scholarly journals Genetically engineered Newcastle disease virus expressing interleukin-2 and TNF-related apoptosis-inducing ligand for cancer therapy

2014 ◽  
Vol 15 (9) ◽  
pp. 1226-1238 ◽  
Author(s):  
Fu-Liang Bai ◽  
Yin-Hang Yu ◽  
Hui Tian ◽  
Gui-Ping Ren ◽  
Hui Wang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Newcastle Disease Virus ◽  
Disease Virus ◽  
Newcastle Disease ◽  
Interleukin 2 ◽  
Genetically Engineered

Genetically engineered oncolytic Newcastle disease virus mediates cytolysis of prostate cancer stem like cells

2017 ◽  
Vol 260 ◽  
pp. 91-97 ◽  
Author(s):  
Shobana Raghunath ◽  
Raghavendra Sumanth Pudupakam ◽  
Adria Allen ◽  
Moanaro Biswas ◽  
Nammalwar Sriranganathan
Keyword(s):  
Prostate Cancer ◽  
Newcastle Disease Virus ◽  
Disease Virus ◽  
Newcastle Disease ◽  
Genetically Engineered

scholarly journals Safety and Clinical Usage of Newcastle Disease Virus in Cancer Therapy

2011 ◽  
Vol 2011 ◽  
pp. 1-13 ◽  
Author(s):  
Han Yuen Lam ◽  
Swee Keong Yeap ◽  
Mehdi Rasoli ◽  
Abdul Rahman Omar ◽  
Khatijah Yusoff ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Newcastle Disease Virus ◽  
Disease Virus ◽  
Newcastle Disease ◽  
Human Tumor ◽  
Wild Type ◽  
Anticancer Effect ◽  
Human Tumor Cells ◽  
Immunological Effects ◽  
Oncolytic Effect

Newcastle disease virus (NDV) is an avian virus that causes deadly infection to over 250 species of birds, including domestic and wild-type, thus resulting in substantial losses to the poultry industry worldwide. Many reports have demonstrated the oncolytic effect of NDV towards human tumor cells. The interesting aspect of NDV is its ability to selectively replicate in cancer cells. Some of the studies have undergone human clinical trials, and favorable results were obtained. Therefore, NDV strains can be the potential therapeutic agent in cancer therapy. However, investigation on the therapeutic perspectives of NDV, especially human immunological effects, is still ongoing. This paper provides an overview of the current studies on the cytotoxic and anticancer effect of NDV via direct oncolysis effects or immune stimulation. Safety of NDV strains applied for cancer immunotherapy is also discussed in this paper.

scholarly journals Genetically engineered Newcastle disease virus for malignant melanoma therapy

Gene Therapy ◽  
2009 ◽  
Vol 16 (6) ◽  
pp. 796-804 ◽  
Author(s):  
D Zamarin ◽  
A Vigil ◽  
K Kelly ◽  
A García-Sastre ◽  
Y Fong
Keyword(s):  
Malignant Melanoma ◽  
Newcastle Disease Virus ◽  
Disease Virus ◽  
Newcastle Disease ◽  
Genetically Engineered ◽  
Melanoma Therapy

scholarly journals Exploring the Prospects of Engineered Newcastle Disease Virus in Modern Vaccinology

Viruses ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 451 ◽  
Author(s):  
Muhammad Bashir Bello ◽  
Khatijah Yusoff ◽  
Aini Ideris ◽  
Mohd Hair-Bejo ◽  
Abdurrahman Hassan Jibril ◽  
...  
Keyword(s):  
Molecular Biology ◽  
Infectious Diseases ◽  
Newcastle Disease Virus ◽  
Disease Virus ◽  
Newcastle Disease ◽  
Reverse Genetics ◽  
Emerging Infectious Diseases ◽  
Genetically Engineered ◽  
Antigen Delivery ◽  
Design Development

Many traditional vaccines have proven to be incapable of controlling newly emerging infectious diseases. They have also achieved limited success in the fight against a variety of human cancers. Thus, innovative vaccine strategies are highly needed to overcome the global burden of these diseases. Advances in molecular biology and reverse genetics have completely restructured the concept of vaccinology, leading to the emergence of state-of-the-art technologies for vaccine design, development and delivery. Among these modern vaccine technologies are the recombinant viral vectored vaccines, which are known for their incredible specificity in antigen delivery as well as the induction of robust immune responses in the vaccinated hosts. Although a number of viruses have been used as vaccine vectors, genetically engineered Newcastle disease virus (NDV) possesses some useful attributes that make it a preferable candidate for vectoring vaccine antigens. Here, we review the molecular biology of NDV and discuss the reverse genetics approaches used to engineer the virus into an efficient vaccine vector. We then discuss the prospects of the engineered virus as an efficient vehicle of vaccines against cancer and several infectious diseases of man and animals.

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