scholarly journals Trans-resveratrol boronic acid exhibits enhanced anti-proliferative activity on estrogen-dependent MCF-7 breast cancer cells

2012 ◽  
Vol 13 (10) ◽  
pp. 925-934 ◽  
Author(s):  
Venkata Mahidhar Yenugonda ◽  
Yali Kong ◽  
Tushar B. Deb ◽  
Yonghong Yang ◽  
Rebecca B. Riggins ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Boronic Acid ◽  
Proliferative Activity ◽  
Breast Cancer Cells ◽  
Mcf 7

Decrease in Cell Viability of Breast Cancer Cells by a Di-Hydroxylated Derivative of N-(2-hydroxyphenyl)-2-Propylpentanamide

2021 ◽  
Vol 21 ◽  
Author(s):  
Norma Lizeth Galindo-Alvarez ◽  
Humberto L. Mendoza-Figueroa ◽  
Martha Cecilia Rosales-Hernández ◽  
Norbert Bakalara ◽  
José Correa-Basurto
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Cell Lines ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Proliferative Activity ◽  
Breast Cancer Cells ◽  
Breast Cancer Cell Lines ◽  
Hydroxyl Groups ◽  
Mcf 7

Background: A preliminary study of the biotransformation by cytochrome P450 enzymes (CYP) of N-(2-hydroxyphenyl)-2-propylpentanamide (HO-AAVPA), an HDAC inhibitor, led to the synthesis of two hydroxylated derivatives: N-(2,4-dihydroxyphenyl)-2-propylpentanamide (5a) and N-(2,5-dihydroxyphenyl)-2-propylpentanamide (5b). Objective: The study aims to evaluate the anti-proliferative activity of these di-hydroxylated derivatives in breast cancer cell lines. Methods: MTT assays were conducted in MCF-7 and MDA-MB-231 cell lines. Additionally, in silico studies were carried out to evaluate the affinity of these derivatives with the HDAC1 enzyme. Results: Results showed that only 5b possess an enhanced anti-proliferative effect in breast cancer cell lines MCF-7 and MDA-MB-231. Docking studies revealed that the presence of hydroxyl groups, as well as the position of the additional hydroxyl groups, could have an impact on HDAC1 affinity and could explain the lack of activity of compound 5a. Conclusion: A priori, these results hypothesize that anti-proliferative activity of 5b could be related to HDAC1 inhibition and thus anti-proliferative activity in breast cancer cells.

scholarly journals Improvement of the anti-proliferative activity of the peptide ERα17p in MCF-7 breast cancer cells using nanodiamonds

2019 ◽  
Vol 77 (6) ◽  
pp. 488-495 ◽  
Author(s):  
François Yip ◽  
Fariba Nemati ◽  
Rania El Botty ◽  
Mathilde Belnou ◽  
Didier Decaudin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Proliferative Activity ◽  
Breast Cancer Cells ◽  
Mcf 7

Anti-proliferative activities of flavone–estradiol Stille-coupling adducts and of indanone-based compounds obtained by SnCl4/Zn-catalysed McMurry cross-coupling reactions

RSC Advances ◽  
2015 ◽  
Vol 5 (101) ◽  
pp. 83512-83521 ◽  
Author(s):  
Gulab Khushalrao Pathe ◽  
Naveen K. Konduru ◽  
Iram Parveen ◽  
Naseem Ahmed
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Proliferative Activity ◽  
Breast Cancer Cells ◽  
Cross Coupling ◽  
Coupling Reactions ◽  
Stille Coupling ◽  
Cross Coupling Reactions ◽  
Mcmurry Reaction ◽  
Mcf 7

Flavone–estradiol adducts and indanophen based tamoxifen analogs are synthesized using SnCl4–Zn reagent via McMurry reaction and evaluated in human cervical (HeLa) and breast cancer cells (MCF-7 and MDA-MB-231) for the anti-proliferative activity.

Sign in / Sign up

Export Citation Format

Share Document