scholarly journals The role of the P2X7 receptor signaling pathway for the release of autolysosomes in microglial cells

Autophagy ◽  
2009 ◽  
Vol 5 (5) ◽  
pp. 723-724 ◽  
Author(s):  
Takato Takenouchi ◽  
Masayo Fujita ◽  
Shuei Sugama ◽  
Hiroshi Kitani ◽  
Makoto Hashimoto
Keyword(s):  
Signaling Pathway ◽  
P2x7 Receptor ◽  
Microglial Cells ◽  
Receptor Signaling ◽  
Receptor Signaling Pathway

Mechanism of growth inhibition by MicroRNA 145: The role of the IGF-I receptor signaling pathway

2009 ◽  
Vol 220 (2) ◽  
pp. 485-491 ◽  
Author(s):  
Gaspare La Rocca ◽  
Margherita Badin ◽  
Bin Shi ◽  
Shi-Qiong Xu ◽  
Tiziana DeAngelis ◽  
...  
Keyword(s):  
Growth Inhibition ◽  
Signaling Pathway ◽  
Receptor Signaling ◽  
Igf I ◽  
Receptor Signaling Pathway ◽  
Mechanism Of Growth

scholarly journals Long Noncoding RNA Expression Profile in BV2 Microglial Cells Exposed to Lipopolysaccharide

2019 ◽  
Vol 2019 ◽  
pp. 1-9
Author(s):  
Yajuan Li ◽  
Qingmin Li ◽  
Cunjuan Wang ◽  
Shengde Li ◽  
Lingzhi Yu
Keyword(s):  
Neuropathic Pain ◽  
Signaling Pathway ◽  
Noncoding Rna ◽  
Cell Activation ◽  
Differentially Expressed ◽  
Microglial Cells ◽  
Receptor Signaling ◽  
Microglia Cell ◽  
Receptor Signaling Pathway

Neuropathic pain, which is one of the most common forms of chronic pain, seriously increases healthcare costs and impairs patients’ quality of life with an incidence of 7–10% worldwide. Microglia cell activation plays a key role in the progression of neuropathic pain. Better understanding of novel molecules modulating microglia cell activation and these underlying functions will extremely benefit the exploration of new treatment. Recent studies suggested long noncoding RNAs may be involved in neuropathic pain. However, its underlying functions and mechanisms in microglia cell activation remain unclear. To identify the differentially expressed lncRNAs and predict their functions in the progression of microglia cell activation, GSE103156 was analyzed using integrated bioinformatics methods. The expression levels of selected lncRNAs and mRNAs were determined by real-time PCR. In the present study, a total of 56 lncRNAs and 298 mRNAs were significantly differentially expressed. The differentially expressed mRNAs were mainly enriched in NF-kappa B signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, and NOD-like receptor signaling pathway. The top 10 hub genes were Tnf, Il6, Stat1, Cxcl10, Il1b, Tlr2, Irf1, Ccl2, Irf7, and Ccl5 in the PPI network. Our results showed that Gm8989, Gm8979, and AV051173 may be involved in the progression of microglia cell activation. Taken together, our findings suggest that lots of lncRNAs may be involved in BV2 microglia cell activation in vitro. The findings may provide relevant information for the development of promising targets for the microglial cells activation of neuropathic pain in vivo in the future.

Potential Role of the Toll-Like Receptor Signaling Pathway in Equine Laminitis

2010 ◽  
Vol 30 (2) ◽  
pp. 113-114 ◽  
Author(s):  
A.M. Stokes ◽  
M.L. Keowen ◽  
M. McGeachy ◽  
K. Carlisle ◽  
F. Garza
Keyword(s):  
Signaling Pathway ◽  
Potential Role ◽  
Receptor Signaling ◽  
Toll Like Receptor ◽  
Receptor Signaling Pathway
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