Activation of the PI3K-Akt-mTOR signaling pathway promotes necrotic cell death via suppression of autophagy

You-Tong Wu; Hui-Ling Tan; Qing Huang; Choon-Nam Ong; Han-Ming Shen

doi:10.4161/auto.9099

Activation of the PI3K-Akt-mTOR signaling pathway promotes necrotic cell death via suppression of autophagy

Autophagy ◽

10.4161/auto.9099 ◽

2009 ◽

Vol 5 (6) ◽

pp. 824-834 ◽

Cited By ~ 134

Author(s):

You-Tong Wu ◽

Hui-Ling Tan ◽

Qing Huang ◽

Choon-Nam Ong ◽

Han-Ming Shen

Keyword(s):

Cell Death ◽

Signaling Pathway ◽

Mtor Signaling ◽

Necrotic Cell Death ◽

Mtor Signaling Pathway ◽

Necrotic Cell

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Abstract A18: Geranylgeranoic acid (GGA) induced autophagic cell death through induction of unfolded protein response (UPR) and suppression of mTOR signaling pathway

10.1158/1538-8514.pi3k14-a18 ◽

2015 ◽

Author(s):

Chieko Iwao ◽

Yoshihiro Shidoji

Keyword(s):

Cell Death ◽

Unfolded Protein Response ◽

Signaling Pathway ◽

Mtor Signaling ◽

Autophagic Cell Death ◽

Mtor Signaling Pathway ◽

Unfolded Protein ◽

Protein Response

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PAMAM Nanoparticles Promote Acute Lung Injury by Inducing Autophagic Cell Death through the Akt-TSC2-mTOR Signaling Pathway

Journal of Molecular Cell Biology ◽

10.1093/jmcb/mjp002 ◽

2009 ◽

Vol 1 (1) ◽

pp. 37-45 ◽

Cited By ~ 185

Author(s):

C. Li ◽

H. Liu ◽

Y. Sun ◽

H. Wang ◽

F. Guo ◽

...

Keyword(s):

Cell Death ◽

Acute Lung Injury ◽

Lung Injury ◽

Signaling Pathway ◽

Mtor Signaling ◽

Autophagic Cell Death ◽

Mtor Signaling Pathway

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Cytoprotective effect of kaempferol against palmitic acid-induced pancreatic β-cell death through modulation of autophagy via AMPK/mTOR signaling pathway

Molecular and Cellular Endocrinology ◽

10.1016/j.mce.2017.02.033 ◽

2017 ◽

Vol 448 ◽

pp. 1-20 ◽

Cited By ~ 36

Author(s):

Ritu Varshney ◽

Sumeet Gupta ◽

Partha Roy

Keyword(s):

Cell Death ◽

Palmitic Acid ◽

Signaling Pathway ◽

Mtor Signaling ◽

Pancreatic Β Cell ◽

Mtor Signaling Pathway ◽

Cytoprotective Effect ◽

Β Cell

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PAMAM Nanoparticles Promote Acute Lung Injury by Inducing Autophagic Cell Death through the Akt-TSC2-mTOR Signaling Pathway

Journal of Molecular Cell Biology ◽

10.1093/jmcb/mjq003 ◽

2010 ◽

Vol 2 (2) ◽

pp. 103-103 ◽

Cited By ~ 8

Author(s):

C. Li ◽

H. Liu ◽

Y. Sun ◽

H. Wang ◽

F. Guo ◽

...

Keyword(s):

Cell Death ◽

Acute Lung Injury ◽

Lung Injury ◽

Signaling Pathway ◽

Mtor Signaling ◽

Autophagic Cell Death ◽

Mtor Signaling Pathway

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Low Frequency Magnetic Fields Induce Autophagy-associated Cell Death in Lung Cancer through miR-486-mediated Inhibition of Akt/mTOR Signaling Pathway

Scientific Reports ◽

10.1038/s41598-017-10407-w ◽

2017 ◽

Vol 7 (1) ◽

Cited By ~ 7

Author(s):

Yujun Xu ◽

Yizhong Wang ◽

Anran Yao ◽

Zhen Xu ◽

Huan Dou ◽

...

Keyword(s):

Lung Cancer ◽

Cell Death ◽

Magnetic Fields ◽

Signaling Pathway ◽

Low Frequency ◽

Mtor Signaling ◽

Mtor Signaling Pathway

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Retraction: PM02734 (Elisidepsin) Induces Caspase-Independent Cell Death Associated with Features of Autophagy, Inhibition of the Akt/mTOR Signaling Pathway, and Activation of Death-Associated Protein Kinase

Clinical Cancer Research ◽

10.1158/1078-0432.ccr-13-1910 ◽

2013 ◽

Vol 19 (17) ◽

pp. 4900-4900

Keyword(s):

Cell Death ◽

Protein Kinase ◽

Signaling Pathway ◽

Mtor Signaling ◽

Mtor Signaling Pathway ◽

Death Associated Protein Kinase ◽

Autophagy Inhibition

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Suppression of PI3K-Akt-mTOR Signaling Pathway in Paradoxical EGF-Induced Cell Death

Annals of Oncology ◽

10.1093/annonc/mdt459.129 ◽

2013 ◽

Vol 24 ◽

pp. ix59

Author(s):

W. Hong-Gyun ◽

K. Kim ◽

S.-R. Jeon

Keyword(s):

Cell Death ◽

Signaling Pathway ◽

Mtor Signaling ◽

Mtor Signaling Pathway

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Coptisine induces autophagic cell death through down-regulation of PI3K/Akt/mTOR signaling pathway and up-regulation of ROS-mediated mitochondrial dysfunction in hepatocellular carcinoma Hep3B cells

Archives of Biochemistry and Biophysics ◽

10.1016/j.abb.2020.108688 ◽

2021 ◽

Vol 697 ◽

pp. 108688

Author(s):

So Young Kim ◽

Hyun Hwangbo ◽

Min Yeong Kim ◽

Seon Yeong Ji ◽

Hyesook Lee ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Cell Death ◽

Mitochondrial Dysfunction ◽

Signaling Pathway ◽

Mtor Signaling ◽

Autophagic Cell Death ◽

Mtor Signaling Pathway ◽

Down Regulation ◽

Hep3b Cells

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Water-soluble germanium nanoparticles cause necrotic cell death and the damage can be attenuated by blocking the transduction of necrotic signaling pathway

Toxicology Letters ◽

10.1016/j.toxlet.2011.09.018 ◽

2011 ◽

Vol 207 (3) ◽

pp. 258-269 ◽

Cited By ~ 22

Author(s):

Yu-Hsin Ma ◽

Chin-Ping Huang ◽

Jia-Shiuan Tsai ◽

Mo-Yuan Shen ◽

Yaw-Kuen Li ◽

...

Keyword(s):

Cell Death ◽

Signaling Pathway ◽

Water Soluble ◽

Necrotic Cell Death ◽

Necrotic Cell ◽

Germanium Nanoparticles

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Ginsenoside Rk1 induces cell death through ROS-mediated PTEN/PI3K/Akt/mTOR signaling pathway in MCF-7 cells

Journal of Functional Foods ◽

10.1016/j.jff.2019.04.019 ◽

2019 ◽

Vol 57 ◽

pp. 255-265 ◽

Cited By ~ 4

Author(s):

Yinan Hong ◽

Daidi Fan

Keyword(s):

Cell Death ◽

Signaling Pathway ◽

Mtor Signaling ◽

Mtor Signaling Pathway ◽

Mcf 7

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