scholarly journals Elevated Cell Invasion Is Induced by Hypoxia in a Human Pituitary Adenoma Cell Line

2007 ◽  
Vol 1 (1) ◽  
pp. 43-51 ◽  
Author(s):  
Daizo Yoshida ◽  
Akira Teramoto
Keyword(s):  
Pituitary Adenoma ◽  
Cell Line ◽  
Cell Invasion ◽  
Human Pituitary ◽  
Human Pituitary Adenoma ◽  
Adenoma Cell

A human pituitary adenoma cell line proliferates and maintains some differentiated functions following expression of SV40 large T-antigen

1998 ◽  
Vol 9 (2) ◽  
pp. 169-184 ◽  
Author(s):  
Long Jin ◽  
Elzbieta Kulig ◽  
Xiang Qian ◽  
Bernd W. Scheithauer ◽  
Norman L. Eberhardt ◽  
...  
Keyword(s):  
Pituitary Adenoma ◽  
Cell Line ◽  
T Antigen ◽  
Large T Antigen ◽  
Sv40 Large T Antigen ◽  
Human Pituitary ◽  
Human Pituitary Adenoma ◽  
Adenoma Cell

Specific Somatostatin Receptors on Human Pituitary Adenoma Cell Membranes*

1985 ◽  
Vol 61 (4) ◽  
pp. 666-671 ◽  
Author(s):  
SHOICHIRO IKUYAMA ◽  
HAJIME NAWATA ◽  
KEN'ICHI KATO ◽  
TSUYOSHI KARASHIMA ◽  
HIROSHI IBAYASHI ◽  
...  
Keyword(s):  
Pituitary Adenoma ◽  
Cell Membranes ◽  
Somatostatin Receptors ◽  
Human Pituitary ◽  
Human Pituitary Adenoma ◽  
Adenoma Cell

Induction of GH, PRL, and TSHβ mRNA by transfection of Pit-1 in a human pituitary adenoma-derived cell line

2005 ◽  
Vol 322 (2) ◽  
pp. 269-277 ◽  
Author(s):  
Shunsuke Miyai ◽  
Shinichi Yoshimura ◽  
Yasumasa Iwasaki ◽  
Susumu Takekoshi ◽  
Ricardo V. Lloyd ◽  
...  
Keyword(s):  
Pituitary Adenoma ◽  
Cell Line ◽  
Human Pituitary ◽  
Human Pituitary Adenoma

scholarly journals Curcumin suppresses HIF1A synthesis and VEGFA release in pituitary adenomas

2012 ◽  
Vol 214 (3) ◽  
pp. 389-398 ◽  
Author(s):  
B Shan ◽  
C Schaaf ◽  
A Schmidt ◽  
K Lucia ◽  
M Buchfelder ◽  
...  
Keyword(s):  
Pituitary Adenoma ◽  
Cell Cultures ◽  
Curcuma Longa ◽  
Pituitary Tumour ◽  
Tumour Cells ◽  
Gh3 Cells ◽  
Mrna Synthesis ◽  
Human Pituitary ◽  
Human Pituitary Adenoma ◽  
Adenoma Cell

Curcumin (diferuloylmethane), a polyphenolic compound derived from the spice plantCurcuma longa, displays multiple actions on solid tumours including anti-angiogenic effects. Here we have studied in rodent and human pituitary tumour cells the influence of curcumin on the production of hypoxia inducible factor 1α (HIF1A) and vascular endothelial growth factor A (VEGFA), two key components involved in tumour neovascularisation through angiogenesis. Curcumin dose-dependently inhibited basal VEGFA secretion in corticotroph AtT20 mouse and lactosomatotroph GH3 rat pituitary tumour cells as well as in all human pituitary adenoma cell cultures (n=32) studied. Under hypoxia-mimicking conditions (CoCl2treatment) in AtT20 and GH3 cells as well as in all human pituitary adenoma cell cultures (n=8) studied, curcumin strongly suppressed the induction of mRNA synthesis and protein production of HIF1A, the regulated subunit of the hypoxia-induced transcription factor HIF1. Curcumin also blocked hypoxia-induced mRNA synthesis and secretion of VEGFA in GH3 cells and in all human pituitary adenoma cell cultures investigated (n=18). Thus, curcumin may inhibit pituitary adenoma progression not only through previously demonstrated anti-proliferative and pro-apoptotic actions but also by its suppressive effects on pituitary tumour neovascularisation.

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