scholarly journals Anti-tumor activity mediated by protein and peptide transduction of HIV viral protein R (Vpr)

2009 ◽  
Vol 8 (2) ◽  
pp. 180-187 ◽  
Author(s):  
Karuppiah Muthumani ◽  
Vance M. Lambert ◽  
Mayilvahanan Shanmugam ◽  
Khanh P. Thieu ◽  
Andrew Y. Choo ◽  
...  
Keyword(s):  
Viral Protein ◽  
Viral Protein R ◽  
Peptide Transduction ◽  
Anti Tumor Activity

scholarly journals Modulation of NKG2D-Mediated Cytotoxic Functions of Natural Killer Cells by Viral Protein R from HIV-1 Primary Isolates

2012 ◽  
Vol 86 (3) ◽  
pp. 1902-1902
Author(s):  
T. N. Q. Pham ◽  
J. Richard ◽  
F. C. A. Gerard ◽  
C. Power ◽  
E. A. Cohen
Keyword(s):  
Natural Killer Cells ◽  
Natural Killer ◽  
Viral Protein ◽  
Killer Cells ◽  
Viral Protein R ◽  
Hiv 1

scholarly journals HIV-1 Integrase-Targeted Short Peptides Derived from a Viral Protein R Sequence

Molecules ◽  
2018 ◽  
Vol 23 (8) ◽  
pp. 1858 ◽  
Author(s):  
Xue Zhao ◽  
Mathieu Métifiot ◽  
Evgeny Kiselev ◽  
Jacques Kessl ◽  
Kasthuraiah Maddali ◽  
...  
Keyword(s):  
Viral Protein ◽  
Divalent Metal ◽  
Common Mechanism ◽  
Strand Transfer ◽  
Divalent Metal Ions ◽  
Dna Interactions ◽  
Inhibitory Potency ◽  
New Class ◽  
Viral Protein R ◽  
Hiv 1

HIV-1 integrase (IN) inhibitors represent a new class of highly effective anti-AIDS therapeutics. Current FDA-approved IN strand transfer inhibitors (INSTIs) share a common mechanism of action that involves chelation of catalytic divalent metal ions. However, the emergence of IN mutants having reduced sensitivity to these inhibitors underlies efforts to derive agents that antagonize IN function by alternate mechanisms. Integrase along with the 96-residue multifunctional accessory protein, viral protein R (Vpr), are both components of the HIV-1 pre-integration complex (PIC). Coordinated interactions within the PIC are important for viral replication. Herein, we report a 7-mer peptide based on the shortened Vpr (69–75) sequence containing a biotin group and a photo-reactive benzoylphenylalanyl residue, and which exhibits low micromolar IN inhibitory potency. Photo-crosslinking experiments have indicated that the peptide directly binds IN. The peptide does not interfere with IN-DNA interactions or induce higher-order, aberrant IN multimerization, suggesting a mode of action for the peptide that is distinct from clinically used INSTIs and developmental allosteric IN inhibitors. This compact Vpr-derived peptide may serve as a valuable pharmacological tool to identify a potential new pharmacologic site.

scholarly journals Peptides derived from the C-terminal domain of HIV-1 Viral Protein R in lipid bilayers: Structure, membrane positioning and gene delivery

2020 ◽  
Vol 1862 (2) ◽  
pp. 183149
Author(s):  
Arnaud Marquette ◽  
Christian Leborgne ◽  
Vanessa Schartner ◽  
Evgeniy Salnikov ◽  
Burkhard Bechinger ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Lipid Bilayers ◽  
Viral Protein ◽  
Terminal Domain ◽  
Viral Protein R ◽  
Hiv 1

Bis-iridoid and iridoid glycosides: Viral protein R inhibitors from Picrorhiza kurroa collected in Myanmar

Fitoterapia ◽  
2019 ◽  
Vol 134 ◽  
pp. 101-107 ◽  
Author(s):  
Nwet Nwet Win ◽  
Takeshi Kodama ◽  
Khine Zar Wynn Lae ◽  
Yi Yi Win ◽  
Hla Ngwe ◽  
...  
Keyword(s):  
Viral Protein ◽  
Iridoid Glycosides ◽  
Picrorhiza Kurroa ◽  
Viral Protein R

scholarly journals The effect of childhood trauma, ApoE genotype and HIV-1 viral protein R variants on change in cognitive performance

2019 ◽  
Vol 12 (1) ◽  
Author(s):  
Jacqueline S. Womersley ◽  
Lara B. Clauss ◽  
Olivette Varathan ◽  
Susan Engelbrecht ◽  
Sian M. J. Hemmings ◽  
...  
Keyword(s):  
Cognitive Performance ◽  
Childhood Trauma ◽  
Viral Protein ◽  
Apoe Genotype ◽  
Risk Scores ◽  
Viral Protein R ◽  
Gene Environment ◽  
Calculated Risk ◽  
Neuropsychological Assessments

Abstract Objective Gene–environment interactions contribute to the development of HIV-associated neurocognitive disorders. We examined whether childhood trauma, apolipoprotein E isoforms and viral protein R (Vpr) variants were associated with change in cognitive performance. Seventy-three seropositive women completed neuropsychological assessments at baseline and 1-year follow-up. We conducted genetic analyses using DNA obtained from blood and calculated risk scores based on Vpr amino acid 37, 41 and 55 variants that were previously associated with cognitive performance. Results Global cognitive scores declined significantly over the 1-year study period (p = 0.029). A reduction in global cognitive scores was associated with childhood trauma experience (p = 0.039).

Anti-cancer activity of the HIV accessory molecule viral protein R (Vpr): Delivery as a DNA expression plasmid or biologically active peptides

Vaccine ◽  
2010 ◽  
Vol 28 (8) ◽  
pp. 2005-2010 ◽  
Author(s):  
Karrupiah Muthumani ◽  
Vance M. Lambert ◽  
Omkar Kawalekar ◽  
Richard Heller ◽  
J. Joseph Kim ◽  
...  
Keyword(s):  
Viral Protein ◽  
Biologically Active ◽  
Expression Plasmid ◽  
Active Peptides ◽  
Viral Protein R ◽  
Anti Cancer ◽  
Biologically Active Peptides ◽  
Accessory Molecule ◽  
Cancer Activity
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