scholarly journals microRNA-17~92 is a powerful cancer driver and a therapeutic target

Cell Cycle ◽  
2014 ◽  
Vol 13 (4) ◽  
pp. 495-496 ◽  
Author(s):  
Hyun Yong Jin ◽  
Maoyi Lai ◽  
Changchun Xiao
Keyword(s):  
Therapeutic Target ◽  
Cancer Driver

Memapsin 2, a drug target for Alzheimer's disease

2003 ◽  
Vol 70 ◽  
pp. 213-220 ◽  
Author(s):  
Gerald Koelsch ◽  
Robert T. Turner ◽  
Lin Hong ◽  
Arun K. Ghosh ◽  
Jordan Tang
Keyword(s):  
Crystal Structure ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Transition State ◽  
Amyloid Precursor Protein ◽  
Therapeutic Target ◽  
Drug Target ◽  
Aspartic Protease ◽  
Precursor Protein ◽  
Memapsin 2

Mempasin 2, a ϐ-secretase, is the membrane-anchored aspartic protease that initiates the cleavage of amyloid precursor protein leading to the production of ϐ-amyloid and the onset of Alzheimer's disease. Thus memapsin 2 is a major therapeutic target for the development of inhibitor drugs for the disease. Many biochemical tools, such as the specificity and crystal structure, have been established and have led to the design of potent and relatively small transition-state inhibitors. Although developing a clinically viable mempasin 2 inhibitor remains challenging, progress to date renders hope that memapsin 2 inhibitors may ultimately be useful for therapeutic reduction of ϐ-amyloid.

COX–2 is overesxpressed in ovarian endometriosis and might represent a therapeutic target

2008 ◽  
Vol 68 (S 01) ◽  
Author(s):  
A Meinel ◽  
C Leo ◽  
G Zimmermann ◽  
H Alexander ◽  
LC Horn
Keyword(s):  
Therapeutic Target ◽  
Ovarian Endometriosis ◽  
Cox 2

Investigation of BRAF fusion genes as a therapeutic target in pilocytic astrocytoma

2012 ◽  
Vol 224 (06) ◽  
Author(s):  
H Cin ◽  
J Gronych ◽  
A Korshunov ◽  
DTW Jones ◽  
D Milford ◽  
...  
Keyword(s):  
Pilocytic Astrocytoma ◽  
Therapeutic Target ◽  
Fusion Genes ◽  
Braf Fusion
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