scholarly journals Antiproliferative effect of a novel mTOR inhibitor temsirolimus contributes to the prolonged survival of orthotopic esophageal cancer-bearing mice

2013 ◽  
Vol 14 (3) ◽  
pp. 230-236 ◽  
Author(s):  
Toshio Nishikawa ◽  
Munenori Takaoka ◽  
Toshiaki Ohara ◽  
Yasuko Tomono ◽  
Huifang Hao ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Mtor Inhibitor ◽  
Antiproliferative Effect ◽  
Prolonged Survival

The association of PET response with complete pathological response (CPR) and residual nodal disease (RND) after induction chemoradiotherapy (CRT) and resection of esophageal cancer: A review of 493 cases

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. 4552-4552
Author(s):  
S. A. Barnett ◽  
N. P. Rizk ◽  
P. S. Adusumilli ◽  
B. J. Park ◽  
M. S. Bains ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Prolonged Survival ◽  
Categorical Variables ◽  
R0 Resection ◽  
Continuous Variables ◽  
Nodal Disease ◽  
Poor Survival ◽  
Chi Square ◽  
Kaplan Meier ◽  
Adeno Carcinoma

4552 Background: RND and lack of CPR of the primary tumor correlate with poor survival after induction CRT and resection of esophageal cancer. PET response to CRT (SUVmax change and post-induction SUVmax) is used by some clinicians as an indicator of CPR and RND in order to stratify patients after CRT to observation alone vs completion resection. We aimed to investigate the association of PET response with CPR and RND after induction CRT and resection of esophageal cancer. Methods: An IRB-approved retrospective review of an institutional surgical database identified patients who underwent resection of esophageal squamous cell (SCC) and adeno carcinoma (AC) following CRT. The database was locked on Sept 30, 2008. Categorical variables were analyzed by chi square, continuous variables by t-test, and survival by the Kaplan-Meier method. Results: From 1/96 to 3/08, 493 patients were identified, 82% were male. Median age was 62, chemotherapy cisplatin-based in 87%, mean radiation 50 Gy, in-hospital mortality 4.1% and R0 resection rate 88%. Pathology revealed AC in 80%, lack of CPR in 73% and RND in 35%. While in AC patients CPR and lack of RND were both associated with prolonged survival, PET response was not associated with either. In SCC patients, prolonged survival was associated with CPR but not with lack of RND. In SCC, PET response was associated with CPR but not RND. In these patients, reduction in SUVmax <50, 50–75 and >75% was associated with CPR rates of 29, 44 and 85% respectively (p=0.02). Conclusions: These results do not support the use of PET response to justify observation alone after CRT in esophageal AC. With respect to SCC, though exploratory, these provocative results support further study of the use of PET response to predict CPR. [Table: see text] No significant financial relationships to disclose.

Chemoradiotherapy plus surgery versus surgery alone for resectable esophageal cancer: A systematic review of randomized control trials.

2012 ◽  
Vol 30 (4_suppl) ◽  
pp. 94-94
Author(s):  
Basile M. Njei ◽  
Juliet Appiah ◽  
Ivo C. Ditah ◽  
John W. Birk
Keyword(s):  
Quality Of Life ◽  
Esophageal Cancer ◽  
Adverse Events ◽  
Cell Cancer ◽  
Group Versus ◽  
Prolonged Survival ◽  
Cochrane Library ◽  
Term Survival ◽  
Surgery Group

94 Background: Several trials have demonstrated better survival when surgery is combined with neoadjuvant chemotherapy and concurrent radiotherapy (CRT) in the treatment of esophageal cancer (EC). However, it is unclear whether survival benefits are counterbalanced by a poor quality of life due to the adverse effects of the combination therapy. The aim of this study was to compare the efficacy and safety of CRT plus surgery versus surgery alone. Methods: Two authors independently conducted a comprehensive search of the Cochrane library PUBMED, MEDLINE, and published proceedings from major oncologic cancer meetings from January 1980 to July 2011. The titles and abstracts of all potentially relevant studies were screened for eligibility. In addition to overall outcome measures, subgroup analysis by histology of EC (squamous cell cancer [SCC] and adenocarcinoma [AC]), was also performed. Analysis was done using the fixed effect model. The Begg’s and Egger’s tests with visual inspection of the funnel plot were used to assess for population bias. Results: Fifteen studies involving 1,957 patients were included in the analysis. There was an overall statistically significant increase in the 5-year survival for the CRT plus surgery group versus the surgery only group (RR 1.47, 95% CI 1.24-1.76). By histological type, only patients with SCC showed prolonged survival: RR 1.53, 95% CI 1.26-1.85. We equally found an overall significant increase in grade 3 and 4 adverse events in the CRT plus surgery group compared to the group with surgery alone (RR 1.73, 95% CI 1.15-2.60). Again, a significant increase in serious adverse events was observed only in the sub-group of patients with SCC (RR 1.81, 95% CI 1.14-2.86). There was no evidence of heterogeneity or publication bias in these analyses. Conclusions: Overall, CRT plus surgery can improve long-term survival in EC patients. The results seem to be limited only to patients with SCC and not AC. However, the prolonged survival comes at the cost of poorer quality of life due to a higher incidence of adverse events. For the moment we recommend that the decision on what treatment strategy to use be based on informed patient preference.

scholarly journals Antiproliferative effect of the HSP90 inhibitor NVP-AUY922 is determined by the expression of PTEN in esophageal cancer

2012 ◽  
Vol 29 (1) ◽  
pp. 45-50 ◽  
Author(s):  
XIAO-HONG BAO ◽  
MUNENORI TAKAOKA ◽  
HUI-FANG HAO ◽  
TAKUYA FUKAZAWA ◽  
TOMOKI YAMATSUJI ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Hsp90 Inhibitor ◽  
Antiproliferative Effect

scholarly journals Palliative resection or radiation of primary tumor prolonged survival for metastatic esophageal cancer

2019 ◽  
Vol 8 (17) ◽  
pp. 7253-7264 ◽  
Author(s):  
Jing Xu ◽  
Donghui Lu ◽  
Li Zhang ◽  
Jian Li ◽  
Guoping Sun
Keyword(s):  
Esophageal Cancer ◽  
Primary Tumor ◽  
Palliative Resection ◽  
Prolonged Survival

Individualized, multimodal palliative treatment of inoperable esophageal cancer: Clinical impact of photodynamic therapy resulting in prolonged survival

2012 ◽  
Vol 44 (3) ◽  
pp. 189-198 ◽  
Author(s):  
Joerg Lindenmann ◽  
Veronika Matzi ◽  
Nicole Neuboeck ◽  
Udo Anegg ◽  
Eva Baumgartner ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Photodynamic Therapy ◽  
Palliative Treatment ◽  
Clinical Impact ◽  
Prolonged Survival
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