scholarly journals Over-expression of angiotensin II type 2 receptor gene induces cell death in lung adenocarcinoma cells

2010 ◽  
Vol 9 (4) ◽  
pp. 277-285 ◽  
Author(s):  
Lara Pickel ◽  
Takaya Matsuzuka ◽  
Chiyo Doi ◽  
Rie Ayuzawa ◽  
Dharmendra Kumar Maurya ◽  
...  
Keyword(s):  
Cell Death ◽  
Angiotensin Ii ◽  
Lung Adenocarcinoma ◽  
Receptor Gene ◽  
Over Expression ◽  
Adenocarcinoma Cells ◽  
Lung Adenocarcinoma Cells

Knockdown of integrin β4-induced autophagic cell death associated with P53 in A549 lung adenocarcinoma cells

FEBS Journal ◽  
2008 ◽  
Vol 275 (22) ◽  
pp. 5725-5732 ◽  
Author(s):  
Qiuxia He ◽  
Bin Huang ◽  
Jing Zhao ◽  
Yun Zhang ◽  
Shangli Zhang ◽  
...  
Keyword(s):  
Cell Death ◽  
Lung Adenocarcinoma ◽  
Autophagic Cell Death ◽  
Adenocarcinoma Cells ◽  
Integrin Β4 ◽  
Lung Adenocarcinoma Cells ◽  
A549 Lung

scholarly journals The curcuminoid CLEFMA selectively induces cell death in H441 lung adenocarcinoma cells via oxidative stress

2010 ◽  
Vol 30 (2) ◽  
pp. 558-567 ◽  
Author(s):  
Kaustuv Sahoo ◽  
Mikhail G. Dozmorov ◽  
Shrikant Anant ◽  
Vibhudutta Awasthi
Keyword(s):  
Oxidative Stress ◽  
Cell Death ◽  
Lung Adenocarcinoma ◽  
Adenocarcinoma Cells ◽  
Lung Adenocarcinoma Cells

scholarly journals Damage-Associated Molecular Patterns (DAMPs) related to Immunogenic Cell Death are differentially triggered by clinically relevant chemotherapeutics in lung adenocarcinoma cells

2019 ◽  
Author(s):  
Eduardo Filippi-Chiela ◽  
José Ignácio Solari ◽  
Cristiano Andrade ◽  
Fabio Klamt
Keyword(s):  
Cell Death ◽  
Lung Adenocarcinoma ◽  
High Mobility ◽  
Cell Number ◽  
Immunogenic Cell Death ◽  
Strong Negative Correlation ◽  
Adenocarcinoma Cells ◽  
Lung Adenocarcinoma Cells ◽  
Molecular Patterns ◽  
Damage Associated Molecular Patterns

Abstract Background Chemotherapeutics can stimulate immune antitumor response by inducing immunogenic cell death (ICD), which is characterized by the appearance of Damage-Associated Molecular Patterns (DAMPs) like the exposure of calreticulin (CRT) in cell surface, the release of ATP and the secretion of High Mobility Group Box 1 (HMGB1). Methods Here, our objective was to investigate levels of ICD-associated DAMPs induced by chemotherapeutics commonly used in the clinical practice of non-small cell lung cancer (NSCLC) and the prognosis values of these DAMPs.A549 human lung adenocarcinoma cells were treated with cisplatin, carboplatin, etoposide, paclitaxel and gemcitabine using clinically relevant conditions (doses, times and co-treatments). We assessed ICD-associated DAMPs, cell viability, apoptosis and autophagy in an integrated way. Results We found that cisplatin induced the highest levels of apoptosis, while carboplatin and etoposide were the less cytotoxic. Cisplatin also induced the highest levels of ICD-associated DAMPs, which was not incremented by co-treatments. Etoposide induced the lower levels of ICD and the highest levels of autophagy, suggesting that the cytoprotective role of autophagy is dominant in relation to its pro-ICD role. High levels of CRT were associated with better prognosis in TCGA databank. In an integrative analysis we found a strong negative correlation between cell number and ICD-associated DAMPs as well as between autophagy and ICD-associated DAMPs. We also purpose a mathematical integration of ICD-associated DAMPs in an index (InDAMPs) that may represent with greater biological relevance this process. Conclusions Cisplatin alone induced the highest levels of ICD-associated DAMPs, so that its combination with immunotherapies can be a promising therapeutic strategy in NSCLC.

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