  
Nadeen Shaikh Solaiman ◽  
Nahida Bashir ◽  
Radhakrishnan Kanagaraj ◽  
...  
Keyword(s):  
Dna Damage ◽  
Cellular Localization ◽  
Binding Proteins ◽  
Rna Binding ◽  
Rna Binding Proteins ◽  
Genome Integrity ◽  
Genome Maintenance ◽  
Cellular Survival ◽  
Novel Therapeutic Strategies ◽  
Post Transcriptional Regulation

Genome integrity must be tightly preserved to ensure cellular survival and to deter the genesis of disease. Endogenous and exogenous stressors that impose threats to genomic stability through DNA damage are counteracted by a tightly regulated DNA damage response (DDR). RNA binding proteins (RBPs) are emerging as regulators and mediators of diverse biological processes. Specifically, RBPs that bind to adenine uridine (AU)-rich elements (AREs) in the 3′ untranslated region (UTR) of mRNAs (AU-RBPs) have emerged as key players in regulating the DDR and preserving genome integrity. Here we review eight established AU-RBPs (AUF1, HuR, KHSRP, TIA-1, TIAR, ZFP36, ZFP36L1, ZFP36L2) and their ability to maintain genome integrity through various interactions. We have reviewed canonical roles of AU-RBPs in regulating the fate of mRNA transcripts encoding DDR genes at multiple post-transcriptional levels. We have also attempted to shed light on non-canonical roles of AU-RBPs exploring their post-translational modifications (PTMs) and sub-cellular localization in response to genotoxic stresses by various factors involved in DDR and genome maintenance. Dysfunctional AU-RBPs have been increasingly found to be associated with many human cancers. Further understanding of the roles of AU-RBPS in maintaining genomic integrity may uncover novel therapeutic strategies for cancer.

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