scholarly journals AKT and PAX3-FKHR cooperation enforces myogenic differentiation blockade in alveolar rhabdomyosarcoma cell

Cell Cycle ◽  
2012 ◽  
Vol 11 (5) ◽  
pp. 895-908 ◽  
Author(s):  
Mathivanan Jothi ◽  
Kochi Nishijo ◽  
Charles Keller ◽  
Asoke K. Mal
Keyword(s):  
Myogenic Differentiation ◽  
Alveolar Rhabdomyosarcoma ◽  
Rhabdomyosarcoma Cell

scholarly journals Melatonin decreases cell proliferation, impairs myogenic differentiation and triggers apoptotic cell death in rhabdomyosarcoma cell lines

2015 ◽  
Vol 34 (1) ◽  
pp. 279-287 ◽  
Author(s):  
SILVIA CODENOTTI ◽  
MICHELA BATTISTELLI ◽  
SABRINA BURATTINI ◽  
SARA SALUCCI ◽  
ELISABETTA FALCIERI ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Cell Death ◽  
Cell Lines ◽  
Apoptotic Cell ◽  
Myogenic Differentiation ◽  
Apoptotic Cell Death ◽  
Rhabdomyosarcoma Cell

scholarly journals DNMT3Bin vitroknocking-down is able to reverse embryonal rhabdomyosarcoma cell phenotype through inhibition of proliferation and induction of myogenic differentiation

Oncotarget ◽  
2016 ◽  
Vol 7 (48) ◽  
pp. 79342-79356 ◽  
Author(s):  
Francesca Megiorni ◽  
Simona Camero ◽  
Simona Ceccarelli ◽  
Heather P. McDowell ◽  
Olga Mannarino ◽  
...  
Keyword(s):  
Myogenic Differentiation ◽  
Embryonal Rhabdomyosarcoma ◽  
Cell Phenotype ◽  
Inhibition Of Proliferation ◽  
Rhabdomyosarcoma Cell

Induction of myogenic differentiation in a human rhabdomyosarcoma cell line by phenylacetate

1994 ◽  
Vol 78 (1-3) ◽  
pp. 41-48 ◽  
Author(s):  
Jindrich Cinatl ◽  
Jaroslav Cinatl ◽  
Pablo Herneiz ◽  
Holger Rabenau ◽  
Milos Novak ◽  
...  
Keyword(s):  
Cell Line ◽  
Myogenic Differentiation ◽  
Rhabdomyosarcoma Cell Line ◽  
Rhabdomyosarcoma Cell

scholarly journals Reduced B7-H3 expression by PAX3-FOXO1 knockdown inhibits cellular motility and promotes myogenic differentiation in alveolar rhabdomyosarcoma

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Takuyo Kanayama ◽  
Mitsuru Miyachi ◽  
Yohei Sugimoto ◽  
Shigeki Yagyu ◽  
Ken Kikuchi ◽  
...  
Keyword(s):  
Cell Migration ◽  
Cell Lines ◽  
Gene Expression Analysis ◽  
Myogenic Differentiation ◽  
Alveolar Rhabdomyosarcoma ◽  
Cellular Motility ◽  
Cellular Context ◽  
Migration Assays ◽  
Differentiation Block ◽  
The Relationship

AbstractB7-H3 (also known as CD276) is associated with aggressive characteristics in various cancers. Meanwhile, in alveolar rhabdomyosarcoma (ARMS), PAX3-FOXO1 fusion protein is associated with increased aggressiveness and poor prognosis. In the present study, we explored the relationship between PAX3-FOXO1 and B7-H3 and the biological roles of B7-H3 in ARMS. Quantitative real time PCR and flow cytometry revealed that PAX3-FOXO1 knockdown downregulated B7-H3 expression in all the selected cell lines (Rh-30, Rh-41, and Rh-28), suggesting that PAX3-FOXO1 positively regulates B7-H3 expression. Gene expression analysis revealed that various genes and pathways involved in chemotaxis, INF-γ production, and myogenic differentiation were commonly affected by the knockdown of PAX3-FOXO1 and B7-H3. Wound healing and transwell migration assays revealed that both PAX3-FOXO1 and B7-H3 were associated with cell migration. Furthermore, knockdown of PAX3-FOXO1 or B7-H3 induced myogenin expression in all cell lines, although myosin heavy chain induction varied depending on the cellular context. Our results indicate that PAX3-FOXO1 regulates B7-H3 expression and that PAX3-FOXO1 and B7-H3 are commonly associated with multiple pathways related to an aggressive phenotype in ARMS, such as cell migration and myogenic differentiation block.

scholarly journals CircVAMP3: A circRNA with a Role in Alveolar Rhabdomyosarcoma Cell Cycle Progression

Genes ◽  
2021 ◽  
Vol 12 (7) ◽  
pp. 985
Author(s):  
Francesca Rossi ◽  
Alvaro Centrón-Broco ◽  
Dario Dattilo ◽  
Gaia Di Timoteo ◽  
Marco Guarnacci ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Progression ◽  
Circular Rna ◽  
Alveolar Rhabdomyosarcoma ◽  
Rna Modification ◽  
Circular Rnas ◽  
Cycle Progression ◽  
Non Coding Rna ◽  
Representative Cell ◽  
Rhabdomyosarcoma Cell

Circular RNAs (circRNAs), a class of covalently closed RNAs formed by a back-splicing reaction, have been involved in the regulation of diverse oncogenic processes. In this article we describe circVAMP3, a novel circular RNA overexpressed in RH4, a representative cell line of alveolar rhabdomyosarcoma. We demonstrated that circVAMP3 has a differential m6A pattern opposed to its linear counterpart, suggesting that the two isoforms can be differently regulated by such RNA modification. Moreover, we show how circVAMP3 depletion in alveolar rhabdomyosarcoma cells can impair cell cycle progression, through the alteration of the AKT-related pathways, pointing to this non-coding RNA as a novel regulator of the alveolar rhabdomyosarcoma progression and as a putative future therapeutic target.

“Verteporfin exhibits anti-proliferative activity in embryonal and alveolar rhabdomyosarcoma cell lines”

2019 ◽  
Vol 312 ◽  
pp. 108813 ◽  
Author(s):  
Luca Sanna ◽  
Roberta Piredda ◽  
Irene Marchesi ◽  
Valentina Bordoni ◽  
Sonia Vanina Forcales ◽  
...  
Keyword(s):  
Cell Lines ◽  
Proliferative Activity ◽  
Alveolar Rhabdomyosarcoma ◽  
Rhabdomyosarcoma Cell

scholarly journals Modulation of Myogenic Differentiation in a Human Rhabdomyosarcoma Cell Line by a New Derivative of 5-Fluorouracil (QF-3602)

2000 ◽  
Vol 91 (9) ◽  
pp. 934-940 ◽  
Author(s):  
Juan Antonio Marchal ◽  
Consolación Melguizo ◽  
Jose Prados ◽  
Amelia Eva Aránega ◽  
Jose Antonio Gómez ◽  
...  
Keyword(s):  
Cell Line ◽  
Myogenic Differentiation ◽  
Rhabdomyosarcoma Cell Line ◽  
Rhabdomyosarcoma Cell
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