scholarly journals Loss of stromal caveolin-1 expression predicts poor clinical outcome in triple negative and basal-like breast cancers

2010 ◽  
Vol 10 (2) ◽  
pp. 135-143 ◽  
Author(s):  
Agnieszka K. Witkiewicz ◽  
Abhijit Dasgupta ◽  
Sara Sammons ◽  
Ozlem Er ◽  
Magdalena Potoczek ◽  
...  
Keyword(s):  
Clinical Outcome ◽  
Triple Negative ◽  
Breast Cancers ◽  
Poor Clinical Outcome ◽  
Caveolin 1

scholarly journals An Absence of Stromal Caveolin-1 Expression Predicts Early Tumor Recurrence and Poor Clinical Outcome in Human Breast Cancers

2009 ◽  
Vol 174 (6) ◽  
pp. 2023-2034 ◽  
Author(s):  
Agnieszka K. Witkiewicz ◽  
Abhijit Dasgupta ◽  
Federica Sotgia ◽  
Isabelle Mercier ◽  
Richard G. Pestell ◽  
...  
Keyword(s):  
Clinical Outcome ◽  
Tumor Recurrence ◽  
Breast Cancers ◽  
Human Breast ◽  
Poor Clinical Outcome ◽  
Caveolin 1 ◽  
Early Tumor ◽  
Early Tumor Recurrence

Caveolin-1 expression as a prognostic marker in triple negative breast cancers of Asian women

2017 ◽  
Vol 71 (2) ◽  
pp. 161-167 ◽  
Author(s):  
Joe Yeong ◽  
Aye Aye Thike ◽  
Murasaki Ikeda ◽  
Jeffrey Chun Tatt Lim ◽  
Bernett Lee ◽  
...  
Keyword(s):  
Overall Survival ◽  
Stromal Cells ◽  
Triple Negative ◽  
Tumour Cells ◽  
Clinicopathological Parameters ◽  
Asian Women ◽  
Cancer Type ◽  
Breast Cancers ◽  
Caveolin 1 ◽  
Disease Outcomes

BackgroundTriple-negative breast cancers (TNBCs) are defined by their lack of oestrogen receptor, progesterone receptor and epidermal growth factor receptor 2. Although heterogeneous, the majority are aggressive and treatment options are limited. Caveolin acts as tumour suppressor or promoter depending on the cancer type.AimIn this study, we aimed to determine if the expression levels of the candidate biomarker caveolin-1 on stromal or tumour cells were associated with clinicopathological parameters and disease outcomes in TNBCs from an ethnically diverse cohort of Asian women.MethodsTumour specimens from 699 women with TNBC were subjected to immunohistochemical analysis of the frequency and intensity of caveolin-1 expression in tumour and stromal cells. A subset of 141 tumour samples also underwent Nanostring measurement of CAV1 mRNA. Results were correlated with clinicopathological parameters and disease outcomes.ResultsExpression of caveolin-1 in stromal cells was observed in 14.4% of TNBC cases. TNBCs of the basal-like phenotype (85% of samples) were significantly more likely to exhibit stromal cell caveolin-1 expression (p=0.028), as were those with a trabecular growth pattern (p=0.007). Lack of stromal caveolin-1 expression in both TNBCs and those with the basal-like phenotype was significantly associated with worse overall survival (p=0.009 and p=0.026, respectively): accordingly, increasing mRNA levels of CAV1 in TNBC samples predicted better overall survival. Caveolin-1 expression on TNBC tumour cells was not associated with clinical outcome.ConclusionStromal, but not tumoural, caveolin-1 expression is significantly associated with survival in Asian women with TNBC.

High Chemokine Receptor CXCR4 Level in Triple Negative Breast Cancer Specimens Predicts Poor Clinical Outcome

2010 ◽  
Vol 159 (2) ◽  
pp. 689-695 ◽  
Author(s):  
Quyen D. Chu ◽  
Lori Panu ◽  
Neal T. Holm ◽  
Benjamin D.L. Li ◽  
Lester W. Johnson ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Clinical Outcome ◽  
Triple Negative Breast Cancer ◽  
Chemokine Receptor ◽  
Triple Negative ◽  
Poor Clinical Outcome ◽  
Chemokine Receptor Cxcr4

scholarly journals Co-dependency for MET and FGFR1 in basal triple-negative breast cancers

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Vanessa Y. C. Sung ◽  
Jennifer F. Knight ◽  
Radia M. Johnson ◽  
Yaakov E. Stern ◽  
Sadiq M. Saleh ◽  
...  
Keyword(s):  
Receptor Tyrosine Kinase ◽  
Triple Negative ◽  
Tumour Progression ◽  
Patient Stratification ◽  
Breast Cancers ◽  
Poor Clinical Outcome ◽  
Relapse Free Survival ◽  
Free Survival ◽  
Dual Inhibition

AbstractTriple-negative breast cancer (TNBC) is a heterogeneous disease that lacks both effective patient stratification strategies and therapeutic targets. Whilst elevated levels of the MET receptor tyrosine kinase are associated with TNBCs and predict poor clinical outcome, the functional role of MET in TNBC is still poorly understood. In this study, we utilise an established Met-dependent transgenic mouse model of TNBC, human cell lines and patient-derived xenografts to investigate the role of MET in TNBC tumorigenesis. We find that in TNBCs with mesenchymal signatures, MET participates in a compensatory interplay with FGFR1 to regulate tumour-initiating cells (TICs). We demonstrate a requirement for the scaffold protein FRS2 downstream from both Met and FGFR1 and find that dual inhibition of MET and FGFR1 signalling results in TIC depletion, hindering tumour progression. Importantly, basal breast cancers that display elevated MET and FGFR1 signatures are associated with poor relapse-free survival. Our results support a role for MET and FGFR1 as potential co-targets for anti-TIC therapies in TNBC.

Phosphorylated c-Src predicts clinical outcome in triple negative breast cancers.

2009 ◽  
Author(s):  
B Elsberger ◽  
SM Tovey ◽  
BA Tan ◽  
SB Brown ◽  
VG Brunton ◽  
...  
Keyword(s):  
Clinical Outcome ◽  
Triple Negative ◽  
Breast Cancers
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