scholarly journals Multiple Roles of the PI3K/PKB (Akt) Pathway in Cell Cycle Progression

Cell Cycle ◽  
2003 ◽  
Vol 2 (4) ◽  
pp. 336-342 ◽  
Author(s):  
Jiyong Liang ◽  
Joyce M. Slingerland
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Progression ◽  
Multiple Roles ◽  
Akt Pathway ◽  
Cycle Progression

scholarly journals The Multiple Roles of the Cdc14 Phosphatase in Cell Cycle Control

2020 ◽  
Vol 21 (3) ◽  
pp. 709
Author(s):  
Javier Manzano-López ◽  
Fernando Monje-Casas
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Progression ◽  
Current Knowledge ◽  
Cell Cycle Control ◽  
Multiple Roles ◽  
Special Focus ◽  
Cyclin Dependent Kinase ◽  
Yeast Saccharomyces Cerevisiae ◽  
Cycle Progression

The Cdc14 phosphatase is a key regulator of mitosis in the budding yeast Saccharomyces cerevisiae. Cdc14 was initially described as playing an essential role in the control of cell cycle progression by promoting mitotic exit on the basis of its capacity to counteract the activity of the cyclin-dependent kinase Cdc28/Cdk1. A compiling body of evidence, however, has later demonstrated that this phosphatase plays other multiple roles in the regulation of mitosis at different cell cycle stages. Here, we summarize our current knowledge about the pivotal role of Cdc14 in cell cycle control, with a special focus in the most recently uncovered functions of the phosphatase.

scholarly journals Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy

Leukemia ◽  
2003 ◽  
Vol 17 (3) ◽  
pp. 590-603 ◽  
Author(s):  
F Chang ◽  
J T Lee ◽  
P M Navolanic ◽  
L S Steelman ◽  
J G Shelton ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cancer Chemotherapy ◽  
Cell Cycle Progression ◽  
Neoplastic Transformation ◽  
Akt Pathway ◽  
Cycle Progression

scholarly journals LncRNA UCA1 elevates the resistance of human leukaemia cells to daunorubicin by the PI3K/AKT pathway via sponging miR-613

2021 ◽  
Author(s):  
Qiying Yao ◽  
Li Zhang ◽  
Yuchuan Wang ◽  
Junli Liu ◽  
Liu Yang ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Acute Leukemia ◽  
Cell Cycle Progression ◽  
Expression Patterns ◽  
Cell Counting ◽  
Leukemia Cells ◽  
Luciferase Reporter ◽  
Akt Pathway ◽  
Dependent Manner ◽  
Cycle Progression

Acute leukemia is a hematological malignant tumor. Long non-coding RNA urothelial cancer-associated 1 (UCA1) is involved in the chemo-resistance of diverse cancers, but it is unclear whether UCA1 is associated with the sensitivity of acute leukemia cells to daunorubicin (DNR). DNR (100 nM) was selected for functional analysis. The viability, cell cycle progression, apoptosis, and invasion of treated acute leukemia cells (HL-60 and U-937) were evaluated by cell counting kit-8 (CCK-8) assay, flow cytometry assay, or transwell assay. Protein levels were detected with western blot analysis. Expression patterns of UCA1 and miR-613 were assessed by quantitative real-time polymerase chain reaction (qRT-PCR). The relationship between UCA1 and microRNA-613 (miR-613) was verified by dual-luciferase reporter assay. We observed that UCA1 expression was elevated in HL-60 and U-937cells. DNR constrained viability, cell cycle progression, invasion, and facilitated apoptosis of HL-60 and U-937 cells in a dose-dependent manner, but these impacts mediated by DNR were reverted after UCA1 overexpression. MiR-613 was downregulated in HL-60 and U-937 cells, and UCA1 was verified as a miR-613 sponge. MiR-613 inhibitor reversed DNR treatment-mediated effects on viability, cell cycle progression, apoptosis, and invasion of HL-60 and U-937 cells, but these impacts mediated by miR-613 inhibitor were counteracted after UCA1 inhibition. The inactivation of the PI3K/AKT pathway caused by DNR treatment was reversed after miR-613 inhibitor introduction, but this influence mediated by miR-613 inhibitor was offset after UCA1 knockdown. In conclusion, UCA1 upregulation facilitated the resistance of acute leukemia cells to DNR via the PI3K/AKT pathway by sponging miR-613.

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