scholarly journals Nek9 regulates spindle organization and cell cycle progression during mouse oocyte meiosis and its location in early embryo mitosis

Cell Cycle ◽  
2012 ◽  
Vol 11 (23) ◽  
pp. 4366-4377 ◽  
Author(s):  
Shang-Wu Yang ◽  
Chen Gao ◽  
Lei Chen ◽  
Ya-Li Song ◽  
Jin-Liang Zhu ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Progression ◽  
Early Embryo ◽  
Mouse Oocyte ◽  
Cycle Progression ◽  
Oocyte Meiosis

scholarly journals Chk2 Regulates Cell Cycle Progression during Mouse Oocyte Maturation and Early Embryo Development

2014 ◽  
Vol 37 (2) ◽  
pp. 126-132 ◽  
Author(s):  
Xiao-Xin Dai ◽  
Xing Duan ◽  
Hong-Lin Liu ◽  
Xiang-Shun Cui ◽  
Nam-Hyung Kim ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Embryo Development ◽  
Oocyte Maturation ◽  
Cell Cycle Progression ◽  
Early Embryo ◽  
Mouse Oocyte ◽  
Cycle Progression ◽  
Early Embryo Development

scholarly journals CNOT 6L couples the selective degradation of maternal transcripts to meiotic cell cycle progression in mouse oocyte

2018 ◽  
Vol 37 (24) ◽  
Author(s):  
Qian‐Qian Sha ◽  
Jia‐Li Yu ◽  
Jing‐Xin Guo ◽  
Xing‐Xing Dai ◽  
Jun‐Chao Jiang ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Progression ◽  
Mouse Oocyte ◽  
Meiotic Cell ◽  
Cycle Progression ◽  
Selective Degradation ◽  
Maternal Transcripts

scholarly journals Ca2+cyt negatively regulates the initiation of oocyte maturation

2004 ◽  
Vol 165 (1) ◽  
pp. 63-75 ◽  
Author(s):  
Lu Sun ◽  
Khaled Machaca
Keyword(s):  
Cell Cycle ◽  
Oocyte Maturation ◽  
Cell Cycle Progression ◽  
Germinal Vesicle ◽  
Germinal Vesicle Breakdown ◽  
Cycle Progression ◽  
Nuclear Maturation ◽  
Oocyte Meiosis ◽  
Kinase Cascade ◽  
Cell Cycle Machinery

Ca2+ is a ubiquitous intracellular messenger that is important for cell cycle progression. Genetic and biochemical evidence support a role for Ca2+ in mitosis. In contrast, there has been a long-standing debate as to whether Ca2+ signals are required for oocyte meiosis. Here, we show that cytoplasmic Ca2+ (Ca2+cyt) plays a dual role during Xenopus oocyte maturation. Ca2+ signals are dispensable for meiosis entry (germinal vesicle breakdown and chromosome condensation), but are required for the completion of meiosis I. Interestingly, in the absence of Ca2+cyt signals oocytes enter meiosis more rapidly due to faster activation of the MAPK-maturation promoting factor (MPF) kinase cascade. This Ca2+-dependent negative regulation of the cell cycle machinery (MAPK-MPF cascade) is due to Ca2+cyt acting downstream of protein kinase A but upstream of Mos (a MAPK kinase kinase). Therefore, high Ca2+cyt delays meiosis entry by negatively regulating the initiation of the MAPK-MPF cascade. These results show that Ca2+ modulates both the cell cycle machinery and nuclear maturation during meiosis.

A casein kinase I isoform is required for proper cell cycle progression in the fertilized mouse oocyte

1997 ◽  
Vol 110 (24) ◽  
pp. 3083-3090 ◽  
Author(s):  
S.D. Gross ◽  
C. Simerly ◽  
G. Schatten ◽  
R.A. Anderson
Keyword(s):  
Cell Cycle ◽  
Subcellular Localization ◽  
Mammalian Cells ◽  
Cell Cycle Progression ◽  
T Antigen ◽  
Casein Kinase ◽  
Mouse Oocyte ◽  
Casein Kinase I ◽  
Sv40 Large T Antigen ◽  
Cycle Progression

Casein kinase I is a family of serine/threonine protein kinases common to all eukaryotes. In yeast, casein kinase I homologues have been linked to the regulation of growth, DNA repair and cell division. In addition, their subcellular localization to membraneous structures and the nucleus is essential for function. In higher eukaryotes, there exist seven genetically distinct isoforms: (alpha), ss, (gamma)1, (gamma)2, (gamma)3, (delta) and (epsilon). Casein kinase I(alpha) exhibits a cell cycle-dependent subcellular localization including an association with cytosolic vesicular structures and the nucleus during interphase, and the spindle during mitosis. casein kinase I has also been shown to modulate critical regulators of growth and DNA synthesis/repair in mammalian cells such as SV40 large T antigen and p53. These results suggest that casein kinase I may be involved in processes similar to those ascribed to the yeast casein kinase I homologues. To define a role for casein kinase I(alpha) in cell cycle regulation, the mouse oocyte was utilized because of its well-defined cell cycle and ease of micromanipulation. Immunofluorescence studies from meiosis I of maturation to the first zygotic cleavage demonstrated that the kinase was associated with structures similar to those previously reported. Microinjection of casein kinase I(alpha) antibodies at metaphase II-arrest and G2 phase, had no effect on the completion of second meiosis or first division. However, microinjection of these antibodies during the early pronucleate phase prior to S-phase onset blocked uptake of the kinase into pronuclei and interfered with proper and timely cell cycle progression to first cleavage. These results suggest that the kinase regulates the progression from interphase to mitosis during the first cell cycle.

scholarly journals miR-92a-3p controls cell cycle progression in zebrafish

2019 ◽  
Author(s):  
Christopher E. Presslauer ◽  
Teshome T. Bizuayehu ◽  
Jorge M.O. Fernandes ◽  
Igor S. Babiak
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Progression ◽  
Protein Tyrosine Kinase ◽  
Gonadal Development ◽  
Early Embryo ◽  
Cyclin Dependent Kinase ◽  
Cell Stage ◽  
Cycle Progression ◽  
Early Stages ◽  
Micro Rnas

AbstractBiological functions of micro RNAs (miRNAs) in the early stages of vertebrate development remain largely unknown. In zebrafish, miRNA miR-92a-3p is abundant in the germ cells throughout gonadal development, as well as in ovulated oocytes. Previously, we demonstrated that inhibition of miR-92a-3p in mature ovaries resulted in developmental arrest at the 1-cell stage upon fertilization of the affected oocytes. This suggested functions of miR-92a-3p in early development. In the present study, we identified wee2, an oocyte-specific protein tyrosine kinase, as a target of maternal miR-92a-3p during the early stages of zebrafish embryogenesis. Spatiotemporal co-presence of both miR-92a-3p and wee2 during early embryo development was confirmed by absolute quantification and in situ hybridization. Targeted knockdown of miR-92a-3p in embryos resulted in retarded embryonic development over the first 24 hours. Target validation assays demonstrated that miR-92a-3p interacted with the predicted wee2 3’UTR binding site, which was strongly suppressed by endogenous miR-92a-3p. Our results suggest that miR-92a-3p regulates the abundance of wee2, a cyclin-dependent kinase 1 inhibitor, thus having important role in regulation of the cell cycle during cleavage stages in zebrafish.Summary statementIn zebrafish, maternal miR-92a-3p was demonstrated to suppress translation of wee2, a cyclin-dependent kinase 1 inhibitor which regulates cell cycle progression during the early stages of embryogenesis.

NEK5 regulates cell cycle progression during mouse oocyte maturation and preimplantation embryonic development

2019 ◽  
Vol 86 (9) ◽  
pp. 1189-1198 ◽  
Author(s):  
Yuan‐Yuan Li ◽  
Lei Guo ◽  
Hui Li ◽  
Jian Li ◽  
Feng Dong ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Embryonic Development ◽  
Oocyte Maturation ◽  
Cell Cycle Progression ◽  
Mouse Oocyte ◽  
Cycle Progression
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