scholarly journals Recent Advances in Cell Biology, Diagnosis and Therapy of Gastrointestinal Stroma Tumor (GIST)

2004 ◽  
Vol 3 (3) ◽  
pp. 251-258 ◽  
Author(s):  
Roberto Logrono ◽  
Dennie V. Jones ◽  
Sohaib Faruqi ◽  
Manoop S. Bhutani
Keyword(s):  
Cell Biology ◽  
Diagnosis And Therapy ◽  
Recent Advances ◽  
Gastrointestinal Stroma Tumor

Recent Advances of Small Molecular Regulators Targeting G Protein- Coupled Receptors Family for Oncology Immunotherapy

2019 ◽  
Vol 19 (16) ◽  
pp. 1464-1483 ◽  
Author(s):  
Peng He ◽  
Wenbo Zhou ◽  
Mingyao Liu ◽  
Yihua Chen
Keyword(s):  
G Protein ◽  
Cell Biology ◽  
Immune Cell ◽  
G Protein Coupled Receptors ◽  
Treatment Modalities ◽  
Immune Checkpoints ◽  
Considerable Proportion ◽  
Prostaglandin E ◽  
Recent Advances ◽  
G Protein Coupled

The great clinical success of chimeric antigen receptor T cell (CAR-T) and PD-1/PDL-1 inhibitor therapies suggests the drawing of a cancer immunotherapy age. However, a considerable proportion of cancer patients currently receive little benefit from these treatment modalities, indicating that multiple immunosuppressive mechanisms exist in the tumor microenvironment. In this review, we mainly discuss recent advances in small molecular regulators targeting G Protein-Coupled Receptors (GPCRs) that are associated with oncology immunomodulation, including chemokine receptors, purinergic receptors, prostaglandin E receptor EP4 and opioid receptors. Moreover, we outline how they affect tumor immunity and neoplasia by regulating immune cell recruitment and modulating tumor stromal cell biology. We also summarize the data from recent clinical advances in small molecular regulators targeting these GPCRs, in combination with immune checkpoints blockers, such as PD-1/PDL-1 and CTLA4 inhibitors, for cancer treatments.

scholarly journals Evolution of Bioengineered Lung Models: Recent Advances and Challenges in Tissue Mimicry for Studying the Role of Mechanical Forces in Cell Biology

2019 ◽  
Vol 29 (39) ◽  
pp. 1903114 ◽  
Author(s):  
Ali Doryab ◽  
Sinem Tas ◽  
Mehmet Berat Taskin ◽  
Lin Yang ◽  
Anne Hilgendorff ◽  
...  
Keyword(s):  
Cell Biology ◽  
Mechanical Forces ◽  
Recent Advances

Recent advances in the cell biology of chlorophyll catabolism

2001 ◽  
pp. 1-52 ◽  
Author(s):  
Howard Thomas ◽  
Helen Ougham ◽  
Stefan Hörtensteiner
Keyword(s):  
Cell Biology ◽  
Recent Advances

scholarly journals Erratum: Recent Advances in Dendritic Cell Biology

2005 ◽  
Vol 25 (3) ◽  
pp. 175-188 ◽  
Author(s):  
Sylvia Adams ◽  
David W. O’Neill ◽  
Nina Bhardwaj
Keyword(s):  
Dendritic Cell ◽  
Cell Biology ◽  
Recent Advances

Recent advances in hematopoietic stem cell biology

2004 ◽  
Vol 11 (6) ◽  
pp. 392-398 ◽  
Author(s):  
Jesper Bonde ◽  
David A Hess ◽  
Jan A Nolta
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Cell Biology ◽  
Stem Cell Biology ◽  
Hematopoietic Stem ◽  
Recent Advances
Sign in / Sign up

Export Citation Format

Share Document