scholarly journals Knockdown of astrocyte elevated gene-1 (AEG-1) in cervical cancer cells decreases their invasiveness, epithelial to mesenchymal transition, and chemoresistance

Cell Cycle ◽  
2014 ◽  
Vol 13 (11) ◽  
pp. 1702-1707 ◽  
Author(s):  
Xiangwen Liu ◽  
Degui Wang ◽  
Huiling Liu ◽  
Ying Feng ◽  
Tianyuan Zhu ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Cells ◽  
Epithelial To Mesenchymal Transition ◽  
Mesenchymal Transition ◽  
Cervical Cancer Cells

hCINAP is a potential direct HIF-1 target gene and is required for hypoxia-induced EMT and apoptosis in cervical cancer cells

2020 ◽  
Author(s):  
yong zhang ◽  
li jiang ◽  
nianqun qin ◽  
Mi Cao ◽  
xiujuan Liang ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Cells ◽  
Target Gene ◽  
Epithelial To Mesenchymal Transition ◽  
Critical Role ◽  
Surrounding Tissue ◽  
Mesenchymal Transition ◽  
Migratory Capacity ◽  
Signal Input ◽  
Cervical Cancer Cells

The early metastasis of cervical cancer is a multi-step process requiring the cancer cells to adapt to the signal input from different tissue environments, including hypoxia. Hypoxia-induced epithelial-to-mesenchymal transition (EMT) plays a critical role in the acquisition of the ability to invade surrounding tissue. However, the molecular mechanism underlying EMT in cervical cancer remains to be elucidated. Herein, we showed that HIF‑1α and ARNT are recruited to the hCINAP promoter and initiate hCINAP expression in hypoxia. Ablation of hCINAP decreased the migratory capacity and EMT of cervical cancer cells in hypoxia. Furthermore, hCINAP regulates EMT through Akt/mTOR signaling and inhibits hypoxia-induced p53-dependent apoptosis. Our data collectively showed that hCINAP may have essential roles in the metastasis of cervical cancer and could be a potential target for curing cervical cancer.

scholarly journals HOXA9 is Underexpressed in Cervical Cancer Cells and its Restoration Decreases Proliferation, Migration and Expression of Epithelial-to-Mesenchymal Transition Genes

2016 ◽  
Vol 17 (3) ◽  
pp. 1037-1047 ◽  
Author(s):  
Liliana Alvarado-Ruiz ◽  
Maria Guadalupe Martinez-Silva ◽  
Luis Alberto Torres-Reyes ◽  
Patricia Pina-Sanchez ◽  
Pablo Ortiz-Lazareno ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Cells ◽  
Epithelial To Mesenchymal Transition ◽  
Mesenchymal Transition ◽  
Cervical Cancer Cells
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